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P2RX1

Official Full Name

purinergic receptor P2X, ligand-gated ion channel, 1
Overview

The protein encoded by this gene belongs to the P2X family of G-protein-coupled receptors. These proteins can form homo-and heterotimers and function as ATP-gated ion channels and mediate rapid and selective permeability to cations. This protein is primarily localized to smooth muscle where binds ATP and mediates synaptic transmission between neurons and from neurons to smooth muscle and may being responsible for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. This protein may also be involved in promoting apoptosis. [provided by RefSeq, Jun 2013]
Synonyms

P2RX1; purinergic receptor P2X, ligand-gated ion channel, 1; P2X1; P2X purinoceptor 1; ATP receptor; P2X1 receptor; P2X receptor, subunit 1; purinergic receptor P2X1;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	P2RX1-464HCL	Recombinant Human P2RX1 lysate	HEK293	N/A		Inquiry
Human	P2RX1-3648H	Recombinant Human P2RX1 protein, His-tagged	E.coli	His	196-291 aa	$319 / 25ug
Mouse	P2rx1-1888M	Recombinant Mouse P2rx1 Protein, His-tagged	E.coli	N-His	Thr57-Gly338	Inquiry
Zebrafish	P2RX1-9886Z	Recombinant Zebrafish P2RX1	Mammalian Cell	His		Inquiry
Chicken	P2RX1-6088C	Recombinant Chicken P2RX1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

P2RX1 involved in several pathways and played different roles in them. We selected most pathways P2RX1 participated on our site, such as Calcium signaling pathway, Neuroactive ligand-receptor interaction, Platelet activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with P2RX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Calcium signaling pathway	CAMK4;ADRB3B;CHRM5B;GNAL;CALM3B;CALM2;AKR1C1;PPP3R1;CYSLTR1
Neuroactive ligand-receptor interaction	PTH2R;GABRA2;GLRBB;CHRNA10;TAAR7B;CNR2;S1PR2;CHRNB3B;MAS1
Platelet activation	PIK3CG;TLN1;PLCG2;MAPK1;MYLK2;GNAI2;PLA2G4D;PIK3CD;LCP2

P2RX1 has several biochemical functions, for example, ATP binding, calcium channel activity, cation channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by P2RX1 itself. We selected most functions P2RX1 had, and list some proteins which have the same functions with P2RX1. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	ATP9B;SPATA5L1;MST1R;OXSR1B;PDGFRB;NAT10;ULK3;BMPR2;POMK
calcium channel activity	RYR1B;SLC24A4A;TRPV3;TRPV4;PDE2A;TRPM6;PANX1;ITPR3;TRPM2
cation channel activity	P2RX1;MCOLN1;TRPM1B;GRIN3B;ASIC4A;GRIN2C;TRPV4;ASIC4B;FAM26D
drug binding	CYP4B1;TOP2A;SFRP1;NR1I2;RARB;HTR2A;PIGC;SRP54A;SLC6A4A
extracellular ATP-gated cation channel activity	P2RX4A;P2RX4;P2RX4B;P2RX7;P2RX2;P2RX3B;P2RX3;P2RX6;P2RX3A
purinergic nucleotide receptor activity	P2RX6;P2RX2;P2RX3A;P2RX5;P2RX4B;P2RX4A;P2RX3B;P2RX8;P2RX3
zinc ion binding	KCMF1;LHX9;ADAT3;WBP7;CAPNS2;SF1;MYNN;TRAF3;PRICKLE1A

P2RX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with P2RX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of P2RX1.