PCK2
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Official Full Name
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
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Overview
This gene encodes a mitochondrial enzyme that catalyzes the conversion of oxaloacetate to phosphoenolpyruvate in the presence of guanosine triphosphate (GTP). A cytosolic form of this protein is encoded by a different gene and is the key enzyme of gluconeogenesis in the liver. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2014] -
Synonyms
PCK2; phosphoenolpyruvate carboxykinase 2 (mitochondrial); PEPCK; PEPCK2; PEPCK-M; phosphoenolpyruvate carboxykinase [GTP], mitochondrial; PEP carboxykinase; phosphopyruvate carboxylase; phosphoenolpyruvate carboxylase;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Rhesus Macaque
- Zebrafish
- E. coli
- E.coli
- HEK293
- Insect Cell
- Mammalian Cell
- GST
- His
- His (Fc)
- Avi
- His|GST
- N/A
- N
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | PCK2-8087H | Recombinant Human PCK2 protein, His-tagged | E.coli | His | Leu33~Val198 | |
Human | PCK2-3378HCL | Recombinant Human PCK2 293 Cell Lysate | HEK293 | N/A | ||
Human | PCK2-3016H | Recombinant Human PCK2 protein, His-tagged | E. coli | His | 292-640 aa | |
Human | PCK2-513H | Recombinant Human PCK2 Protein, His/GST-tagged | Insect Cell | His/GST | Leu33-Met640 | |
Human | PCK2-4810H | Recombinant Human PCK2 Protein (Ala292-Met640), N-His tagged | E.coli | N-His | Ala292-Met640 | |
Human | PCK2-3280H | Recombinant Human PCK2 protein, GST-tagged | E. coli | GST | 292-640 aa | |
Rhesus Macaque | PCK2-3327R | Recombinant Rhesus monkey PCK2 Protein, His-tagged | Mammalian Cell | His | ||
Rhesus Macaque | PCK2-3145R | Recombinant Rhesus Macaque PCK2 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rhesus Macaque | PCK2-3145R-B | Recombinant Rhesus Macaque PCK2 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Zebrafish | PCK2-12403Z | Recombinant Zebrafish PCK2 | Mammalian Cell | His | ||
Chicken | PCK2-7019C | Recombinant Chicken PCK2 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
PCK2 involved in several pathways and played different roles in them. We selected most pathways PCK2 participated on our site, such as Glycolysis / Gluconeogenesis, Citrate cycle (TCA cycle), Pyruvate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PCK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Glycolysis / Gluconeogenesis | AKR1A1B;ALDOA;LDHAL6A;PFKL;LDHAL6B;GALM;ALDOCA;PKLR;GPIA |
Citrate cycle (TCA cycle) | SUCLG2;ACO1;PDHA2;ACLYA;PDHA1;PDHA1A;PDHB;IDH3G;SDHC |
Pyruvate metabolism | ALDH2;LDHBB;ME3;ACACA;ALDH1B1;ALDH9A1A.1;PDK3B;ACOT12;LDHBA |
Metabolic pathways | ADH1B;GPAT2;SI;TKTL1;CYP2C45;ACMSD;ACSL4;NME4;PLD3 |
PPAR signaling pathway | SLC27A5;PPARA;ACOX2;ANGPTL4;SLC27A1B;AQP7;APOC3;ACSBG2;ACSL5 |
FoxO signaling pathway | MAPK10;MAPK13;PIK3R5;G6PC2;CCND2A;TGFBR1B;PRKAG3;PRKAB1;HOMER1B |
PIK-Akt signaling pathway | Reln;STK11;PKN3;ITGA9;IL4R;NR4A1;PKN1;IL2RG;IFNA14 |
AMPK signaling pathway | CREB3;PPP2R3C;PPP2CA;CAB39;RAB2A;G6PC3;MAP3K7;Scd1;PPP2R1A |
Insulin signaling pathway | GRB2A;CALM2B;G6PCA.2;PRKAG3B;INSRB;INPPL1;CALM1A;NRAS;MKNK1 |
Adipocytokine signaling pathway | RXRAA;CPT1C;PRKCQ;IKBKB;SOCS3B;ACSL4B;PPARGC1A;AGRP;IRS4 |
Insulin resistance | NFKBIA;PIK3CD;MGEA5;PRKCBB;IRS2;PYGB;PTPRF;SREBF1;PDPK1 |
Proximal tubule bicarbonate reclamation | SLC9A3;Car2;GLS;ATP1B4;ATP1A1;CA2;SLC25A10;CA4;GLUD2 |
PCK2 has several biochemical functions, for example, GTP binding, metal ion binding, phosphoenolpyruvate carboxykinase (GTP) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PCK2 itself. We selected most functions PCK2 had, and list some proteins which have the same functions with PCK2. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
GTP binding | RAB42A;EEF2A.2;GNA11B;ARF6B;RHOAE;EEF1A1L2;ATL2;GNL3;MFN1B |
metal ion binding | CYP3C1;ATP1A3B;ZBTB2;NEK11;DNAJC21;AMDHD1;AGFG1B;EFCAB11;ITGA1 |
phosphoenolpyruvate carboxykinase (GTP) activity | PCK2;PCK1 |
phosphoenolpyruvate carboxykinase activity | PDXDC1;PCK2 |
protein binding | SPRYD7;SORT1;Clec4n;NCKIPSD;UBE2V1;RPL23;NSL1;SH3RF1;CSNK2A1 |
PCK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PCK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PCK2.
SMAD3; EP300; mhpC2; q81la6_bacan; q81pd4_bacan; icc; def; ere_dna; PROSC; HSPD1; PRCC; TSG101; MUC13; CWC15; SIRT4
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