PDE4A

  • Official Full Name

    PDE4A phosphodiesterase 4A, cAMP-specific

  • Overview

    Cyclic nucleotide phosphodiesterases (PDEs) catalyse the hydrolytic inactivation of the common intracellular second messengers cyclic adenosine and guanosine 3, 5monophosphate (cAMP and cGMP). Thus, these enzymes play a critical role in the regulation of a wide range of physiological processes modulated by cyclic nucleotide signalling. The PDE4 enzyme belongs to a family of cAMPdependent PDEs that provide the major means of inactivating the key intracellular second messenger, cAMP. Four genes (4A, 4B, 4C, and 4D) encode around 20 distinct isoform members of the PDE4 family. Each isoform is characterized by a unique Nterminal region
  • Synonyms

    PDE4A; phosphodiesterase 4A, cAMP-specific; DPDE2, phosphodiesterase 4A, cAMP specific (dunce (Drosophila) homolog phosphodiesterase E2); cAMP-specific 3,5-cyclic phosphodiesterase 4A; phosphodiesterase E2 dunce homolog (Drosophila); phosphodiesterase isozyme 4; phosphodiesterase 4A, cAMP-specific (dunce; phosphodiesterase E2 dunce homolog, Drosophila; PDE4; DPDE2; PDE46;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Human
  • Mouse
  • Rat
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Sf9 Insect Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PDE4A-1527H Active Recombinant Human PDE4A, GST-tagged Sf9 Insect Cell GST
Human PDE4A-29933TH Recombinant Human PDE4A Wheat Germ N/A
Human PDE4A-475H Recombinant Human PDE4A, GST-tagged, Active Sf9 Insect Cell GST
Human PDE4A-3352HCL Recombinant Human PDE4A 293 Cell Lysate HEK293 N/A
Human PDE4A6948H Recombinant Human PDE4A (352-685).docx Protein
Human PDE4A-366HF Recombinant Full Length Human PDE4A Protein In Vitro Cell Free System
Mouse PDE4A-12553M Recombinant Mouse PDE4A Protein Mammalian Cell His
Mouse Pde4a-4745M Recombinant Mouse Pde4a Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse PDE4A-6584M Recombinant Mouse PDE4A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse PDE4A-6584M-B Recombinant Mouse PDE4A Protein Pre-coupled Magnetic Beads HEK293
Rat PDE4A-4330R Recombinant Rat PDE4A Protein Mammalian Cell His
Rat PDE4A-3990R Recombinant Rat PDE4A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PDE4A-3990R-B Recombinant Rat PDE4A Protein Pre-coupled Magnetic Beads HEK293
Kit-1838 PDE4A Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PDE4A Related Articles
  • PDE4A Related Research Area

PDE4A involved in several pathways and played different roles in them. We selected most pathways PDE4A participated on our site, such as Purine metabolism, cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDE4A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Purine metabolismPOLR2J2;NT5C3L;ADKA;NUDT2;PNP6;ENTPD3;NT5C3B;RRM2B;PKM2
cAMP signaling pathwayATP1B1;ATP1A2;FXYD1;ROCK1;GPR81;GLI1;NFKBIA;RRAS2;RAC1

PDE4A has several biochemical functions, for example, 3,5-cyclic-AMP phosphodiesterase activity, cAMP binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDE4A itself. We selected most functions PDE4A had, and list some proteins which have the same functions with PDE4A. You can find most of the proteins on our site.

Function Related Protein
3,5-cyclic-AMP phosphodiesterase activityPDE4C;PDE8A;PDE7B;PDE1B;PDE8B;PDE4B;PDE4A;USB1;TDP2B
cAMP bindingPDE4A;CNGA4;HCN2;PDE11A;PRKAR1A;POPDC2;PDE10A;PDE4D;PDE4B
metal ion bindingME3;HIVEP2;HDHD1A;GIT2A;MMP1A;ZNF461;NUDT15;PPM1G;ERCC2
protein bindingPMP2;USP20;MED28;AP4B1;C1QA;TRAPPC6B;NTF3;CHUK;TTC37

PDE4A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDE4A here. Most of them are supplied by our site. Hope this information will be useful for your research of PDE4A.

Dlg4; bosutinib; dasatinib; ITPKB

Uckert, S; Waldkirch, ES; et al. Expression and Distribution of Phosphodiesterase Isoenzymes in the Human Seminal Vesicles. JOURNAL OF SEXUAL MEDICINE 8:3058-3065(2011).
Richter, W; Jin, SLC; et al. Splice variants of the cyclic nucleotide phosphodiesterase PDE4D are, differentially expressed and regulated in rat tissue. BIOCHEMICAL JOURNAL 388:803-811(2005).
  • Q&As
  • Reviews

Q&As (6)

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How effective are PDE4A inhibitors in the treatment of asthma? 04/12/2022

The inhibitors have been used in the treatment of asthma, and studies have shown that they can significantly reduce the number of asthma attacks and the use of drug D.

How to introduce the structure of PDE4A? 03/30/2022

This protein has multiple conserved regions and different subtypes, which is of great significance for the selective inhibition of drugs.

What is a selective PDE4A inhibitor? 12/25/2021

Selective PDE4A inhibitors refer to drug molecules that target only the PDE4A protein and do not inhibit other PDE4 homologs.

What is the mechanism by which PDE4A regulates T cell-mediated autoimmune responses? 05/30/2021

It plays an important role in the activation and regulation of T cells by regulating cAMP levels, and is involved in T cell-mediated autoimmune responses.

Are levels of PDE4A associated with sleep disturbances? 02/12/2021

Studies have shown that PDE4A depletion may be related to sleep-wake behavior and time stress response, but its specific role needs to be further studied.

What is the expression pattern of PDE4A in T cells? 08/27/2020

In T cells, PDE4A is mainly expressed in the cytoplasm and peripheral regions of the nuclear membrane.

Customer Reviews (3)

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Reviews
12/05/2022

    PDE4A requires less storage environment.

    07/26/2022

      The expression of PDE4A was stable.

      02/08/2022

        It has the advantage of easy operation in the expression system and can improve the expression efficiency.

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