PDE8B

  • Official Full Name

    phosphodiesterase 8B

  • Overview

    The protein encoded by this gene is a cyclic nucleotide phosphodiesterase (PDE) that catalyzes the hydrolysis of the second messenger cAMP. The encoded protein, which does not hydrolyze cGMP, is resistant to several PDE inhibitors. Defects in this gene are a cause of autosomal dominant striatal degeneration (ADSD). Several transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    PDE8B; phosphodiesterase 8B; high affinity cAMP-specific and IBMX-insensitive 3,5-cyclic phosphodiesterase 8B; hsPDE8B; cell proliferation-inducing gene 22 protein; 3,5 cyclic nucleotide phosphodiesterase 8B; ADSD; PPNAD3; FLJ11212;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PDE8B-1614H Active Recombinant Human PDE8B, GST-tagged Sf9 Insect Cell GST
Human PDE8B-30225TH Recombinant Human PDE8B Sf9 Insect Cell N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein

PDE8B involved in several pathways and played different roles in them. We selected most pathways PDE8B participated on our site, such as Purine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDE8B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Purine metabolismPDE8A;NME5;PKM;GDA;POLR3GL;RRM2;PDE6C;HDDC3;POLR3C

PDE8B has several biochemical functions, for example, 3,5-cyclic-AMP phosphodiesterase activity, 3,5-cyclic-nucleotide phosphodiesterase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDE8B itself. We selected most functions PDE8B had, and list some proteins which have the same functions with PDE8B. You can find most of the proteins on our site.

Function Related Protein
3,5-cyclic-AMP phosphodiesterase activityPDE7B;PDE3A;PDE1B;USB1;PDE4C;PDE4A;PDE8B;PDE4D;PDE4B
3,5-cyclic-nucleotide phosphodiesterase activityPDE10A;PDE8B;PDE5AB;PDE9A;PDE8A;PDE6D;PDE4D;PDE3B;PDE11A
metal ion bindingKEX2;ZFP143;HIVEP2;MLPH;ITGA5;SP2;ZNF692;COL27A1;YY1B

PDE8B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDE8B here. Most of them are supplied by our site. Hope this information will be useful for your research of PDE8B.

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