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PAPPA2

Official Full Name

pappalysin 2
Overview

This gene encodes a member of the pappalysin family of metzincin metalloproteinases. The encoded protein cleaves insulin-like growth factor-binding protein 5 and is thought to be a local regulator of insulin-like growth factor (IGF) bioavailability. Alternative splicing results in multiple transcript variants.
Synonyms

PAPPA2; pappalysin 2; PLAC3, placenta specific 3; pappalysin-2; PAPP A2; PAPPE; PAPP-E; placenta-specific 3; pregnancy-associated plasma protein E1; pregnancy-associated plasma preproprotein-A2; PLAC3; PAPP-A2;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	PAPPA2-8058H	Recombinant Human PAPPA2 protein, His-tagged	E.coli	His	Gly888~Ala1093 (Accession # Q9BXP8)	Inquiry
Human	PAPPA2-821H	Recombinant Human PAPPA2 protein(Ser234-Cys1396), His-tagged	HEK293	C-His	Ser234-Cys1396	$498 / 20 µg
Human	PAPPA2-8059H	Recombinant Human PAPPA2 protein, His-tagged	E.coli	His	His1309~Ser1492 (Accession # Q9BXP8)	Inquiry
Human	PAPPA2-2876HCL	Recombinant Human PAPPA2 cell lysate	Human Cell	N/A		Inquiry
Human	PAPPA2-5071H	Recombinant Human PAPPA2 Protein (Ser234-Cys1396), N-His tagged	E.coli	N-His	Ser234-Cys1396	Inquiry

Involved Pathway
Protein Function
Interacting Protein
PAPPA2 Related Research Area

PAPPA2 involved in several pathways and played different roles in them. We selected most pathways PAPPA2 participated on our site, such as Metabolism of proteins, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), which may be useful for your reference. Also, other proteins which involved in the same pathway with PAPPA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Metabolism of proteins	ADAMTS20;GALNT6;MTX2;YKT6;EXOSC8;NSFB;LMAN2L;FXC1;NAPAA
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	IGFBP6;IGFBP6B;IGFBP6A;IGFBP5;IGFBP5B;GZMH;IGFALS;KLK13;PAPPA2

PAPPA2 has several biochemical functions, for example, metallopeptidase activity, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PAPPA2 itself. We selected most functions PAPPA2 had, and list some proteins which have the same functions with PAPPA2. You can find most of the proteins on our site.

Function	Related Protein
metallopeptidase activity	ANPEP;ADAM21;CHMP1A;CLCA1;MMP1A;ERMP1;AQPEP;ADAMTS13;ADAM10B
zinc ion binding	BBOX1;NR2E3;APOBEC3C;ANKIB1A;CA1;ZZZ3;RFWD3;ADAMTS4;CPB2

PAPPA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PAPPA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PAPPA2.

SMAD4; ATF7IP; ZNF512B

Metalloproteases and Regulators