PDE9A
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Official Full Name
PDE9A phosphodiesterase 9A
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Background
Cyclic nucleotide phosphodiesterases (PDEs) catalyse the hydrolytic inactivation of the common intracellular second messengers cyclic adenosine and guanosine 3, 5monophosphate (cAMP and cGMP). Thus, these enzymes play a critical role in the regulation of a wide range of physiological processes modulated by cyclic nucleotide signalling. The PDE10 enzyme belongs to a family of PDEs that hydrolyse both cAMP and cGMP -
Synonyms
PDE9A; phosphodiesterase 9A; high affinity cGMP-specific 3,5-cyclic phosphodiesterase 9A; phosphodiesterase PDE9A21; CGMP-specific 3,5-cyclic phosphodiesterase type 9; HSPDE9A2; FLJ90181;
- Involved Pathway
- Protein Function
- Interacting Protein
PDE9A involved in several pathways and played different roles in them. We selected most pathways PDE9A participated on our site, such as Purine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDE9A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Purine metabolism | POLR1C;NME1-NME2;POLR2J;PGM1;XDH;IMPDH1B;PKM;POLE2;ENTPD3 |
PDE9A has several biochemical functions, for example, 3,5-cyclic-GMP phosphodiesterase activity, 3,5-cyclic-nucleotide phosphodiesterase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDE9A itself. We selected most functions PDE9A had, and list some proteins which have the same functions with PDE9A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 3,5-cyclic-GMP phosphodiesterase activity | PDE9A;PDE5A;PDE10A;PDE6C;PDE6G;PDE6H;PDE6A;PDE6B;PDE11A |
| 3,5-cyclic-nucleotide phosphodiesterase activity | PDE5A;PDE10A;PDE11A;PDE8A;PDE8B;PDE9A;PDE5AB;PDE3B;PDE6D |
| metal ion binding | ZNF358;ZNF791;ZNF239;FAHD2B;ZFP746;VDRA;BCL11B;ZNF488;ATP1A1B |
| protein binding | HIST1H4L;LSAMP;SRPK2;SCUBE3;TTC32;SMAD9;FBXO3;KLHL22;CHMP1A |
PDE9A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDE9A here. Most of them are supplied by our site. Hope this information will be useful for your research of PDE9A.
TRIM32; C9orf106; BAG3; LMO2; CLK1
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