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P4HA2

Official Full Name

prolyl 4-hydroxylase, alpha polypeptide II
Overview

This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described.
Synonyms

P4HA2; prolyl 4-hydroxylase, alpha polypeptide II; procollagen proline, 2 oxoglutarate 4 dioxygenase (proline 4 hydroxylase), alpha polypeptide II; prolyl 4-hydroxylase subunit alpha-2; 4 PH alpha 2; C P4Halpha(II); collagen prolyl 4 hydroxylase alpha(II); 2-oxoglutarate-4-dioxygenase subunit alpha-2; 4-PH alpha-2; P4HA2_HUMAN; Procollagen-proline; Prolyl 4 hydroxylase alpha 2 subunit; Prolyl 4 hydroxylase subunit alpha 2 [Precursor]; 4-PH alpha 2; C-P4Halpha(II); collagen prolyl 4-hydroxylase alpha(II); procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-2; procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide II;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rhesus Macaque
Zebrafish

Source

E.coli
HEK293
HEK293T
Mammalian Cell

Tag

His
His (Fc)
Avi
His|T7
Myc
DDK
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	P4HA2-1178H	Recombinant Human P4HA2 protein, His & T7-tagged	E.coli	His/T7	Ser207~Glu520 (Accession # O15460)	Inquiry
Human	P4HA2-3481HCL	Recombinant Human P4HA2 293 Cell Lysate	HEK293	N/A		Inquiry
Human	P4HA2-1578H	Recombinant Human P4HA2 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	P4HA2-5266H	Recombinant Human P4HA2 Protein (Ser207-Glu520), N-His tagged	E.coli	N-His	Ser207-Glu520	Inquiry
Mouse	P4ha2-4641M	Recombinant Mouse P4ha2 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Rhesus Macaque	P4HA2-3274R	Recombinant Rhesus monkey P4HA2 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	P4HA2-3092R	Recombinant Rhesus Macaque P4HA2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	P4HA2-3092R-B	Recombinant Rhesus Macaque P4HA2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	P4HA2-1680Z	Recombinant Zebrafish P4HA2	Mammalian Cell	His		Inquiry
Chicken	P4HA2-1307C	Recombinant Chicken P4HA2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

P4HA2 involved in several pathways and played different roles in them. We selected most pathways P4HA2 participated on our site, such as Arginine and proline metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with P4HA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Arginine and proline metabolism	DAO;SAT1A.2;SAT2;ALDH2.2;CARNS1;ODC1;CKMT2;DHDPSL;NOS2A
Metabolic pathways	DPM3;NME1-NME2;AHCY;HPSE2;GLS;XYLT2;AMPD1;FTCD;CYP4F2

P4HA2 has several biochemical functions, for example, L-ascorbic acid binding, electron carrier activity, iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by P4HA2 itself. We selected most functions P4HA2 had, and list some proteins which have the same functions with P4HA2. You can find most of the proteins on our site.

Function	Related Protein
L-ascorbic acid binding	P4HA1;EGLN1;DBH;LEPRE1;PHYH;ALKBH3;PLOD1;PLOD3;OGFOD2
electron carrier activity	GRX2;AKR1B1;CIAPIN1;AKR1C4;ACADS;TSTA3;SDHB;GLRX;PHGDH
iron ion binding	CYP19A1B;ALOX15;CYP4T8;CYP2A6;TYW5;CYP3A4;FAM125B;CYP1B1;CYP4F22
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	P4HA3;P4HA1;ADOB;ALOX5B.2;ALOX8;ADOA;ALOX5B.3;ALOX12B;P4HA1B
procollagen-proline 4-dioxygenase activity	P4HA2;P4HA1B;P4HA1;P4HA1A;P4HA3
protein binding	SMYD2;TIMP1;CIRBP;H2AFY;TMCO6;CCKBR;TNFRSF12A;RAB4A;FCN1

P4HA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with P4HA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of P4HA2.

DMWD; CREB3; PRRC2A; IRS4; cona_canen; env; H2AFX; EBNA-LP