Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

PHC2

  • Official Full Name

    polyhomeotic homolog 2 (Drosophila)

  • Overview

    In Drosophila melanogaster, the Polycomb group (PcG) of genes are part of a cellular memory system that is responsible for the stable inheritance of gene activity. PcG proteins form a large multimeric, chromatin-associated protein complex. The protein encoded by this gene has homology to the Drosophila PcG protein polyhomeotic (Ph) and is known to heterodimerize with EDR1 and colocalize with BMI1 in interphase nuclei of human cells. The specific function in human cells has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Synonyms

    PHC2; polyhomeotic homolog 2 (Drosophila); PH2; EDR2; HPH2; polyhomeotic-like protein 2; polyhomeotic 2; polyhomeotic-like 2; early development regulatory protein 2; early development regulator 2 (homolog of polyhomeotic 2);
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PHC2-1676H Recombinant Human PHC2, GST-tagged E.coli GST C-term-323aa
Human PHC2-1342HCL Recombinant Human PHC2 cell lysate N/A
Mouse PHC2-12711M Recombinant Mouse PHC2 Protein Mammalian Cell His
Mouse PHC2-6679M-B Recombinant Mouse PHC2 Protein Pre-coupled Magnetic Beads HEK293
Mouse PHC2-6679M Recombinant Mouse PHC2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PHC2 Related Articles
  • PHC2 Related Research Area

PHC2 involved in several pathways and played different roles in them. We selected most pathways PHC2 participated on our site, such as Cellular Senescence, Cellular responses to stress, Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with PHC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cellular SenescenceCDKN2A;RBBP7;CBX8B;CABIN1;HIST4H4;CBX4;HIST1H1A;HMGA1-RS1;MINK1
Cellular responses to stressEP400;NUPL2;ATG9B;WDR45;PHC3;KDM6B;H3F3B.1;AMBRA1A;RB1CC1
Metabolism of proteinsOTOP2;ARSH;KDELR3;MFGE8;IGFBP5B;PFDN4;ADAMTS18;TGFBI;EXOSC8
Oxidative Stress Induced SenescenceRNF2;EED;RING1;CBX4;SUZ12B;MINK1;CBX8B;PHC2;PHC3
Post-translational protein modificationOTOP2;ARSK;NSMCE1;MPDU1B;ARSH;ADAMTSL3;DHPS;TRAPPC4;SCMH1
SUMO E3 ligases SUMOylate target proteinsCBX4;NSMCE2;SMC5;PHC1;SMC6;SCMH1;RNF2;RING1;CBX8
SUMOylationNSMCE1;RING1;EID3;SAE1;SCMH1;RNF2;NSMCE2;SENP1;SMC5
SUMOylation of DNA damage response and repair proteinsRNF2;SCMH1;NSMCE1;CBX8;PHC1;PHC3;NSMCE4A;NSMCE2;SMC5

PHC2 has several biochemical functions, for example, DNA binding, identical protein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PHC2 itself. We selected most functions PHC2 had, and list some proteins which have the same functions with PHC2. You can find most of the proteins on our site.

Function Related Protein
DNA bindingCEBPZ;ELMSAN1A;ZNF286A;LUC7L3;ZNF572;ZNF434;POLE4;HER6;ZNF354A
identical protein bindingPLK4;PLIN5;GRASP;KLHL7;SYP;SAFB2;DCP1A;ACADM;MRFAP1L1
protein bindingGTPBP3;TSC22D3;GATA5;KRTAP3-1;SLC52A2;MPP2;HELT;GDAP2;CCDC11
zinc ion bindingRARAA;ZFP598;MYT1;ZDHHC6;KNG1;BTR12;CECR1A;THRAA;DNAJC24

PHC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PHC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PHC2.

PCGF2; BMI1; SIAH1; CBX8

Isono, K; Fujimura, Y; et al. Mammalian polyhomeotic homologues Phc2 and Phc1 act in synergy to mediate polycomb repression of Hox genes. MOLECULAR AND CELLULAR BIOLOGY 25:6694-6706(2005).
  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (0)

Write a review

Ask a Question for All PHC2 Products

Required fields are marked with *

My Review for All PHC2 Products

Required fields are marked with *

logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /

Stay Updated on the Latest Bioscience Trends