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Official Full Name phosphoribosylformylglycinamidine synthase
Background Purines are necessary for many cellular processes, including DNA replication, transcription, and energy metabolism. Ten enzymatic steps are required to synthesize inosine monophosphate (IMP) in the de novo pathway of purine biosynthesis. The enzyme encoded by this gene catalyzes the fourth step of IMP biosynthesis.
Synonyms PFAS; phosphoribosylformylglycinamidine synthase; FGAR amidotransferase; FGARAT; KIAA0361; PURL; FGAM synthase; formylglycinamide ribotide synthetase; formylglycinamide ribotide amidotransferase; FGAMS
    • Species :
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Tag :
    • His
    • SUMO
    • Myc
    • Myc/DDK
    • DDK
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PFAS-2335H Recombinant Human PFAS Protein (1064-1302 aa), His-SUMO-Myc-tagged E.coli His/SUMO/Myc
    Human PFAS-5088H Recombinant Human PFAS Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human PFAS-576H Recombinant Human PFAS Mammalian Cell His
    Human PFAS-919H Recombinant Human PFAS Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Mouse Pfas-4805M Recombinant Mouse Pfas Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Zebrafish PFAS-4224Z Recombinant Zebrafish PFAS Mammalian Cell His

    pfas involved in several pathways and played different roles in them. We selected most pathways pfas participated on our site, such as Purine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with pfas were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Purine metabolism POLR3GL; ENTPD4; ADKA; POLA1; PRPS2; PGM1; AMPD2; POLR1C; ENTPD1; CANT1A
    Metabolic pathways GULO; OXSM; AGXT2; CYP3A41B; MCEE; EBP; ACOT1; ASPA; DAO.3; HSD17B12A

    pfas has several biochemical functions, for example, ATP binding, metal ion binding, phosphoribosylformylglycinamidine synthase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by pfas itself. We selected most functions pfas had, and list some proteins which have the same functions with pfas. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding MCM4; ATAD3A; CASKB; UBE2G2; MYH13; CSNK2A2A; MKI67; CAMK2D1; DDX6; CHUK
    metal ion binding PRKCDA; CPS1; GTF2E1; NGB; ZNF83; NEK1; ASPHD2; RNF34B; DDHD2; ZNF484
    phosphoribosylformylglycinamidine synthase activity PFAS

    pfas has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with pfas here. Most of them are supplied by our site. Hope this information will be useful for your research of pfas.

    Webster, GM; Venners, SA; et al. Associations between Perfluoroalkyl acids (PFASs) and maternal thyroid hormones in early pregnancy: A population-based cohort study. ENVIRONMENTAL RESEARCH 133:338-347(2014).
    Granum, B; Haug, LS; et al. Pre-natal exposure to perfluoroalkyl substances may be associated with altered vaccine antibody levels and immune-related health outcomes in early childhood. JOURNAL OF IMMUNOTOXICOLOGY 10:373-379(2013).

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