PDE5A involved in several pathways and played different roles in them. We selected most pathways PDE5A participated on our site, such as Purine metabolism, cGMP-PKG signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDE5A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name |
Pathway Related Protein |
| Purine metabolism |
POLR2J3; TM9SF1; GUCY1B3; ATIC; HDDC3; ADSSL; POLR1B; Adcy4; NT5C2B; GUCY2F |
| cGMP-PKG signaling pathway |
RAF1; PPP1R12A; ATP2A1; CREB3L3; INSR; VDAC3; PRKG1; SLC25A4; NFATC4; GNA12 |
PDE5A has several biochemical functions, for example, 3,5-cyclic-GMP phosphodiesterase activity, 3,5-cyclic-nucleotide phosphodiesterase activity, cGMP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDE5A itself. We selected most functions PDE5A had, and list some proteins which have the same functions with PDE5A. You can find most of the proteins on our site.
| Function |
Related Protein |
| 3,5-cyclic-GMP phosphodiesterase activity |
PDE6A; PDE9A; PDE6H; PDE11A; PDE6C; PDE6B; PDE10A; PDE5A; PDE6G |
| 3,5-cyclic-nucleotide phosphodiesterase activity |
PDE11A; PDE3B; PDE8A; PDE10A; PDE5A; PDE8B; PDE6D; PDE9A; PDE5AB; PDE4D |
| cGMP binding |
PDE6H; PDE11A; PDE6G; CNGA4; CNGA2; PRKG1A; CNGA3; PDE2A; PDE6C; PRKG1 |
| metal ion binding |
GM3258; ERCC5; ZDHHC15A; SP8A; ZDHHC18A; PRUNE2; DICER1; CYP8B2; ANTXR2; GTSF1 |
PDE5A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDE5A here. Most of them are supplied by our site. Hope this information will be useful for your research of PDE5A.
