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PCDHB15

Official Full Name

protocadherin beta 15
Overview

This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3 exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections.
Synonyms

PCDHB15; protocadherin beta 15; protocadherin beta-15; PCDH BETA15; PCDHB 15; PCDH-beta-15; OTTHUMP00000160009; PCDH-BETA15;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Human
Mouse

Source

E.coli
HEK293

Tag

GST
His
His|T7
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	PCDHB15-1564H	Recombinant Human PCDHB15, GST-tagged	E.coli	GST	31-371aa	$319 / 25ug
Human	PCDHB15-1127H	Recombinant Human PCDHB15 protein, His & T7-tagged	E.coli	His/T7	Val35~Leu347 (Accession # Q9Y5E8)	Inquiry
Human	PCDHB15-3392HCL	Recombinant Human PCDHB15 293 Cell Lysate	HEK293	N/A		Inquiry
Human	PCDHB15-3830H	Recombinant Human PCDHB15 protein, His-tagged	E.coli	His	31-371 aa	$319 / 25ug
Human	PCDHB15-5011H	Recombinant Human PCDHB15 Protein (Val35-Leu347), N-His tagged	E.coli	N-His	Val35-Leu347	Inquiry
Mouse	Pcdhb15-1128M	Recombinant Mouse Pcdhb15 protein, His & T7-tagged	E.coli	His/T7	Pro45~Phe270 (Accession # Q99PJ1)	Inquiry

Involved Pathway
Protein Function
Interacting Protein
PCDHB15 Related Articles

PCDHB15 involved in several pathways and played different roles in them. We selected most pathways PCDHB15 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PCDHB15 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

PCDHB15 has several biochemical functions, for example, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PCDHB15 itself. We selected most functions PCDHB15 had, and list some proteins which have the same functions with PCDHB15. You can find most of the proteins on our site.

Function	Related Protein
calcium ion binding	CIB2;F9A;PROS1;ITIH1;ACTN3B;NCS1A;PRRG4;PRRG2;CDH12A

PCDHB15 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PCDHB15 here. Most of them are supplied by our site. Hope this information will be useful for your research of PCDHB15.

DERL1; SSR3; c9jaw5_human; NAP1L1; NRD1; HLA-A; PRDX5; SOAT1; PLXNA3; MRPS25; BLMH; GPATCH4; RNF123; CRTC3; C5orf24; NANP; TBCK; CEP192; AP3S1; DPY30

van Helden, YGJ; Godschalk, RWL; et al. Organ specificity of beta-carotene induced lung gene-expression changes in Bcmo1(-/-) mice. MOLECULAR NUTRITION & FOOD RESEARCH 57:307-319(2013).

Lu, CC; Appler, JM; et al. Developmental Profiling of Spiral Ganglion Neurons Reveals Insights into Auditory Circuit Assembly. JOURNAL OF NEUROSCIENCE 31:10903-10918(2011).