Recombinant Human PDE5A, His-tagged

Cat.No. : PDE5A-476H
Product Overview : Recombinant Human PDE5A, fused with at the C-terminus to a His-tag, was expressed in Sf9 insect cells.
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Description : This gene encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Alternative splicing of this gene results in three transcript variants encoding distinct isoforms.
Source : Sf9 insect cells
Species : Human
Tag : His
Form : Liquid. In 50mM triethanolamine, pH 7.4, containing 1mM DTT, 100mM NaCl, 20% glycerol.
Purity : ≥95%
Stability : Avoid freeze/thaw cycles.
Storage : -80°C
Gene Name : PDE5A phosphodiesterase 5A, cGMP-specific [ Homo sapiens (human) ]
Official Symbol : PDE5A
Synonyms : PDE5A; phosphodiesterase 5A, cGMP-specific; CN5A; PDE5; PDE5A1; CGB-PDE; cGMP-binding cGMP-specific 3",5"-cyclic nucleotide phosphodiesterase; EC 3.1.4.35; cGMP-binding cGMP-specific phosphodiesterase; phosphodiesterase 5A; cGMP-specific 3",5"-cyclic phosphodiesterase
Gene ID : 8654
mRNA Refseq : NM_001083
Protein Refseq : NP_001074
MIM : 603310
UniProt ID : O76074
Chromosome Location : 4q27
Pathway : Nitric oxide stimulates guanylate cyclase; Purine metabolism; cGMP-PKG signaling pathway
Function : 3",5"-cyclic-GMP phosphodiesterase activity; cGMP binding; metal ion binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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