Active Recombinant Human PDE8B, GST-tagged

Cat.No. : PDE8B-1614H
Product Overview : Recombinant human PDE8B (113-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
  • Specification
  • Gene Information
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Description : The protein encoded by this gene is a cyclic nucleotide phosphodiesterase (PDE) that catalyzes the hydrolysis of the second messenger cAMP. The encoded protein, which does not hydrolyze cGMP, is resistant to several PDE inhibitors. Defects in this gene are a cause of autosomal dominant striatal degeneration (ADSD). Several transcript variants encoding different isoforms have been found for this gene.
Source : Sf9 insect cells
Species : Human
Tag : GST
Form : Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Bio-activity : 40 nmol/min/mg
Molecular Mass : ~115 kDa
Protein length : 113-end
Purity : >85%
Applications : PDE Assay
Stability : 1 yr at -70oC from date of shipment.
Storage : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration : 0.1 ug/ul
Gene Name : PDE8B phosphodiesterase 8B [ Homo sapiens ]
Official Symbol : PDE8B
Synonyms : PDE8B; phosphodiesterase 8B; high affinity cAMP-specific and IBMX-insensitive 3,5-cyclic phosphodiesterase 8B
Gene ID : 8622
mRNA Refseq : NM_003719
Protein Refseq : NP_003710
MIM : 603390
UniProt ID : O95263
Chromosome Location : 5q13.3
Pathway : G Protein Signaling Pathways; GPCR downstream signaling; Purine metabolism
Function : 3',5'-cyclic-AMP phosphodiesterase activity; 3',5'-cyclic-nucleotide phosphodiesterase activity; metal ion binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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