PAPOLA
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Official Full Name
poly(A) polymerase alpha -
Overview
The protein encoded by this gene belongs to the poly(A) polymerase family. It is required for the addition of adenosine residues for the creation of the 3-poly(A) tail of mRNAs. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
PAPOLA;poly(A) polymerase alpha;PAP;PAP-alpha;polynucleotide adenylyltransferase alpha;MGC5378
Recombinant Proteins
- Zebrafish
- Rhesus macaque
- Chicken
- Human
- Mammalian Cells
- HEK293
- His
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PAPOLA-11772Z | Recombinant Zebrafish PAPOLA | Mammalian Cells | Zebrafish | His |
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| PAPOLA-3298R | Recombinant Rhesus monkey PAPOLA Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
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| PAPOLA-4181C | Recombinant Chicken PAPOLA | Mammalian Cells | Chicken | His |
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| PAPOLA-759H | Recombinant Human PAPOLA | Mammalian Cells | Human | His |
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| PAPOLA-3116R | Recombinant Rhesus Macaque PAPOLA Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | Avi&Fc&His |
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| PAPOLA-3116R-B | Recombinant Rhesus Macaque PAPOLA Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| PAPOLA-3791H | Recombinant Human PAPOLA Protein, His (Fc)-Avi-tagged | HEK293 | Human | Avi&Fc&His |
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| PAPOLA-3791H-B | Recombinant Human PAPOLA Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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Involved Pathway
PAPOLA involved in several pathways and played different roles in them. We selected most pathways PAPOLA participated on our site, such as Cleavage of Growing Transcript in the Termination Region,Gene Expression,Processing of Capped Intron-Containing Pre-mRNA, which may be useful for your reference. Also, other proteins which involved in the same pathway with PAPOLA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RNA Polymerase II Transcription Termination | ZFP473,ZNF473,LSM11,U2AF2,RNPS1,CLP1,NUDT21,LSM10,SLBP,SRSF11 |
| RNA Polymerase II Transcription | NUDT21,LSM11,CCNT2B,SSRP1A,SLBP,ZFP473,RNPS1,THOC4,CCNT2A,GM3258 |
| Gene Expression | NFIC,TAF1D,TRMT6,IGF2BP1,DPY19L2,USP9X,RARG,ZNF718,RPP40,CPSF4 |
| TNF-alpha/NF-kB Signaling Pathway | UNC5CL,DCAF7,RNF216,KPNA6,PEG3,TRAIP,KIAA1967,TNIP1,FAF1,NKIRAS1 |
| Cleavage of Growing Transcript in the Termination Region | U2AF2,SLBP,CSTF3,NUDT21,LSM10,CSTF1,RNPS1,THOC4,ZFP473,ZNF473 |
| Processing of Capped Intronless Pre-mRNA | CSTF3,CSTF2,NUDT21,CSTF1,ZFP473,LSM11,CLP1,LSM10,SLBP,ZNF473 |
| Processing of Intronless Pre-mRNAs | CSTF3,CSTF1,CSTF2,CLP1,NUDT21 |
| Processing of Capped Intron-Containing Pre-mRNA | HNRNPA2B1,HNRNPD,PTBP1A,PRPF8,ZCRB1,PDCD7,HNRNPH1,SNRNP48,NXF1,SRSF11 |
Protein Function
PAPOLA has several biochemical functions, for example, ATP binding,RNA binding,magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PAPOLA itself. We selected most functions PAPOLA had, and list some proteins which have the same functions with PAPOLA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA binding | PTBP2B,EMG1,BRCA1,PABPC1L2A,FBL,RPL30,RPS4Y1,RBM17,CWC15,FARSB |
| polynucleotide adenylyltransferase activity | PAPD4,TUT1,PAPD7,MTPAP,PAPOLB,PAPOLG |
| ATP binding | EARS2,CAMK1G,BMX,AK3,FIGNL2,PPIP5K1,CLK2B,PRPS1L1,IRAK4,PSTK |
| manganese ion binding | LAP3,FAM20C,DYRK2,HMGCL,NPEPL1,PPM1A,B4GALT1,NUDT16,TDP2,PPM1AA |
| protein binding | NKX3-1,CCDC116,CARM1,MAU2,EGLN1,GPR128,ARPC2,KIAA1609,KIAA1109,MAGEB18 |
| magnesium ion binding | NLK,PPM1AA,PPM1A,RPS6KA3,ADSSL1,PRPS2,THG1L,CIB2,ATP10A,HPRT1 |
Interacting Protein
PAPOLA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PAPOLA here. Most of them are supplied by our site. Hope this information will be useful for your research of PAPOLA.
Ywhae;PKM;REL;SMAD2;glpD;RSRC1;NPM1;CPSF1;CIRBP;PCBP2
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References
- de la Camara, CMF; Olivares-Gonzalez, L; et al. Infliximab reduces Zaprinast-induced retinal degeneration in cultures of porcine retina. JOURNAL OF NEUROINFLAMMATION 11:-(2014).
- Meng, XW; Koh, BD; et al. Poly(ADP-ribose) Polymerase Inhibitors Sensitize Cancer Cells to Death Receptor-mediated Apoptosis by Enhancing Death Receptor Expression. JOURNAL OF BIOLOGICAL CHEMISTRY 289:20543-20558(2014).
