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NUP214

  • Official Full Name

    nucleoporin 214kDa

  • Overview

    The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene is a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is localized to the cytoplasmic face of the nuclear pore complex where it is required for proper cell cycle progression and nucleocytoplasmic transport. The 3 portion of this gene forms a fusion gene with the DEK gene on chromosome 6 in a t(6,9) translocation associated with acute myeloid leukemia and myelodysplastic syndrome.
  • Synonyms

    NUP214; nucleoporin 214kDa; nucleoporin 214kD (CAIN); nuclear pore complex protein Nup214; CAIN; CAN; CAN protein; putative oncogene; D9S46E; N214; 214 kDa nucleoporin; NU214_HUMAN; Nucleoporin Nup214; Protein CAN; p250; CAN protein, putative oncogene;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Mouse NUP214-10994M Recombinant Mouse NUP214 Protein Mammalian Cell His
Mouse Nup214-1563M Recombinant Mouse Nup214 protein, His & T7-tagged E.coli His/T7 Ser601~Arg868 (Accession # Q80U93)
Mouse NUP214-6271M Recombinant Mouse NUP214 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse NUP214-6271M-B Recombinant Mouse NUP214 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • NUP214 Related Articles

NUP214 involved in several pathways and played different roles in them. We selected most pathways NUP214 participated on our site, such as RNA transport, Epstein-Barr virus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with NUP214 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
RNA transportRPP14;UPF3B;NUP133;EIF3G;NCBP1;DDX20;EIF3S10;EIF4A3;SENP2
Epstein-Barr virus infectionVIM;HLA-DRB4;CD38;PLCG2;PSMD7;NFKB2;HDAC2;TNFAIP3;SHFM1

NUP214 has several biochemical functions, for example, nuclear localization sequence binding, nucleocytoplasmic transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NUP214 itself. We selected most functions NUP214 had, and list some proteins which have the same functions with NUP214. You can find most of the proteins on our site.

Function Related Protein
nuclear localization sequence bindingKPNB3;KPNA4;KPNB1;RANBP6;IPO4;TNPO3;KPNA7;KPNA2;BRAP
nucleocytoplasmic transporter activityNUP54;NUP133;NUP35;NUP153;XPO1;RBM22;UPF3A;NUP214;NUPL1

NUP214 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NUP214 here. Most of them are supplied by our site. Hope this information will be useful for your research of NUP214.

RAE1; NUP188; NUP93; NUP88; OGT; NUP214; NUP98; pp7052; NUP155; KRT75; HEXB; NUP62; RANGAP1; NUP153; RANBP2; STAT2

Copeland, AM; Newcomb, WW; et al. Herpes Simplex Virus Replication: Roles of Viral Proteins and Nucleoporins in Capsid-Nucleus Attachment. JOURNAL OF VIROLOGY 83:1660-1668(2009).
Paulillo, SM; Powers, MA; et al. Changes in nucleoporin domain topology in response to chemical effectors. JOURNAL OF MOLECULAR BIOLOGY 363:39-50(2006).
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