Recombinant Human PDE4A, GST-tagged, Active
Cat.No. : | PDE4A-475H |
Product Overview : | Recombinanthuman PDE4A (332-end) was expressed bybaculovirusinSf9 insect cellsusing an N-terminal GST tag. MW=110kDa. |
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Cat. No. : | PDE4A-475H |
Description : | PDE4A is a member of the phosphodiesterase family of proteins that play a critical role in regulating intracellular levels of cAMP. In vitro phosphorylation of PDE4A by the PKA-catalytic subunit increases the enzyme"s sensitivity to Mg2+, leading to a 4-fold increase in cAMP hydrolysis without affecting the Km. PDE4 is widely expressed in brain tumors and promotes their growth and treatment with PDE4A inhibitor Rolipram overcomes tumor resistance and mediates tumor regression. PDE4A expression is altered in patients with bipolar disorder and is a new therapeutic avenue for treatment of this disorder. |
Source : | Sf9 insect cells using baculovirus. |
Sequence : | 332-end. |
Applications : | PDE Assay. |
Storage And Stability : | Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
22q13.33 : | 19p13.2 |
Protein length : | 332-end |
Gene Name : | PDE4A phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila) [ Homo sapiens ] |
Synonyms : | PDE4A; phosphodiesterase 4A, calmodulin-dependent; cAMP-specific phosphodiesterase; phosphodiesterase 4A; phosphodiesterase 4A, cAMP-specific (dunce; phosphodiesterase E2 dunce homolog, Drosophila; phosphodiesterase isozyme 4; PDE4; DPDE2; PDE46; EC 3.1.4.17 |
Gene ID : | 5141 |
mRNA Refseq : | NM_001111307 |
Protein Refseq : | NP_001104777 |
MIM : | 600126 |
UniProt ID : | P27815 |
Pathway : | Progesterone-mediated oocyte maturation; Purine metabolism; Signaling by GPCR; Insulin signaling pathway |
Function : | 3",5"-cyclic-AMP phosphodiesterase activity; cGMP-inhibited cyclic-nucleotide phosphodiesterase activity; hydrolase activity |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewPDE4A requires less storage environment.
The expression of PDE4A was stable.
It has the advantage of easy operation in the expression system and can improve the expression efficiency.
Q&As (6)
Ask a questionThe inhibitors have been used in the treatment of asthma, and studies have shown that they can significantly reduce the number of asthma attacks and the use of drug D.
This protein has multiple conserved regions and different subtypes, which is of great significance for the selective inhibition of drugs.
Selective PDE4A inhibitors refer to drug molecules that target only the PDE4A protein and do not inhibit other PDE4 homologs.
It plays an important role in the activation and regulation of T cells by regulating cAMP levels, and is involved in T cell-mediated autoimmune responses.
Studies have shown that PDE4A depletion may be related to sleep-wake behavior and time stress response, but its specific role needs to be further studied.
In T cells, PDE4A is mainly expressed in the cytoplasm and peripheral regions of the nuclear membrane.
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