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PHC1

Official Full Name

polyhomeotic homolog 1 (Drosophila)
Overview

This gene is a homolog of the Drosophila polyhomeotic gene, which is a member of the Polycomb group of genes. The gene;product is a component of a multimeric protein complex that contains EDR2 and the vertebrate Polycomb protein BMH1.;The gene product, the EDR2 protein, and the Drosophila polyhomeotic protein share 2 highly conserved domains, named;homology domains I and II. These domains are involved in protein-protein interactions and may mediate;heterodimerization of the protein encoded by this gene and the EDR2 protein.
Synonyms

PHC1; polyhomeotic homolog 1 (Drosophila); early development regulator 1 (homolog of polyhomeotic 1) , EDR1, polyhomeotic like 1 (Drosophila); polyhomeotic-like protein 1; HPH1; RAE28; Early development regulatory protein 1; EDR1 PH1; mPH1; PH1; OTTHUMP00000238481; OTTHUMP00000238482; OTTHUMP00000238483; polyhomeotic-like 1; early development regulator 1 (homolog of polyhomeotic 1); EDR1;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Rhesus Macaque
Zebrafish

Source

E.coli
HEK293
Mammalian Cell

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	PHC1-1675H	Recombinant Human PHC1, GST-tagged	E.coli	GST	C-term-350aa	$319 / 25ug
Human	PHC1-3239HCL	Recombinant Human PHC1 293 Cell Lysate	HEK293	N/A		Inquiry
Rhesus Macaque	PHC1-3402R	Recombinant Rhesus monkey PHC1 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	PHC1-3220R-B	Recombinant Rhesus Macaque PHC1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rhesus Macaque	PHC1-3220R	Recombinant Rhesus Macaque PHC1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Zebrafish	PHC1-11728Z	Recombinant Zebrafish PHC1	Mammalian Cell	His		Inquiry
Chicken	PHC1-1396C	Recombinant Chicken PHC1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

PHC1 involved in several pathways and played different roles in them. We selected most pathways PHC1 participated on our site, such as Cellular Senescence, Cellular responses to stress, Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with PHC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Cellular Senescence	HIST1H1D;TNIK;POT1A;EED;HIST1H1A;HIST3H2BB;TERF2;HIST4H4;H3F3B.1
Cellular responses to stress	TINF2;PRDX3;DYNLL2B;MAPKAPK2B;MAP1LC3C;HMGA1B;ATG9A;NUP50;LAMTOR2
Metabolism of proteins	KLHDC3;SFTPC;NAPB;SEC16B;B3GNT3;IGFBP6A;FBXW2;LMCD1;GRPEL1
Oxidative Stress Induced Senescence	CBX8;RING1;TNIK;SUZ12A;KDM6B;CBX6A;EED;PHC3;CBX6
Post-translational protein modification	MCFD2;SMC5;SEC22A;TRAPPC10;TRAPPC2L;TRAPPC4;SEC22C;SPON2;TRAPPC2
SUMO E3 ligases SUMOylate target proteins	NSMCE2;NSMCE1;CBX4;CBX8;EID3;NSMCE4A;PHC1;SMC6;PHC3
SUMOylation	NSMCE4A;NSMCE1;SCMH1;PHC3;UBA2;SENP5;RING1;PHC2;NSMCE2
SUMOylation of DNA damage response and repair proteins	SCMH1;EID3;SMC5;PHC1;PHC3;RNF2;SMC6;NSMCE2;NSMCE1

PHC1 has several biochemical functions, for example, DNA binding, chromatin binding, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PHC1 itself. We selected most functions PHC1 had, and list some proteins which have the same functions with PHC1. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	ZFP93;NCOR2;SPI1A;HMX4;KLF9;FOXL1;NFIB;H1FX;ZNF670
chromatin binding	HMGA1;APTX;TLE4;ELK4;PAF1;HESX1;ISL1;REST;MCM5
zinc ion binding	GFI1AB;GFI1;PHRF1;SIVA1;KAT6B;SP140;TRIM101;PRKCB;ZACN

PHC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PHC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PHC1.

CBX4; BMI1; PCGF2; CBX8; q81y32_bacan; HSPA8; PPP1CA; UBE2I; y2173_bacan; aadK; PHC2; SFMBT1; CBX4; Bmi1; Cbx2