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PCGF6

Official Full Name

polycomb group ring finger 6
Overview

The protein encoded by this gene contains a RING finger motif, which is most closely related to those of polycomb group (PcG) proteins RNF110/MEL-18 and BMI1. PcG proteins are known to form protein complexes and function as transcription repressors. This protein has been shown to interact with some PcG proteins and act as a transcription repressor. The activity of this protein is found to be regulated by cell cycle dependent phosphorylation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Synonyms

PCGF6; polycomb group ring finger 6; MBLR; RNF134; polycomb group RING finger protein 6; ring finger protein 134; Mel18 and Bmi1-like RING finger protein;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat
Rhesus Macaque
Zebrafish

Source

HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	PCGF6-1310HCL	Recombinant Human PCGF6 cell lysate		N/A	Inquiry
Mouse	PCGF6-12493M	Recombinant Mouse PCGF6 Protein	Mammalian Cell	His	Inquiry
Mouse	PCGF6-6551M-B	Recombinant Mouse PCGF6 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Mouse	PCGF6-6551M	Recombinant Mouse PCGF6 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Rat	PCGF6-4298R	Recombinant Rat PCGF6 Protein	Mammalian Cell	His	Inquiry
Rat	PCGF6-3960R-B	Recombinant Rat PCGF6 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Rat	PCGF6-3960R	Recombinant Rat PCGF6 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Rhesus Macaque	PCGF6-3326R	Recombinant Rhesus monkey PCGF6 Protein, His-tagged	Mammalian Cell	His	Inquiry
Rhesus Macaque	PCGF6-3144R	Recombinant Rhesus Macaque PCGF6 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Rhesus Macaque	PCGF6-3144R-B	Recombinant Rhesus Macaque PCGF6 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Zebrafish	PCGF6-5521Z	Recombinant Zebrafish PCGF6	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein

PCGF6 involved in several pathways and played different roles in them. We selected most pathways PCGF6 participated on our site, such as Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with PCGF6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Signaling pathways regulating pluripotency of stem cells	WNT6;SOX2;SMAD9;BMI1;WNT2;WNT5A;PIK3CG;AXIN1;GRB2

PCGF6 has several biochemical functions, for example, DNA binding, RNA polymerase II regulatory region sequence-specific DNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PCGF6 itself. We selected most functions PCGF6 had, and list some proteins which have the same functions with PCGF6. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	HOXA5A;MBD3;H2BFWT;ZNF292A;FOXM1;FEZF1;HIST2H3C;HEMK1;STRBP
RNA polymerase II regulatory region sequence-specific DNA binding	TAL1;RUNX3;AEBP1;BARX1;TRPS1;ATF4B2;BARX2;TBX5;PCGF6
protein binding	ADAMTS13;ENDOG;ZSCAN21;GLIS2;TCTEX1D1;PEX19;CPNE1;CLK1;TMEM123
transcription factor activity, sequence-specific DNA binding	HOXD3A;PRDM1;NR1D2A;Trl;FOXG1A;GLI4;RORAB;POU3F1;HSF4
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding	E4F1;ETV3;E2F7;ZBTB4;MITF;MNT;DMBX1;FOXO3;GLIS1
zinc ion binding	HIF1AN;EHMT1;UBOX5;MGRN1B;MSRB1;LIMK1A;RXRAB;TRIM35-27;MSL2

PCGF6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PCGF6 here. Most of them are supplied by our site. Hope this information will be useful for your research of PCGF6.

RNF2; Cbx7; CBX7; CBX8; CBX4; CBX6; HSP90AB1; PRKAB1; PEX10; TULP3; RING1; UBE2U; PNMA1; RAD18; Ring1