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PCCB

  • Official Full Name

    propionyl CoA carboxylase, beta polypeptide

  • Overview

    The protein encoded by this gene is a subunit of the propionyl-CoA carboxylase (PCC) enzyme, which is involved in the catabolism of propionyl-CoA. PCC is a mitochondrial enzyme that probably acts as a dodecamer of six alpha subunits and six beta subunits. This gene encodes the beta subunit of PCC. Defects in this gene are a cause of propionic acidemia type II (PA-2). Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    PCCB; propionyl CoA carboxylase, beta polypeptide; propionyl Coenzyme A carboxylase, beta polypeptide; propionyl-CoA carboxylase beta chain, mitochondrial; mitochondrial; PCCase subunit beta; PCCB_HUMAN; pccBC Complementation group; Propanoyl CoA:carbon dioxide ligase subunit beta; Propanoyl-CoA:carbon dioxide ligase subunit beta; Propionyl CoA carboxylase beta chain, mitochondrial; Propionyl-CoA carboxylase , beta subunit; Propionyl-CoA carboxylase beta chain; R74805;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PCCB-1550H Recombinant Human PCCB, GST-tagged E.coli GST C-term-300aa
Human PCCB-1291HCL Recombinant Human PCCB cell lysate N/A
Human PCCB-2553H Recombinant Human PCCB Protein, His-tagged E.coli N-His Glu309-His534
Mouse PCCB-12417M Recombinant Mouse PCCB Protein Mammalian Cell His
Mouse Pccb-8177M Recombinant Mouse Pccb protein, His & T7-tagged E.coli His/T7 Glu311~Leu541 (Accession # Q7TMF4)
Mouse PCCB-6535M-B Recombinant Mouse PCCB Protein Pre-coupled Magnetic Beads HEK293
Mouse PCCB-6535M Recombinant Mouse PCCB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PCCB-3318R Recombinant Rhesus monkey PCCB Protein, His-tagged Mammalian Cell His
Rhesus Macaque PCCB-3136R Recombinant Rhesus Macaque PCCB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PCCB-3136R-B Recombinant Rhesus Macaque PCCB Protein Pre-coupled Magnetic Beads HEK293
Zebrafish PCCB-12178Z Recombinant Zebrafish PCCB Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PCCB Related Articles

PCCB involved in several pathways and played different roles in them. We selected most pathways PCCB participated on our site, such as Valine, leucine and isoleucine degradation, Glyoxylate and dicarboxylate metabolism, Propanoate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PCCB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Valine, leucine and isoleucine degradationALDH9A1;HADHAB;HADHAA;BCAT2;HIBADHB;ALDH9A1B;ALDH3A2A;MCCC1;ALDH9A1A.1
Glyoxylate and dicarboxylate metabolismGLULC;AMT;SHMT2;HYI;SHMT1;PCCB;HAO2;ACAT1;GRHPRA
Propanoate metabolismSUCLG2;HADHAB;LDHAL6A;MUT;MCEE;ACSS2;MLYCD;LDHB;ACADM
Metabolic pathwaysALPI.1;ANPEPB;PLCH1;UMPS;AGMAT;B3GNT2B;HPGDS;ATP5D;MGAT3
Carbon metabolismHADHAA;FBP1;GOT2A;PDHA1;PRPS1A;FH;ACO2;GLDC;RPE

PCCB has several biochemical functions, for example, ATP binding, propionyl-CoA carboxylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PCCB itself. We selected most functions PCCB had, and list some proteins which have the same functions with PCCB. You can find most of the proteins on our site.

Function Related Protein
ATP bindingGRK7;ACTC1B;LYN;MERTK;HK2;EHD3;PDPK1;ITGB1BP3;SMC5
propionyl-CoA carboxylase activityPCCA;PCCB

PCCB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PCCB here. Most of them are supplied by our site. Hope this information will be useful for your research of PCCB.

CSNK2B; INPPL1; US11; IFIT1; k7_vaccw; PPP2R2B; ICT1; EBNA-LP

Stadler, SC; Polanetz, R; et al. Mitochondrial targeting signals and mature peptides of 3-methylcrotonyl-CoA carboxylase. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 334:939-946(2005).
Muro, S; Perez, B; et al. Effect of PCCB gene mutations on the heteromeric and homomeric assembly of Propionyl-CoA carboxylase. MOLECULAR GENETICS AND METABOLISM 74:476-483(2001).
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