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P4HA2

Official Full Name

prolyl 4-hydroxylase, alpha polypeptide II
Background

This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described.
Synonyms

P4HA2; prolyl 4-hydroxylase, alpha polypeptide II; procollagen proline, 2 oxoglutarate 4 dioxygenase (proline 4 hydroxylase), alpha polypeptide II; prolyl 4-hydroxylase subunit alpha-2; 4 PH alpha 2; C P4Halpha(II); collagen prolyl 4 hydroxylase alpha(II); 2-oxoglutarate-4-dioxygenase subunit alpha-2; 4-PH alpha-2; P4HA2_HUMAN; Procollagen-proline; Prolyl 4 hydroxylase alpha 2 subunit; Prolyl 4 hydroxylase subunit alpha 2 [Precursor]; 4-PH alpha 2; C-P4Halpha(II); collagen prolyl 4-hydroxylase alpha(II); procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-2; procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide II;

Type:
Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species :
Chicken
Human
Mouse
Rhesus Macaque
Zebrafish

Source :
E.coli
HEK293
HEK293T
Mammalian Cell

Tag :
His
His (Fc)
Avi
His|T7
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Price
Chicken	P4HA2-1307C	Recombinant Chicken P4HA2	Mammalian Cell	His	Inquiry
Human	P4HA2-3481HCL	Recombinant Human P4HA2 293 Cell Lysate	HEK293	N/A	Inquiry
Human	P4HA2-1178H	Recombinant Human P4HA2 protein, His & T7-tagged	E.coli	His/T7	Inquiry
Human	P4HA2-1578H	Recombinant Human P4HA2 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK	Inquiry
Mouse	P4ha2-4641M	Recombinant Mouse P4ha2 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK	Inquiry
Rhesus Macaque	P4HA2-3274R	Recombinant Rhesus monkey P4HA2 Protein, His-tagged	Mammalian Cell	His	Inquiry
Rhesus Macaque	P4HA2-3092R	Recombinant Rhesus Macaque P4HA2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	$2,998.00 / 50ug
Rhesus Macaque	P4HA2-3092R-B	Recombinant Rhesus Macaque P4HA2 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Zebrafish	P4HA2-1680Z	Recombinant Zebrafish P4HA2	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein
P4HA2 Related Research Area

P4HA2 involved in several pathways and played different roles in them. We selected most pathways P4HA2 participated on our site, such as Arginine and proline metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with P4HA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Arginine and proline metabolism	LSM1;CKMT2B;CNDP1;CKMA;NOS3;PRODH2;P4HA1;PYCR2;ADC
Metabolic pathways	NDUFAB1A;INPP5E;DLAT;PTGDSB;ALDOB;NAGK;PIGH;ATP5J;ITGB1BP3

P4HA2 has several biochemical functions, for example, L-ascorbic acid binding, electron carrier activity, iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by P4HA2 itself. We selected most functions P4HA2 had, and list some proteins which have the same functions with P4HA2. You can find most of the proteins on our site.

Function	Related Protein
L-ascorbic acid binding	PAM;P4HA3;DBH;EGLN1B;PLOD2;PLOD3;LEPRE1;TMLHE;OGFOD3
electron carrier activity	GCDHB;P4HA2;AKR1A1;GCDH;NDUFS6;AOX3L1;GSR;IDO1;CYCSB
iron ion binding	CYP3A25;JHDM1D;HBAD;CYP2B19;Agmo;CYP2C37;CYP2D6;HBQ1;PLOD1A
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	BCO2;ADOB;P4HA1B;P4HA1;P4HA2;TMLHE;P4HA3;ALOX12B;ALOX5B.3
procollagen-proline 4-dioxygenase activity	P4HA1B;P4HA3;P4HA1;P4HA1A;P4HA2
protein binding	PRAP1;HIST1H3F;GLS2;FOS;MOBKL2B;Itga10&Itgb1;CD276;RBM26;ITGB1BP2

P4HA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with P4HA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of P4HA2.

DMWD; CREB3; PRRC2A; IRS4; cona_canen; env; H2AFX; EBNA-LP

ECM Regulators