Recombinant Human PDE5A, His-tagged

• Cat.No.: PDE5A-476H
• Product Overview: Recombinant Human PDE5A, fused with at the C-terminus to a His-tag, was expressed in Sf9 insect cells.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: His
• Description: This gene encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Alternative splicing of this gene results in three transcript variants encoding distinct isoforms.
• Form: Liquid. In 50mM triethanolamine, pH 7.4, containing 1mM DTT, 100mM NaCl, 20% glycerol.
• Purity: ≥95%
• Stability: Avoid freeze/thaw cycles.
• Storage: -80°C

Gene Information

• Gene Name: PDE5A phosphodiesterase 5A, cGMP-specific [ Homo sapiens (human) ]
• Official Symbol: PDE5A
• Synonyms: PDE5A; phosphodiesterase 5A, cGMP-specific; CN5A; PDE5; PDE5A1; CGB-PDE; cGMP-binding cGMP-specific 3",5"-cyclic nucleotide phosphodiesterase; EC 3.1.4.35; cGMP-binding cGMP-specific phosphodiesterase; phosphodiesterase 5A; cGMP-specific 3",5"-cyclic phosphodiesterase
• Gene ID: 8654
• mRNA Refseq: NM_001083
• Protein Refseq: NP_001074
• MIM: 603310
• UniProt ID: O76074
• Chromosome Location: 4q27
• Pathway: Nitric oxide stimulates guanylate cyclase; Purine metabolism; cGMP-PKG signaling pathway
• Function: 3",5"-cyclic-GMP phosphodiesterase activity; cGMP binding; metal ion binding