PDE4A involved in several pathways and played different roles in them. We selected most pathways PDE4A participated on our site, such as Purine metabolism, cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDE4A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name |
Pathway Related Protein |
| Purine metabolism |
POLR2GL; POLR2J2; AK7B; GUK1A; GC2; POLR2H; PAPSS2; APRT; PAPSS2B; PKLR |
| cAMP signaling pathway |
BRAF; ATP1B4; NFATC1; RHOA; CAMK2G; ATP1A2; PAK1; PDE4B; PTGER3; NFKBIA |
PDE4A has several biochemical functions, for example, 3,5-cyclic-AMP phosphodiesterase activity, cAMP binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDE4A itself. We selected most functions PDE4A had, and list some proteins which have the same functions with PDE4A. You can find most of the proteins on our site.
| Function |
Related Protein |
| 3,5-cyclic-AMP phosphodiesterase activity |
PDE4C; PDE1B; USB1; TDP2B; PDE7A; PDE7B; PDE8B; PDE4D; PDE4A; PDE3A |
| cAMP binding |
PRKAR2A; PRKAR2B; PDE3A; RAPGEF3; PDE4B; HCN2; PDE4D; PDE2A; BVES; CNMPD1 |
| metal ion binding |
ZSCAN20; ZNF148; ZNF256; ALOX5B.2; ADCY3; SUZ12; ZNF486; CPS1; ZBED6; CASZ1 |
| protein binding |
HER5; RIMS2; PLIN1; RCOR1; BRD9; BLOC1S2A; CEP290; SH2B2; IL10RB; OBFC2B |
PDE4A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDE4A here. Most of them are supplied by our site. Hope this information will be useful for your research of PDE4A.
Dlg4; bosutinib; dasatinib; ITPKB
Uckert, S; Waldkirch, ES; et al. Expression and Distribution of Phosphodiesterase Isoenzymes in the Human Seminal Vesicles. JOURNAL OF SEXUAL MEDICINE 8:3058-3065(2011).
Richter, W; Jin, SLC; et al. Splice variants of the cyclic nucleotide phosphodiesterase PDE4D are, differentially expressed and regulated in rat tissue. BIOCHEMICAL JOURNAL 388:803-811(2005).
