phf2 Protein, PHD finger protein 2


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Official Full Name PHD finger protein 2
Background This gene encodes a protein which contains a zinc finger-like PHD (plant homeodomain) finger, distinct from other classes of zinc finger motifs, and a hydrophobic and highly conserved domain. The PHD finger shows the typical Cys4-His-Cys3 arrangement. PHD finger genes are thought to belong to a diverse group of transcriptional regulators possibly affecting eukaryotic gene expression by influencing chromatin structure.
Synonyms PHF2; PHD finger protein 2; lysine-specific demethylase PHF2; CENP 35; centromere protein 35; JHDM1E; jumonji C domain containing histone demethylase 1E; KIAA0662; jumonji C domain-containing histone demethylase 1E; GRC5; CENP-35; MGC176680
    • Species :
    • Mouse
    • Zebrafish
    • Source :
    • Mammalian Cell
    • Tag :
    • His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse PHF2-12724M Recombinant Mouse PHF2 Protein Mammalian Cell His
    Zebrafish PHF2-7956Z Recombinant Zebrafish PHF2 Mammalian Cell His

    phf2 involved in several pathways and played different roles in them. We selected most pathways phf2 participated on our site, such as Chromatin modifying enzymes, Chromatin organization, HDMs demethylate histones, which may be useful for your reference. Also, other proteins which involved in the same pathway with phf2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Chromatin modifying enzymes YEATS4; DNMT3A; PHF21A; CSRP2BP; SETD3; ING5A; GATAD2AB; KANSL3; MTA2; KAT7A
    Chromatin organization DMAP1; ARID2; SUZ12B; KAT8; MSL2B; ARID4A; USP22; ANO9A; PRMT6; SUZ12
    HDMs demethylate histones KDM5BB; KDM5D; KDM6AL; KDM2AA; KDM6B; PHF2; KDM2B; KDM3A; KDM5B; ARID5B

    phf2 has several biochemical functions, for example, 2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity, C-19 gibberellin 2-beta-dioxygenase activity, C-20 gibberellin 2-beta-dioxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by phf2 itself. We selected most functions phf2 had, and list some proteins which have the same functions with phf2. You can find most of the proteins on our site.

    Function Related Protein
    2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity JMJD1C; KDM5BB; KDM5D; PHF2
    C-19 gibberellin 2-beta-dioxygenase activity KDM5D; PHF2; KDM5BB; JMJD1C
    C-20 gibberellin 2-beta-dioxygenase activity PHF2; KDM5D; JMJD1C; KDM5BB
    DNA-N1-methyladenine dioxygenase activity JMJD1C; ALKBH3; ALKBH2; PHF2; FTO; KDM5BB; KDM5D
    dioxygenase activity ASPHD1; OGFOD3; BCO1; MINA; ALOX5A; ASPHD2; KDM5D; KDM4B; KDM3B; TDO2B
    histone demethylase activity (H3-K9 specific) PHF2; PHF8; KDM1A; KDM7AB; KDM4D; JHDM1D; KDM4C
    hypophosphite dioxygenase activity KDM5BB; KDM5D; JMJD1C; PHF2
    iron ion binding CYP17A1; CYP8B1; AOX4; CYP4X1; NFU1; CYP19A1B; HBAD; ALOX5A; CYP2C70; HBB
    metal ion binding ZNF37A; ZNF334; ADAM25; PAPL; PHLPP2; KLF9; ZFP689; ITGA7; ADARB2; MLL1
    methylated histone binding LRWD1; CAPNS2; ING5; CBX4; CHD1; TDRD3; MSH6; DPPA3; L3MBTL2; PHF1
    oxidoreductase activity CYP2X7; DHRS7CB; RSAD1; PYCR1A; CYP4F14; IMPDH1A; CYP2K18; RDH10B; GPX1B; ADH1
    procollagen-proline dioxygenase activity JMJD1C; KDM5D; PHF2; KDM5BB
    sulfonate dioxygenase activity KDM5BB; PHF2; JMJD1C; KDM5D
    contributes_to transcription coactivator activity ARID5B; CREBBP; PHF2; EP300
    zinc ion binding RBM14B; TRAIP; POLR3K; MYLIPB; WBP7; ADAM5; HRG; RNF38; FBXO30; ZNF212

    phf2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with phf2 here. Most of them are supplied by our site. Hope this information will be useful for your research of phf2.


    Shi, G; Wu, M; et al. PHD Finger Protein 2 (PHF2) Represses Ribosomal RNA Gene Transcription by Antagonizing PHF Finger Protein 8 (PHF8) and Recruiting Methyltransferase SUV39H1. JOURNAL OF BIOLOGICAL CHEMISTRY 289:29691-29700(2014).
    Lee, KH; Ju, UI; et al. The Histone Demethylase PHF2 Promotes Fat Cell Differentiation as an Epigenetic Activator of Both C/EBP alpha and C/EBP delta. MOLECULES AND CELLS 37:734-741(2014).

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