PDE5A

  • Official Full Name

    phosphodiesterase 5A, cGMP-specific

  • Overview

    This gene encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Alternative splicing of this gene results in three transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
  • Synonyms

    PDE5A; phosphodiesterase 5A, cGMP-specific; CN5A; PDE5; CGB-PDE; cGMP-specific 3,5-cyclic phosphodiesterase; phosphodiesterase isozyme 5; cGMP-specific phosphodiesterase PDE5A2; cGMP-specific phosphodiesterase type 5A; cGMP-binding cGMP-specific 3,5-cyclic nucleotide phosphodiesterase;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bovine
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Mammalian Cell
  • Sf9 Insect Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PDE5A-636H Recombinant Human PDE5A Mammalian Cell His
Human PDE5A-479H Recombinant Human PDE5A, GST-tagged, Active Sf9 Insect Cell GST
Human PDE5A-1603H Recombinant Human PDE5A, GST-tagged E.coli GST
Human PDE5A-476H Recombinant Human PDE5A, His-tagged Sf9 Insect Cell His
Human PDE5A-3348HCL Recombinant Human PDE5A 293 Cell Lysate HEK293 N/A
Human PDE5A-2039H Recombinant Human PDE5A Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PDE5A-5233H Recombinant Human PDE5A Protein (Glu321-Lys482), N-His tagged E.coli N-His
Human PDE5A-3816H Recombinant Human PDE5A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human PDE5A-2567H Recombinant Human PDE5A Protein, His-tagged E.coli N-His
Human PDE5A-3816H-B Recombinant Human PDE5A Protein Pre-coupled Magnetic Beads HEK293
Mouse PDE5A-12558M Recombinant Mouse PDE5A Protein Mammalian Cell His
Mouse PDE5A-6587M Recombinant Mouse PDE5A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse PDE5A-6587M-B Recombinant Mouse PDE5A Protein Pre-coupled Magnetic Beads HEK293
Mouse Pde5a-4748M Recombinant Mouse Pde5a Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Pde5a-4612M Recombinant Mouse Pde5a protein, His&Myc-tagged E.coli His&Myc
Rat PDE5A-4334R Recombinant Rat PDE5A Protein Mammalian Cell His
Rat PDE5A-3994R-B Recombinant Rat PDE5A Protein Pre-coupled Magnetic Beads HEK293
Rat PDE5A-3994R Recombinant Rat PDE5A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Bovine PDE5A-640B Recombinant Bovine Phosphodiesterase 5A, cGMP-specific Insect Cell N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PDE5A Related Research Area

PDE5A involved in several pathways and played different roles in them. We selected most pathways PDE5A participated on our site, such as Purine metabolism, cGMP-PKG signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDE5A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Purine metabolismPAPSS1;GART;NUDT5;NT5C1B-RDH14;AK7B;NME7;ENTPD1;POLR2F;RRM2
cGMP-PKG signaling pathwayVDAC3;ATP1B3;GNA12;CREB3L1;GNAI2;SLC8A2;PIK3R3;PDE2A;ATP1B4

PDE5A has several biochemical functions, for example, 3,5-cyclic-GMP phosphodiesterase activity, 3,5-cyclic-nucleotide phosphodiesterase activity, cGMP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDE5A itself. We selected most functions PDE5A had, and list some proteins which have the same functions with PDE5A. You can find most of the proteins on our site.

Function Related Protein
3,5-cyclic-GMP phosphodiesterase activityPDE6H;PDE5A;PDE6G;PDE9A;PDE10A;PDE6C;PDE11A;PDE6B;PDE6A
3,5-cyclic-nucleotide phosphodiesterase activityPDE3B;PDE10A;PDE11A;PDE5A;PDE9A;PDE6D;PDE8B;PDE8A;PDE4D
cGMP bindingPDE5A;PDE11A;PDE6H;PDE6G;CNGA4;CNGA2;PDE10A;CNGA5;PRKG1
metal ion bindingHDAC7;SALL4;SEMG1;FAHD2B;ZNF292A;EGR2A;ZDHHC18B;RPE65B;GM757

PDE5A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDE5A here. Most of them are supplied by our site. Hope this information will be useful for your research of PDE5A.

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