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Official Full Name purinergic receptor P2X, ligand-gated ion channel, 1
Background The protein encoded by this gene belongs to the P2X family of G-protein-coupled receptors. These proteins can form homo-and heterotimers and function as ATP-gated ion channels and mediate rapid and selective permeability to cations. This protein is primarily localized to smooth muscle where binds ATP and mediates synaptic transmission between neurons and from neurons to smooth muscle and may being responsible for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. This protein may also be involved in promoting apoptosis. [provided by RefSeq, Jun 2013]
Synonyms P2RX1; purinergic receptor P2X, ligand-gated ion channel, 1; P2X1; P2X purinoceptor 1; ATP receptor; P2X1 receptor; P2X receptor, subunit 1; purinergic receptor P2X1;
    • Species :
    • Chicken
    • Human
    • Zebrafish
    • Source :
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human P2RX1-464HCL Recombinant Human P2RX1 lysate HEK293 N/A
    Chicken P2RX1-6088C Recombinant Chicken P2RX1 Mammalian Cell His
    Zebrafish P2RX1-9886Z Recombinant Zebrafish P2RX1 Mammalian Cell His

    p2rx1 involved in several pathways and played different roles in them. We selected most pathways p2rx1 participated on our site, such as Calcium signaling pathway, Neuroactive ligand-receptor interaction, Platelet activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with p2rx1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Calcium signaling pathway PLCD1B; P2RX3B; ADRB1; ADRB2; CHRM2; ADORA2A; GNA14; GRM1; ADRB3B; GNA15.4
    Neuroactive ligand-receptor interaction KISS1RB; SSTR4; GHRA; TRHRB; GALR3; S1PR3; GHR; CHRNA2; ADRA2DA; NPFFR2.1
    Platelet activation FGB; VASP; PIK3R5; PTGIR; PIK3CA; GNAI3; LCP2; ITGB3; PLA2G4D; PIK3R2

    p2rx1 has several biochemical functions, for example, ATP binding, calcium channel activity, cation channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by p2rx1 itself. We selected most functions p2rx1 had, and list some proteins which have the same functions with p2rx1. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding RAD51C; MLH3; DGKE; SEPHS1; ATP1A3; NME2A; MAP4K2; AFG3L2; NLRP5; HIPK3B
    calcium channel activity TRPC7A; CACNA1C; PKD1; AKR1C1; TRPV1; TRPC4A; GPM6A; UBXN6; CACNG7A; CACNA1BA
    cation channel activity ASIC4B; MCOLN1; GAR1; GRIN2C; TRPC1; PKD1; P2RX1; FAM38B; CALHM3; ASIC1C
    drug binding DCK; FOLR1; HMGB2; TLR8; HTR2C; HTR1B; SLC6A4A; CHRNA3; FNTB; CNR1
    extracellular ATP-gated cation channel activity P2RX3A; P2RX3B; P2RX4; P2RX7; P2RX8; P2RX6; P2RX4B; P2RX2; NNR; P2RX4A
    purinergic nucleotide receptor activity P2RX1; P2RX3B; P2RX2; P2RX5; P2RX4; P2RX3A; P2RX4B; P2RX4A; NNR; P2RX7
    zinc ion binding CA5; PARK2; MARCH10; ZDHHC18B; ZNF622; RBM20; ZYX; NANOS3; TRIM101; SH3RF1

    p2rx1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with p2rx1 here. Most of them are supplied by our site. Hope this information will be useful for your research of p2rx1.

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