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NR5A2

Official Full Name

NR5A2 nuclear receptor subfamily 5, group A, member 2
Overview

Liver receptor homolog-1 (LRH-1), also known as NR5A2, is a member of the orphan nuclear receptor family. It has been linked to a variety of processes, such as bile acid metabolism, reverse cholesterol transport, cell proliferation in the developing pancreas, and steroidogenesis.
Synonyms

NR5A2; nuclear receptor subfamily 5, group A, member 2; FTF; nuclear receptor subfamily 5 group A member 2; B1F2; FTZ F1; FTZ F1beta; hB1F; hB1F 2; liver receptor homolog 1; LRH 1; nuclear receptor NR5A2; liver receptor homolog-1; CYP7A promoter-binding factor; hepatocytic transcription factor; alpha-1-fetoprotein transcription factor; liver nuclear receptor homolog-1 variant 2; fetoprotein-alpha 1 (AFP) transcription factor; b1-binding factor, hepatocyte transcription factor which activates enhancer II of hepatitis B virus; B1F; CPF; LRH1; LRH-1; FTZ-F1; hB1F-2; FTZ-F1beta;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rat
Zebrafish

Source

E.coli
HEK293
In Vitro Cell Free System
Insect Cell
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
Myc
His|T7
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	NR5A2-1052H	Recombinant Human NR5A2	Insect Cell	N/A		Inquiry
Human	NR5A2-1092H	Recombinant Human NR5A2 protein, His-tagged	E.coli	His	Ser300~Ala541	Inquiry
Human	NR5A2-1053H	Recombinant Human NR5A2, GST-tagged	E.coli	GST		Inquiry
Human	NR5A2-6747HF	Recombinant Full Length Human NR5A2 Protein, GST-tagged	In Vitro Cell Free System	GST	495 amino acids	Inquiry
Human	NR5A2-6100H	Recombinant Human NR5A2 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Mouse	Nr5a2-3292M	Recombinant Mouse Nr5a2 protein, His&Myc-tagged	E.coli	His&Myc	1-560aa	Inquiry
Rat	Nr5a2-1093R	Recombinant Rat Nr5a2 protein, His & T7-tagged	E.coli	His/T7	Met1~Ala205 (Accession # Q9QWM1)	Inquiry
Rat	NR5A2-4074R	Recombinant Rat NR5A2 Protein	Mammalian Cell	His		Inquiry
Rat	NR5A2-3733R	Recombinant Rat NR5A2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	NR5A2-3733R-B	Recombinant Rat NR5A2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	NR5A2-9030Z	Recombinant Zebrafish NR5A2	Mammalian Cell	His		Inquiry
Chicken	NR5A2-6635C	Recombinant Chicken NR5A2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

NR5A2 involved in several pathways and played different roles in them. We selected most pathways NR5A2 participated on our site, such as Maturity onset diabetes of the young, which may be useful for your reference. Also, other proteins which involved in the same pathway with NR5A2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Maturity onset diabetes of the young	NEUROG3;INS;FOXA2;HNF4A;HNF4G;INS2;SLC2A2;PAX4;NKX6

NR5A2 has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II distal enhancer sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NR5A2 itself. We selected most functions NR5A2 had, and list some proteins which have the same functions with NR5A2. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	POU3F2A;POLR3K;ZNF143;DNASE1L3;ZNF484;HER6;H2AFB2;ZNF404;UBN2
RNA polymerase II core promoter proximal region sequence-specific DNA binding	DPF2;BCL11B;NKX6-1;ZNF92;JDP2;KCNIP3;POU4F2;ZSCAN21;SREBF1
RNA polymerase II distal enhancer sequence-specific DNA binding	ESRRB;MEOX2;NR5A2;SIX3;HNRNPC;MED12;ZBTB16;NFKB1;CDX2
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding	NR2F1A;RORCB;AHR2;NR2F6B;ESRRA;NR4A2B;RORC;HNF4G;PPARD
chromatin binding	TPR;TOP1;BAHD1;GATA3;AIRE;PATZ1;PRMT6;CALCOCO1;SIRT7
phospholipid binding	HIP1RB;BIN2;APOA1;NBEA;NR5A2;PSD2;APOB;ANXA9;SPTBN2
protein binding	NEK3;ARL2;KIF4A;MXD1;RPL15;TTC37;FAP;KRTAP10-5;AMMECR1
sequence-specific DNA binding	FOXC2;HOXD3A;LHX1B;MSXE;IRX6;RX2;CREBZF;HOXD10A;HOXB10A
steroid hormone receptor activity	RORAB;PPARAB;RXRBB;OR51E2;VDRA;NR3C2;NR5A1B;ESRRGA;RXRB
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	RFX1;RFX3;SNAI2;FOXF2A;SRY;NR5A1;HNF4A;MYF6;GATA6
transcription factor activity, sequence-specific DNA binding	TRPS1;NFAT5;PBX1B;RHOXF1;HMG20A;KLF17;HIVEP2;DMBX1;NR2C2
transcription regulatory region DNA binding	KLF15;SMAD3;IKZF4;GATA5;CTCF;GABPB1;ZBTB14;SP1;HNF1A
transcription regulatory region sequence-specific DNA binding	CRY2;MEF2CA;ZNF658;NONO;NFE2L2B;HIF1AL;GATA1;PSPC1;PITX2
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	TXK;SOX4;MYB;GATA3;GATA1;FOXJ1;PATZ1;ESR1;TCF21
zinc ion binding	RBM10;PCGF5B;ADAM25;NR2F6;USP45;RNF44;MORC3B;BMI1B;ADAMTS4

NR5A2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NR5A2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NR5A2.

UBE2I; EDF1; PROX1