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PCK2

  • Official Full Name

    phosphoenolpyruvate carboxykinase 2 (mitochondrial)

  • Overview

    This gene encodes a mitochondrial enzyme that catalyzes the conversion of oxaloacetate to phosphoenolpyruvate in the presence of guanosine triphosphate (GTP). A cytosolic form of this protein is encoded by a different gene and is the key enzyme of gluconeogenesis in the liver. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2014]
  • Synonyms

    PCK2; phosphoenolpyruvate carboxykinase 2 (mitochondrial); PEPCK; PEPCK2; PEPCK-M; phosphoenolpyruvate carboxykinase [GTP], mitochondrial; PEP carboxykinase; phosphopyruvate carboxylase; phosphoenolpyruvate carboxylase;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Rhesus Macaque
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • Insect Cell
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PCK2-8087H Recombinant Human PCK2 protein, His-tagged E.coli His Leu33~Val198
Human PCK2-3378HCL Recombinant Human PCK2 293 Cell Lysate HEK293 N/A
Human PCK2-3016H Recombinant Human PCK2 protein, His-tagged E. coli His 292-640 aa
Human PCK2-513H Recombinant Human PCK2 Protein, His/GST-tagged Insect Cell His/GST Leu33-Met640
Human PCK2-4810H Recombinant Human PCK2 Protein (Ala292-Met640), N-His tagged E.coli N-His Ala292-Met640
Human PCK2-3280H Recombinant Human PCK2 protein, GST-tagged E. coli GST 292-640 aa
Rhesus Macaque PCK2-3327R Recombinant Rhesus monkey PCK2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque PCK2-3145R Recombinant Rhesus Macaque PCK2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PCK2-3145R-B Recombinant Rhesus Macaque PCK2 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish PCK2-12403Z Recombinant Zebrafish PCK2 Mammalian Cell His
Chicken PCK2-7019C Recombinant Chicken PCK2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

PCK2 involved in several pathways and played different roles in them. We selected most pathways PCK2 participated on our site, such as Glycolysis / Gluconeogenesis, Citrate cycle (TCA cycle), Pyruvate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PCK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Glycolysis / GluconeogenesisAKR1A1B;ALDOA;LDHAL6A;PFKL;LDHAL6B;GALM;ALDOCA;PKLR;GPIA
Citrate cycle (TCA cycle)SUCLG2;ACO1;PDHA2;ACLYA;PDHA1;PDHA1A;PDHB;IDH3G;SDHC
Pyruvate metabolismALDH2;LDHBB;ME3;ACACA;ALDH1B1;ALDH9A1A.1;PDK3B;ACOT12;LDHBA
Metabolic pathwaysADH1B;GPAT2;SI;TKTL1;CYP2C45;ACMSD;ACSL4;NME4;PLD3
PPAR signaling pathwaySLC27A5;PPARA;ACOX2;ANGPTL4;SLC27A1B;AQP7;APOC3;ACSBG2;ACSL5
FoxO signaling pathwayMAPK10;MAPK13;PIK3R5;G6PC2;CCND2A;TGFBR1B;PRKAG3;PRKAB1;HOMER1B
PIK-Akt signaling pathwayReln;STK11;PKN3;ITGA9;IL4R;NR4A1;PKN1;IL2RG;IFNA14
AMPK signaling pathwayCREB3;PPP2R3C;PPP2CA;CAB39;RAB2A;G6PC3;MAP3K7;Scd1;PPP2R1A
Insulin signaling pathwayGRB2A;CALM2B;G6PCA.2;PRKAG3B;INSRB;INPPL1;CALM1A;NRAS;MKNK1
Adipocytokine signaling pathwayRXRAA;CPT1C;PRKCQ;IKBKB;SOCS3B;ACSL4B;PPARGC1A;AGRP;IRS4
Insulin resistanceNFKBIA;PIK3CD;MGEA5;PRKCBB;IRS2;PYGB;PTPRF;SREBF1;PDPK1
Proximal tubule bicarbonate reclamationSLC9A3;Car2;GLS;ATP1B4;ATP1A1;CA2;SLC25A10;CA4;GLUD2

PCK2 has several biochemical functions, for example, GTP binding, metal ion binding, phosphoenolpyruvate carboxykinase (GTP) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PCK2 itself. We selected most functions PCK2 had, and list some proteins which have the same functions with PCK2. You can find most of the proteins on our site.

Function Related Protein
GTP bindingRAB42A;EEF2A.2;GNA11B;ARF6B;RHOAE;EEF1A1L2;ATL2;GNL3;MFN1B
metal ion bindingCYP3C1;ATP1A3B;ZBTB2;NEK11;DNAJC21;AMDHD1;AGFG1B;EFCAB11;ITGA1
phosphoenolpyruvate carboxykinase (GTP) activityPCK2;PCK1
phosphoenolpyruvate carboxykinase activityPDXDC1;PCK2
protein bindingSPRYD7;SORT1;Clec4n;NCKIPSD;UBE2V1;RPL23;NSL1;SH3RF1;CSNK2A1

PCK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PCK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PCK2.

SMAD3; EP300; mhpC2; q81la6_bacan; q81pd4_bacan; icc; def; ere_dna; PROSC; HSPD1; PRCC; TSG101; MUC13; CWC15; SIRT4

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