PAF1
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Official Full Name
Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)
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Overview
This gene encodes a subunit of the polymerase associated factor (PAF1) complex. The PAF1 complex interacts with RNA polymerase II and plays a role in transcription elongation as well as histone modifications including ubiquitylation and methylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012] -
Synonyms
PAF1; Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae); PD2; F23149_1; RNA polymerase II-associated factor 1 homolog; pancreatic differentiation protein 2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- Mammalian Cell
- GST
- His
- His (Fc)
- Avi
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- PAF1 Related Research Area
PAF1 involved in several pathways and played different roles in them. We selected most pathways PAF1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PAF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
PAF1 has several biochemical functions, for example, RNA polymerase II core binding, chromatin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PAF1 itself. We selected most functions PAF1 had, and list some proteins which have the same functions with PAF1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II core binding | ZNF326;CDC73;AGO2;CTR9;SMYD2;AGO1;RPRD1B;GTF2E1;SMYD2A |
| chromatin binding | LEF1;TRIM37;MLL1;PSIP1;POLD1;SP100;LMO2;EZH1;CBX7 |
| protein binding | DYRK4;TRIM63;N4BP2L2;TNIP3;NR2F1;TAOK3;ADCK5;FAM32A;PIK3R4 |
PAF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PAF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PAF1.
CDC73
- Q&As
- Reviews
Q&As (5)
Ask a questionPAF1 regulates gene expression during stem cell differentiation, impacting cell fate decisions and developmental processes.
PAF1 interacts with various proteins involved in transcriptional regulation, chromatin modification, and cellular signaling, highlighting its multifaceted role in cellular processes.
Preliminary studies suggest that PAF1 expression may be altered in certain autoimmune conditions, warranting further investigation as a potential diagnostic marker.
PAF1 is involved in the transcriptional regulation of immune-related genes, influencing immune system responses and inflammation.
PAF1 is involved in DNA repair mechanisms, and its proper function is crucial for maintaining genomic stability and preventing the accumulation of DNA damage.
Customer Reviews (3)
Write a reviewThe PAF1 Protein's adaptability has significantly expanded the scope of my investigations and broadened the possibilities for my research.
Its versatility and reliability make it a top choice for researchers in various fields.
The PAF1 Protein is an exceptional product that fully meets my experimental needs.
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