PDE8B
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Official Full Name
phosphodiesterase 8B -
Overview
The protein encoded by this gene is a cyclic nucleotide phosphodiesterase (PDE) that catalyzes the hydrolysis of the second messenger cAMP. The encoded protein, which does not hydrolyze cGMP, is resistant to several PDE inhibitors. Defects in this gene are a cause of autosomal dominant striatal degeneration (ADSD). Several transcript variants encoding different isoforms have been found for this gene. -
Synonyms
PDE8B;phosphodiesterase 8B;high affinity cAMP-specific and IBMX-insensitive 3,5-cyclic phosphodiesterase 8B;hsPDE8B;cell proliferation-inducing gene 22 protein;3,5 cyclic nucleotide phosphodiesterase 8B;ADSD;PPNAD3;FLJ11212
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PDE8B-1614H |
Active Recombinant Human PDE8B, GST-tagged
|
Sf9 Cells | Human | GST | 113-end |
|
| PDE8B-30225TH | Recombinant Human PDE8B | Sf9 Cells | Human | Non | 773 amino acids |
|
Involved Pathway
PDE8B involved in several pathways and played different roles in them. We selected most pathways PDE8B participated on our site, such as Purine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDE8B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Purine metabolism | POLA2,NT5C1A,NME1-NME2,AK8,POLR2EB,ENPP1,PAPSS2,POLR2I,NT5C1BA,PDE6A |
Protein Function
PDE8B has several biochemical functions, for example, 3,5-cyclic-AMP phosphodiesterase activity,3,5-cyclic-nucleotide phosphodiesterase activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDE8B itself. We selected most functions PDE8B had, and list some proteins which have the same functions with PDE8B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 3,5-cyclic-nucleotide phosphodiesterase activity | PDE10A,PDE4D,PDE3B,PDE11A,PDE9A,PDE5A,PDE5AB,PDE8A,PDE6D |
| metal ion binding | CA4A,ZNF263,ZBTB25,PNLIP,CYP2K19,PRKRIR,XGB,POLL,NUBP1,EGR2 |
| 3,5-cyclic-AMP phosphodiesterase activity | PDE4D,USB1,PDE7B,PDE7A,PDE8A,PDE4A,PDE1B,PDE3A,PDE4C,TDP2B |
Interacting Protein
PDE8B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDE8B here. Most of them are supplied by our site. Hope this information will be useful for your research of PDE8B.
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