PHC1

  • Official Full Name

    polyhomeotic homolog 1 (Drosophila)

  • Overview

    This gene is a homolog of the Drosophila polyhomeotic gene, which is a member of the Polycomb group of genes. The gene;product is a component of a multimeric protein complex that contains EDR2 and the vertebrate Polycomb protein BMH1.;The gene product, the EDR2 protein, and the Drosophila polyhomeotic protein share 2 highly conserved domains, named;homology domains I and II. These domains are involved in protein-protein interactions and may mediate;heterodimerization of the protein encoded by this gene and the EDR2 protein.

  • Synonyms

    PHC1;polyhomeotic homolog 1 (Drosophila);early development regulator 1 (homolog of polyhomeotic 1) , EDR1, polyhomeotic like 1 (Drosophila);polyhomeotic-like protein 1;HPH1;RAE28;Early development regulatory protein 1;EDR1 PH1;mPH1;PH1;OTTHUMP00000238481;OTTHUMP00000238482;OTTHUMP00000238483;polyhomeotic-like 1;early development regulator 1 (homolog of polyhomeotic 1);EDR1

Recombinant Proteins

  • Human
  • Zebrafish
  • Chicken
  • Rhesus macaque
  • E.coli
  • Mammalian Cells
  • HEK293
  • GST
  • His
  • Non
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
PHC1-1675H Recombinant Human PHC1, GST-tagged E.coli Human GST C-term-350aa
PHC1-11728Z Recombinant Zebrafish PHC1 Mammalian Cells Zebrafish His
PHC1-1396C Recombinant Chicken PHC1 Mammalian Cells Chicken His
PHC1-3402R Recombinant Rhesus monkey PHC1 Protein, His-tagged Mammalian Cells Rhesus macaque His
PHC1-3239HCL Recombinant Human PHC1 293 Cell Lysate HEK293 Human Non
PHC1-3220R Recombinant Rhesus Macaque PHC1 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
PHC1-3220R-B Recombinant Rhesus Macaque PHC1 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque

    Involved Pathway

    PHC1 involved in several pathways and played different roles in them. We selected most pathways PHC1 participated on our site, such as Cellular Senescence,Cellular responses to stress,Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with PHC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Post-translational protein modification ALG10B,RING1,SEC22C,SSPO,EID3,ARSK,NSMCE1,TRAPPC10,DPH5,ST6GALNAC2
    SUMOylation RNF2,NSMCE4A,NSMCE2,SMC6,CBX8,PHC2,PHC3,NSMCE1,RING1,SMC5
    Metabolism of proteins NAPAB,ADAMTSL1,TOMM40,TIMM8A,SEMG1,RING1,ATPBD4,EEF1G,ADAMTSL3,SLC34A2A
    SUMOylation of DNA damage response and repair proteins EID3,CBX8,SCMH1,PHC2,PHC3,SMC6,NSMCE2,SMC5,RNF2,NSMCE1
    SUMO E3 ligases SUMOylate target proteins NSMCE2,RNF2,PHC3,RING1,NSMCE4A,CBX8,SMC5,EID3,PHC2,SMC6
    Oxidative Stress Induced Senescence SCMH1,KDM6B,CBX6A,BMI1A,PHC2,EED,CBX8,RING1,CBX6,RNF2
    Cellular responses to stress CBX8B,SUZ12A,RB1CC1,PHC2,DNAJC7,HIST1H1D,WIPI1,CBX8,RAD50,HSPA12B
    Cellular Senescence CBX6A,CDKN2B,SCMH1,KAT5,BMI1B,HIST1H1D,AGO1,ACD,EHMT2,POT1A

    Protein Function

    PHC1 has several biochemical functions, for example, DNA binding,chromatin binding,zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PHC1 itself. We selected most functions PHC1 had, and list some proteins which have the same functions with PHC1. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding HIST1H2BB,ZNF597,H2AFX,ZNF781,TP53,ZFAND5B,FOXB1A,ZSCAN10,NEUROD6,MGMT
    chromatin binding ERCC6,BCL6,JARID2,PRDM13,JUN,RFX4,KDM5A,TRPS1,DNMT1,MEIS3
    zinc ion binding NR5A1A,CSRP1A,PTGR1,ING5A,ZYX,SEC24A,BFAR,ZMIZ2,NR2F6A,ZNFL1

    Interacting Protein

    PHC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PHC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PHC1.

    CBX4;BMI1;PCGF2;CBX8;q81y32_bacan;HSPA8;PPP1CA;UBE2I;y2173_bacan;aadK;PHC2;SFMBT1;CBX4;Bmi1;Cbx2

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