• Official Full Name

    PDE4A phosphodiesterase 4A, cAMP-specific

  • Background

    Cyclic nucleotide phosphodiesterases (PDEs) catalyse the hydrolytic inactivation of the common intracellular second messengers cyclic adenosine and guanosine 3, 5monophosphate (cAMP and cGMP). Thus, these enzymes play a critical role in the regulation of a wide range of physiological processes modulated by cyclic nucleotide signalling. The PDE4 enzyme belongs to a family of cAMPdependent PDEs that provide the major means of inactivating the key intracellular second messenger, cAMP. Four genes (4A, 4B, 4C, and 4D) encode around 20 distinct isoform members of the PDE4 family. Each isoform is characterized by a unique Nterminal region
  • Synonyms

    PDE4A; phosphodiesterase 4A, cAMP-specific; DPDE2, phosphodiesterase 4A, cAMP specific (dunce (Drosophila) homolog phosphodiesterase E2); cAMP-specific 3,5-cyclic phosphodiesterase 4A; phosphodiesterase E2 dunce homolog (Drosophila); phosphodiesterase isozyme 4; phosphodiesterase 4A, cAMP-specific (dunce; phosphodiesterase E2 dunce homolog, Drosophila; PDE4; DPDE2; PDE46;
    • Type:
    • Assay Kits
    • Cell & Tissue Lysates
    • Recombinant Proteins
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • His (Fc)
    • Avi
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Kit-1838 PDE4A Assay Kit N/A
    Human PDE4A-3352HCL Recombinant Human PDE4A 293 Cell Lysate HEK293 N/A
    Human PDE4A-29933TH Recombinant Human PDE4A Wheat Germ N/A
    Human PDE4A6948H Recombinant Human PDE4A (352-685).docx Protein
    Human PDE4A-1527H Active Recombinant Human PDE4A (Active), GST-tagged Sf9 Insect Cell GST
    Human PDE4A-475H Recombinant Human PDE4A, GST-tagged, Active Sf9 Insect Cell GST
    Mouse Pde4a-4745M Recombinant Mouse Pde4a Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse PDE4A-12553M Recombinant Mouse PDE4A Protein Mammalian Cell His
    Mouse PDE4A-6584M Recombinant Mouse PDE4A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Mouse PDE4A-6584M-B Recombinant Mouse PDE4A Protein Pre-coupled Magnetic Beads HEK293
    Rat PDE4A-3990R Recombinant Rat PDE4A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rat PDE4A-3990R-B Recombinant Rat PDE4A Protein Pre-coupled Magnetic Beads HEK293
    Rat PDE4A-4330R Recombinant Rat PDE4A Protein Mammalian Cell His
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • PDE4A Related Articles
    • PDE4A Related Research Area

    PDE4A involved in several pathways and played different roles in them. We selected most pathways PDE4A participated on our site, such as Purine metabolism, cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDE4A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Purine metabolismAMPD3B;PDE4D;AK3;GMPR;ENTPD5;FHIT;AMPD2;POLE4;AK7

    PDE4A has several biochemical functions, for example, 3,5-cyclic-AMP phosphodiesterase activity, cAMP binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDE4A itself. We selected most functions PDE4A had, and list some proteins which have the same functions with PDE4A. You can find most of the proteins on our site.

    Function Related Protein
    3,5-cyclic-AMP phosphodiesterase activityPDE3A;PDE4D;PDE1B;PDE4A;PDE7A;PDE8A;PDE4B;TDP2B;PDE7B
    metal ion bindingLIMCH1A;RNF11B;LDB3A;PVALB2;RPE65B;ZNF654;METAP2B;HPX;ZFP36L1
    protein bindingPSMG2;PCID2;AP1G2;NXF2;IL2RB;PABPC1;ATF4;MTAP;ANXA11

    PDE4A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDE4A here. Most of them are supplied by our site. Hope this information will be useful for your research of PDE4A.

    Dlg4; bosutinib; dasatinib; ITPKB

    Uckert, S; Waldkirch, ES; et al. Expression and Distribution of Phosphodiesterase Isoenzymes in the Human Seminal Vesicles. JOURNAL OF SEXUAL MEDICINE 8:3058-3065(2011).
    Richter, W; Jin, SLC; et al. Splice variants of the cyclic nucleotide phosphodiesterase PDE4D are, differentially expressed and regulated in rat tissue. BIOCHEMICAL JOURNAL 388:803-811(2005).
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