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P4HA3

Official Full Name

prolyl 4-hydroxylase, alpha polypeptide III
Overview

This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined.
Synonyms

P4HA3; prolyl 4-hydroxylase, alpha polypeptide III; procollagen proline, 2 oxoglutarate 4 dioxygenase (proline 4 hydroxylase), alpha polypeptide III; prolyl 4-hydroxylase subunit alpha-3; C P4Halpha(III); collagen prolyl 4 hydroxylase alpha(III); 4-PH alpha-3; Procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide III; Procollagen-proline, 2-oxoglutarate 4-dioxygenase, alpha subunit, isoform 3; Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-3; Prolyl 4-hydroxylase, alpha-3 subunit; C-P4H alpha III; collagen prolyl 4-hydroxylase alpha(III);

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Rat

Source

E.coli
HEK293
Mammalian Cell

Tag

His
Fc
Avi
SUMO
T7
Non

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	P4HA3-320H	Recombinant Human P4HA3 Protein, His-tagged	E.coli	His		Inquiry
Human	P4HA3-1179H	Recombinant Human P4HA3 protein, His & T7-tagged	E.coli	His&T7	Glu227~Asp544 (Accession # Q7Z4N8)	Inquiry
Human	P4HA3-3480HCL	Recombinant Human P4HA3 293 Cell Lysate	HEK293	Non		Inquiry
Human	P4HA3-4591H	Recombinant Human P4HA3 protein, His-SUMO-tagged	E.coli	His&SUMO	20-544aa	Inquiry
Rat	P4HA3-4241R	Recombinant Rat P4HA3 Protein	Mammalian Cell	His		Inquiry
Rat	P4HA3-3903R	Recombinant Rat P4HA3 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Rat	P4HA3-3903R-B	Recombinant Rat P4HA3 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

P4HA3 involved in several pathways and played different roles in them. We selected most pathways P4HA3 participated on our site, such as Arginine and proline metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with P4HA3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Arginine and proline metabolism	PRODH;AGMAT;P4HA1;DAO1;SAT2B;SAT2;P4HA1B;MAOB;ABP1
Metabolic pathways	CKMT1A;POLR2A;UGT1A1;AGPS;PON2;HAO1;DAO;NNMT;LDHBB

P4HA3 has several biochemical functions, for example, L-ascorbic acid binding, iron ion binding, oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen. Some of the functions are cooperated with other proteins, some of the functions could acted by P4HA3 itself. We selected most functions P4HA3 had, and list some proteins which have the same functions with P4HA3. You can find most of the proteins on our site.

Function	Related Protein
L-ascorbic acid binding	P4HTM;OGFOD2;LEPRE1;LEPREL1;PLOD2;EGLN2;EGLN1B;P4HA1A;OGFOD3
iron ion binding	LTF;CYP3C1;PLOD3;XDH;CYP19A1A;CYP2AA2;PAH;PDF;CYP4V7
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	BCO2;ADOA;P4HA1B;TMLHE;P4HA3;P4HA1;ALOX12E;ALOX5B.2;ALOX12
procollagen-proline 4-dioxygenase activity	P4HA1A;P4HA1B;P4HA1;P4HA3;P4HA2
protein binding	LDHD;TBCEL;CD300A;MATN1;CYBRD1;FOXP4;C7orf50;ATXN7;STK38

P4HA3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with P4HA3 here. Most of them are supplied by our site. Hope this information will be useful for your research of P4HA3.

MEOX2; HGS; WDR62; SERTAD1; ZC3H12A; NUTM1; MAGEA2B

Research Area

Li, L; Zhang, K; et al. Adiponectin Upregulates Prolyl-4-Hydroxylase alpha 1 Expression in Interleukin 6-Stimulated Human Aortic Smooth Muscle Cells by Regulating ERK 1/2 and Sp1. PLOS ONE 6:-(2011).

Pakkanen, O; Pirskanen, A; et al. Selective expression of nonsecreted triple-helical and secreted single-chain recombinant collagen fragments in the yeast Pichia pastoris. JOURNAL OF BIOTECHNOLOGY 123:248-256(2006).