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PEG10

  • Official Full Name

    paternally expressed 10

  • Overview

    This is a paternally expressed imprinted gene that encodes transcripts containing two overlapping open reading frames (ORFs), RF1 and RF1/RF2, as well as retroviral-like slippage and pseudoknot elements, which can induce a -1 nucleotide frame-shift. ORF1 encodes a shorter isoform with a CCHC-type zinc finger motif containing a sequence characteristic of gag proteins of most retroviruses and some retrotransposons. The longer isoform is the result of -1 translational frame-shifting leading to translation of a gag/pol-like protein combining RF1 and RF2. It contains the active-site consensus sequence of the protease domain of pol proteins. Additional isoforms resulting from alternatively spliced transcript variants, as well as from use of upstream non-AUG (CUG) start codon, have been reported for this gene. Increased expression of this gene is associated with hepatocellular carcinomas.
  • Synonyms

    PEG10; paternally expressed 10; retrotransposon-derived protein PEG10; HB 1; KIAA1051; Mar2; Mart2; MEF3L; RGAG3; MyEF 3; AA407948; Edr; Embryonal carcinoma differentiation regulated; Embryonal carcinoma differentiation-regulated protein; HB1; Mammalian retrotransposon-derived protein 2; MEF3 like 1; MEF3-like protein 1; MEF3L1; Myelin expression factor 3-like protein 1; Paternally expressed gene 10 ORF1; Paternally expressed gene 10 protein; PEG10 protein; PEG10_HUMAN; Putative uncharacterized protein PEG10; Retrotransposon gag domain containing 3; Retrotransposon gag domain-containing protein 3; Retrotransposon-derived gag-like polyprotein; Ty3/Gypsy-like protein; OTTHUMP00000208295; OTTHUMP00000208296; mamma; HB-1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PEG10-1640H Recombinant Human PEG10, GST-tagged E.coli GST 1-325aa
Human PEG10-3306HCL Recombinant Human PEG10 293 Cell Lysate HEK293 N/A
Human PEG10-3307HCL Recombinant Human PEG10 293 Cell Lysate HEK293 N/A
Human PEG10-21H Recombinant Human PEG10 protein, GST-tagged Wheat Germ GST 325
Human PEG10-3530H Recombinant Human PEG10 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PEG10-22H Recombinant Human PEG10 protein, Myc/DDK-tagged HEK293 Myc/DDK 325
Human PEG10-6840HF Recombinant Full Length Human PEG10 Protein, GST-tagged In Vitro Cell Free System GST 325 amino acids
Mouse PEG10-12624M Recombinant Mouse PEG10 Protein Mammalian Cell His
Mouse PEG10-6629M-B Recombinant Mouse PEG10 Protein Pre-coupled Magnetic Beads HEK293
Mouse PEG10-6629M Recombinant Mouse PEG10 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein

PEG10 involved in several pathways and played different roles in them. We selected most pathways PEG10 participated on our site, such as Validated targets of C-MYC transcriptional activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with PEG10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Validated targets of C-MYC transcriptional activationNDUFAF2;MTDH;SERPINI1;HUWE1;MYCT1;PRDX3;DDX18;IREB2;PEG10

PEG10 has several biochemical functions, for example, DNA binding, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PEG10 itself. We selected most functions PEG10 had, and list some proteins which have the same functions with PEG10. You can find most of the proteins on our site.

Function Related Protein
DNA bindingTAF11;SMARCC1B;MYCB;G3BP1;EXO1;ZIC4;ZFP583;AHRRA;VEPH1
poly(A) RNA bindingWDR46;TARDBP;SRSF7;DMGDH;RBM14;FAM103A1;SLC25A11;ZAK;RNPS1
protein bindingEEF1E1;MPP2;RHEBL1;ALS2CR11;TDRKH;CDKN2C;ARNTL1A;OOEP;GOLGA3
zinc ion bindingZNF92;BRF1A;FHL1;PRKCBB;RNF128A;ZDHHC13;PJA1;RNF187;ANPEPA

PEG10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PEG10 here. Most of them are supplied by our site. Hope this information will be useful for your research of PEG10.

FAM127A; LDOC1; CALCOCO2; FAM127C; SIAH1; TOLLIP; LAMTOR5; CLIP4; LNX2

  • Q&As
  • Reviews

Q&As (6)

Ask a question
What are the potential applications of PEG10 protein? 10/17/2023

PEG10 protein can be a candidate for drug development because of its role in regulating cell growth and differentiation. In addition, PEG10 protein can also be used to study the causes and mechanisms of liver disease.

How to detect the expression level of PEG10 protein? 05/22/2022

The expression level of PEG10 protein can be detected by immunohistochemistry, western blot or real-time quantitative PCR. These methods use specific antibodies to bind to the PEG10 protein, allowing qualitative and quantitative analysis of it.

What are the interactions between PEG10 and other proteins? 01/12/2022

This protein can interact with other proteins to regulate its function. For example, it may interact with proteins in transcription factors or other signal transduction pathways. By studying these interactions, we can further understand the mechanism of action of PEG10 protein.

Can the expression of PEG10 protein be regulated by gene knockout or knock-down technique? 02/03/2021

PEG10 protein can be regulated by using gene knockout or knock-down techniques. Gene knockout techniques reduce or eliminate the expression of a target gene by deleting it. Knock-down techniques inhibit the expression of target genes by using short hairpin RNA (shRNA) or small interfering RNA (siRNA). These techniques can be used to study the role of PEG10 protein in cell growth and differentiation.

What factors should be considered for drug development targeting PEG10 protein? 10/20/2020

Drug development targeting PEG10 requires consideration of a number of factors, including its specificity, safety, pharmacokinetic properties, and potential side effects. In addition, issues such as the dosage form, route of administration and design of clinical trials need to be considered. These factors will help ensure the success of drug development and the safety of patients.

Can the function of PEG10 protein be studied by means of structural biology? 07/03/2020

Structural biology approaches can help us understand the function of PEG10 protein. By analyzing the three-dimensional structure of PEG10 protein, we can understand the relationship between its shape and function. In addition, the conformation or function of PEG10 protein can also be changed by chemical biological methods, so as to study its mechanism of action.

Customer Reviews (3)

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Reviews
09/18/2022

    There will be no interaction with other drugs, and there will be no effects.

    09/09/2020

      It has good effect and stability in gene expression regulation.

      07/17/2020

        With PEG10, the efficiency of the experiment was significantly improved.

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