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PAPOLA

  • Official Full Name

    poly(A) polymerase alpha

  • Overview

    The protein encoded by this gene belongs to the poly(A) polymerase family. It is required for the addition of adenosine residues for the creation of the 3-poly(A) tail of mRNAs. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    PAPOLA; poly(A) polymerase alpha; PAP; PAP-alpha; polynucleotide adenylyltransferase alpha; MGC5378;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Rhesus Macaque
  • Zebrafish
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PAPOLA-759H Recombinant Human PAPOLA Mammalian Cell His
Human PAPOLA-3791H Recombinant Human PAPOLA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human PAPOLA-3791H-B Recombinant Human PAPOLA Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque PAPOLA-3298R Recombinant Rhesus monkey PAPOLA Protein, His-tagged Mammalian Cell His
Rhesus Macaque PAPOLA-3116R Recombinant Rhesus Macaque PAPOLA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PAPOLA-3116R-B Recombinant Rhesus Macaque PAPOLA Protein Pre-coupled Magnetic Beads HEK293
Zebrafish PAPOLA-11772Z Recombinant Zebrafish PAPOLA Mammalian Cell His
Chicken PAPOLA-4181C Recombinant Chicken PAPOLA Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PAPOLA Related Articles

PAPOLA involved in several pathways and played different roles in them. We selected most pathways PAPOLA participated on our site, such as Cleavage of Growing Transcript in the Termination Region, Gene Expression, Processing of Capped Intron-Containing Pre-mRNA, which may be useful for your reference. Also, other proteins which involved in the same pathway with PAPOLA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cleavage of Growing Transcript in the Termination RegionCSTF2;NUDT21;PAPOLA;LSM10;CSTF1;CSTF3;RNPS1;ZFP473;SLBP
Gene ExpressionDDX4;SSRP1;LBH;PAPOLA;APEH;DNMT3B;SLBP;ZNF12;SF3B2
Processing of Capped Intron-Containing Pre-mRNAHNRNPA0;ZMAT5;U2AF2;METTL3;PTBP1B;HNRNPA0B;CSTF3;PAPOLA;CD2BP2
Processing of Capped Intronless Pre-mRNACSTF2;NUDT21;CSTF1;LSM10;CLP1;ZFP473;ZNF473;PAPOLA;CSTF3
Processing of Intronless Pre-mRNAsPAPOLA;CLP1;CSTF3;CSTF2;NUDT21;CSTF1
RNA Polymerase II TranscriptionPAPOLA;NELFE;CLP1;U2AF2;NUDT21;CCNT2A;LSM11;THOC4;SUPT16H
RNA Polymerase II Transcription TerminationRNPS1;U2AF2;NUDT21;CSTF1;PAPOLA;CSTF2;ZNF473;LSM11;CLP1
TNF-alpha/NF-kB Signaling PathwayTRAIP;DCAF7;DAP;KIAA1967;MARK2;SMARCE1;NR2C2;PFDN2;LRPPRC

PAPOLA has several biochemical functions, for example, ATP binding, RNA binding, magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PAPOLA itself. We selected most functions PAPOLA had, and list some proteins which have the same functions with PAPOLA. You can find most of the proteins on our site.

Function Related Protein
ATP bindingDDX52;AK2;NDUFA13;GRK1A;MYLK2;PSMC1B;MAP2K2B;CKMA;BCS1L
RNA bindingRPL3;DPPA5A;HNRNPA1L2;PABPC1A;APOBEC3F;NANOS1;RNMTL1B;PDCD4;TRIM32
magnesium ion bindingATP11A;COMTA;CIB4;LATS1;SIK2;MARK1;PGP;GTPBP5;PRPS1A
manganese ion bindingHMGCL;CDIPT;DCP2;GALNT3;PPEF2;DYRK2;XPNPEP3;PIM1;GLUL
polynucleotide adenylyltransferase activityPAPOLB;MTPAP;PAPOLG;TUT1;PAPD7;PAPD4;PAPOLA
protein bindingFAM109A;ERG;PRKRIP1;NDRG4;Unc5b;GORASP1;FBXO17;CA2;NEURL1B

PAPOLA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PAPOLA here. Most of them are supplied by our site. Hope this information will be useful for your research of PAPOLA.

Ywhae; PKM; REL; SMAD2; glpD; RSRC1; NPM1; CPSF1; CIRBP; PCBP2

de la Camara, CMF; Olivares-Gonzalez, L; et al. Infliximab reduces Zaprinast-induced retinal degeneration in cultures of porcine retina. JOURNAL OF NEUROINFLAMMATION 11:-(2014).
Meng, XW; Koh, BD; et al. Poly(ADP-ribose) Polymerase Inhibitors Sensitize Cancer Cells to Death Receptor-mediated Apoptosis by Enhancing Death Receptor Expression. JOURNAL OF BIOLOGICAL CHEMISTRY 289:20543-20558(2014).
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