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PTGDS

  • Official Full Name

    prostaglandin D2 synthase 21kDa (brain)

  • Overview

    Prostaglandin D synthase (PGDS) catalyzes the isomerization of PGH2 to produce PGD2. Lipocalin-type PGDS (L-PGDS, a.k.a.β-trace) is a homodimer with each subunit ranging in size from 20-31 kDa, depending on glycosylation. L-PGDS has two functions: it catalyzes the conversion of PGH2 to PGD2 and acts as a carrier protein for lipid-like molecules (i.e., retinoids and thyroid hormones). PGD2 is involved in sleep regulation, nociception, platelet aggregation, and allergic and inflammatory responses. There is also some evidence to indicate the involvement of PGD2 and its J-series metabolites in pregnancy and parturition.
  • Synonyms

    PTGDS; prostaglandin D2 synthase 21kDa (brain); prostaglandin D2 synthase (21kD, brain); prostaglandin-H2 D-isomerase; L PGDS; lipocalin type prostaglandin D synthase; PGDS; cerebrin-28; PGD2 synthase; beta-trace protein; prostaglandin D synthase; prostaglandin-D2 synthase; glutathione-independent PGD synthase; glutathione-independent PGD synthetase; lipocalin-type prostaglandin D synthase; lipocalin-type prostaglandin-D synthase; PDS; PGD2; LPGDS; PGDS2; L-PGDS;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • Mammalian Cell
  • Mammalian cells
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • SUMO
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PTGDS-2501H Recombinant Human Prostaglandin D2 Synthase 21kDa (brain), His-tagged E.coli His 23-190aa
Human PTGDS-316H Recombinant Human PTGDS Protein, His-tagged HEK293 His
Human PTGDS-8578H Recombinant Human PTGDS protein(Met1-Gln190), His-tagged HEK293 C-His Met1-Gln190
Human PTGDS-101H Recombinant Human Prostaglandin D2 Synthase 21kDa (Brain), His-tagged E.coli His
Human PTGDS-1029H Recombinant Human PTGDS, His-tagged E.coli His
Human PTGDS-1339HCL Recombinant Human PTGDS cell lysate Human Cell N/A
Human PTGDS-54H Recombinant Human PTGDS Protein, GST-tagged E.coli GST
Human PTGDS-993H Recombinant Human PTGDS Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PTGDS-3110H Recombinant Human PTGDS Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human PTGDS-5037H Recombinant Human PTGDS Protein (Ala23-Gln190), C-His tagged Mammalian cells C-His Ala23-Gln190
Human PTGDS-079H Recombinant Human PTGDS Protein, GST-tagged E. coli GST
Human PTGDS-3386H Recombinant Human PTGDS protein, His-SUMO-tagged E.coli His-SUMO 23-190aa
Human PTGDS-6061H Recombinant Human PTGDS Protein (Pro32-Gln190), N-His tagged E.coli N-His Pro32-Gln190
Mouse PTGDS-13635M Recombinant Mouse PTGDS Protein Mammalian Cell His
Mouse PTGDS-7252M Recombinant Mouse PTGDS Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse PTGDS-7252M-B Recombinant Mouse PTGDS Protein Pre-coupled Magnetic Beads HEK293
Mouse Ptgds-35M Recombinant Mouse Ptgds Protein, GST-tagged E.coli GST
Mouse PTGDS-860M Recombinant Mouse PTGDS Protein (Met1-Glu189), His-tagged HEK293 His Met1-Glu189
Mouse Ptgds-53M Recombinant Mouse Ptgds Protein, GST-tagged E.coli GST
Mouse Ptgds-5218M Recombinant Mouse Ptgds Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat PTGDS-4805R Recombinant Rat PTGDS Protein Mammalian Cell His
Rat PTGDS-965R Recombinant Rat PTGDS Protein (Met1-Glu189), His-tagged HEK293 His Met1-Glu189
Rat Ptgds-1997R Recombinant Rat Ptgds Protein, His-tagged E.coli N-His Gln25-Glu189
Rat Ptgds-115R Recombinant Rat Ptgds Protein, GST-tagged E. coli GST
Rat PTGDS-4464R-B Recombinant Rat PTGDS Protein Pre-coupled Magnetic Beads HEK293
Rat PTGDS-4464R Recombinant Rat PTGDS Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PTGDS-3687R Recombinant Rhesus monkey PTGDS Protein, His-tagged Mammalian Cell His
Rhesus Macaque PTGDS-3505R Recombinant Rhesus Macaque PTGDS Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PTGDS-3505R-B Recombinant Rhesus Macaque PTGDS Protein Pre-coupled Magnetic Beads HEK293
Chicken PTGDS-5832C Recombinant Chicken PTGDS Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PTGDS Related Research Area

PTGDS involved in several pathways and played different roles in them. We selected most pathways PTGDS participated on our site, such as Arachidonic acid metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTGDS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Arachidonic acid metabolismCBR1L;GGTLC1;EPHX2;ALOX5AP;CYP2P10;CYP4A11;ALOX15;PLB1;CYP4B1
Metabolic pathwaysLPCAT1;TDO2;CEL.1;PPAP2C;ASL2;NME2A;GCSH;MTHFS;SAT2

PTGDS has several biochemical functions, for example, fatty acid binding, prostaglandin-D synthase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTGDS itself. We selected most functions PTGDS had, and list some proteins which have the same functions with PTGDS. You can find most of the proteins on our site.

Function Related Protein
fatty acid bindingAlb;FABP1;CYP4A14;FABP1B.1;O3far1;FABP7B;FABP10A;PTGDS;LBFABP
prostaglandin-D synthase activityPTGDS;HPGDS
protein bindingKRT86;RBM14;CCNE2;CCDC70;FAM156A;RARA;ARHGEF38;ACTA1;PTPRD
retinoid bindingLCN5;CRABP2;RBP4L;RBP5;PTGDS;RBP1;RBP2;RBP3;CRABP1
transporter activitySCARB1;OSTB;TMEM184A;SYPB;SLC2A15B;SLC23A2;RBP7B;SEC14L3;Slc4a2

PTGDS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTGDS here. Most of them are supplied by our site. Hope this information will be useful for your research of PTGDS.

KRTAP10-7; CACNA1A; BCAT2; EGFR; AKT1; MLH1; ATXN1; q5ngw2_fratt; menE; q81z98_bacan; q4r4p0_macfa; CTSB

  • Q&As
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