PHF2

  • Official Full Name

    PHD finger protein 2
  • Overview

    This gene encodes a protein which contains a zinc finger-like PHD (plant homeodomain) finger, distinct from other classes of zinc finger motifs, and a hydrophobic and highly conserved domain. The PHD finger shows the typical Cys4-His-Cys3 arrangement. PHD finger genes are thought to belong to a diverse group of transcriptional regulators possibly affecting eukaryotic gene expression by influencing chromatin structure.
  • Synonyms

    PHF2;PHD finger protein 2;lysine-specific demethylase PHF2;CENP 35;centromere protein 35;JHDM1E;jumonji C domain containing histone demethylase 1E;KIAA0662;jumonji C domain-containing histone demethylase 1E;GRC5;CENP-35;MGC176680
Cat.# Product name Source (Host) Species Tag Protein Length Price
PHF2-12724M Recombinant Mouse PHF2 Protein Mammalian Cells Mouse His
PHF2-7956Z Recombinant Zebrafish PHF2 Mammalian Cells Zebrafish His
PHF2-6689M Recombinant Mouse PHF2 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
PHF2-6689M-B Recombinant Mouse PHF2 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    PHF2 involved in several pathways and played different roles in them. We selected most pathways PHF2 participated on our site, such as Chromatin modifying enzymes,Chromatin organization,HDMs demethylate histones, which may be useful for your reference. Also, other proteins which involved in the same pathway with PHF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Chromatin modifying enzymes KDM2B,KDM4C,PAX3A,ANO9A,WDR77,MEAF6,KAT7,SAP18,DPY30,TADA2A
    HDMs demethylate histones KDM5B,KDM4D,JMJD6,ARID5B,KDM4A,KDM3A,KDM3B,KDM5C,KDM2AA,KDM5BB
    Chromatin organization PADI2,KDM5BB,ENY2,SMARCB1B,MBIP,KDM4C,ATF7IP,PRDM16,PADI6,PAX3A

    Protein Function

    PHF2 has several biochemical functions, for example, 2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity,C-19 gibberellin 2-beta-dioxygenase activity,C-20 gibberellin 2-beta-dioxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PHF2 itself. We selected most functions PHF2 had, and list some proteins which have the same functions with PHF2. You can find most of the proteins on our site.

    Function Related Protein
    metal ion binding MYO9B,JAZF1B,SORBS2,FOXP2,LNPA,ZFP131,FGD4A,HECTD1,TNNI3K,DDHD2
    2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity JMJD1C,KDM5BB,KDM5D
    contributes_to transcription coactivator activity EP300,ARID5B,CREBBP
    DNA-N1-methyladenine dioxygenase activity KDM5BB,FTO,KDM5D,ALKBH3,ALKBH2,JMJD1C
    C-20 gibberellin 2-beta-dioxygenase activity JMJD1C,KDM5BB,KDM5D
    oxidoreductase activity CYP2P10,CYP2V1,CYP2K22,CYP2X8,CYP2D6,ALDH9A1B,GMPR2,DHRS3A,TXNDC17,G6PDX
    iron ion binding CYP2E1,CYP2P6,CYP2F2,JMJD6,ALOX15,CYP2D10,CYP26B1,CYP1C2,CYP20A1,CYP2N13
    histone demethylase activity (H3-K9 specific) KDM4C,PHF8,KDM7AB,JHDM1D,KDM4D,KDM1A
    dioxygenase activity BCO2L,ADOB,ASPHD1,ADOA,ALOX5A,OGFOD3,KDM3B,PLOD1A,ALKBH6,HPDA

    Interacting Protein

    PHF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PHF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PHF2.

    Ywhae

    Resources

    References

    • Shi, G; Wu, M; et al. PHD Finger Protein 2 (PHF2) Represses Ribosomal RNA Gene Transcription by Antagonizing PHF Finger Protein 8 (PHF8) and Recruiting Methyltransferase SUV39H1. JOURNAL OF BIOLOGICAL CHEMISTRY 289:29691-29700(2014).
    • Lee, KH; Ju, UI; et al. The Histone Demethylase PHF2 Promotes Fat Cell Differentiation as an Epigenetic Activator of Both C/EBP alpha and C/EBP delta. MOLECULES AND CELLS 37:734-741(2014).

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