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  • Official Full Name

    prolyl 4-hydroxylase, alpha polypeptide III

  • Overview

    This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined.
  • Synonyms

    P4HA3; prolyl 4-hydroxylase, alpha polypeptide III; procollagen proline, 2 oxoglutarate 4 dioxygenase (proline 4 hydroxylase), alpha polypeptide III; prolyl 4-hydroxylase subunit alpha-3; C P4Halpha(III); collagen prolyl 4 hydroxylase alpha(III); 4-PH alpha-3; Procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide III; Procollagen-proline, 2-oxoglutarate 4-dioxygenase, alpha subunit, isoform 3; Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-3; Prolyl 4-hydroxylase, alpha-3 subunit; C-P4H alpha III; collagen prolyl 4-hydroxylase alpha(III);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Rat
  • E.coli
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • His|T7
  • SUMO
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human P4HA3-320H Recombinant Human P4HA3 Protein, His-tagged E.coli His
Human P4HA3-1179H Recombinant Human P4HA3 protein, His & T7-tagged E.coli His/T7 Glu227~Asp544 (Accession # Q7Z4N8)
Human P4HA3-3480HCL Recombinant Human P4HA3 293 Cell Lysate HEK293 N/A
Human P4HA3-4591H Recombinant Human P4HA3 protein, His-SUMO-tagged E.coli His-SUMO 20-544aa
Rat P4HA3-4241R Recombinant Rat P4HA3 Protein Mammalian Cell His
Rat P4HA3-3903R Recombinant Rat P4HA3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat P4HA3-3903R-B Recombinant Rat P4HA3 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • P4HA3 Related Articles

P4HA3 involved in several pathways and played different roles in them. We selected most pathways P4HA3 participated on our site, such as Arginine and proline metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with P4HA3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Arginine and proline metabolismPYCR1A;ABP1;GATM;AZIN2;NOS3;PRODH;DAO.1;L3HYPDH;PYCR2

P4HA3 has several biochemical functions, for example, L-ascorbic acid binding, iron ion binding, oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen. Some of the functions are cooperated with other proteins, some of the functions could acted by P4HA3 itself. We selected most functions P4HA3 had, and list some proteins which have the same functions with P4HA3. You can find most of the proteins on our site.

Function Related Protein
L-ascorbic acid bindingOGFOD1;PLOD1;LEPREL2;PAM;P4HA2;P4HA1;PLOD3;FAM125B;LEPREL1
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygenP4HA1B;ADOB;TMLHE;BCO2;ALOX5A;P4HA1A;ALOX12B;P4HA1;ALOX12E
procollagen-proline 4-dioxygenase activityP4HA1;P4HA2;P4HA1A;P4HA1B;P4HA3
protein bindingSALL1;DNA2;C20orf195;HMOX1;RARG;EDN1;CDT1;EDA;FAM153C

P4HA3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with P4HA3 here. Most of them are supplied by our site. Hope this information will be useful for your research of P4HA3.


Li, L; Zhang, K; et al. Adiponectin Upregulates Prolyl-4-Hydroxylase alpha 1 Expression in Interleukin 6-Stimulated Human Aortic Smooth Muscle Cells by Regulating ERK 1/2 and Sp1. PLOS ONE 6:-(2011).
Pakkanen, O; Pirskanen, A; et al. Selective expression of nonsecreted triple-helical and secreted single-chain recombinant collagen fragments in the yeast Pichia pastoris. JOURNAL OF BIOTECHNOLOGY 123:248-256(2006).
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