PHF2
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Official Full Name
PHD finger protein 2 -
Overview
This gene encodes a protein which contains a zinc finger-like PHD (plant homeodomain) finger, distinct from other classes of zinc finger motifs, and a hydrophobic and highly conserved domain. The PHD finger shows the typical Cys4-His-Cys3 arrangement. PHD finger genes are thought to belong to a diverse group of transcriptional regulators possibly affecting eukaryotic gene expression by influencing chromatin structure. -
Synonyms
PHF2;PHD finger protein 2;lysine-specific demethylase PHF2;CENP 35;centromere protein 35;JHDM1E;jumonji C domain containing histone demethylase 1E;KIAA0662;jumonji C domain-containing histone demethylase 1E;GRC5;CENP-35;MGC176680
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PHF2-12724M | Recombinant Mouse PHF2 Protein | Mammalian Cells | Mouse | His |
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| PHF2-7956Z | Recombinant Zebrafish PHF2 | Mammalian Cells | Zebrafish | His |
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| PHF2-6689M | Recombinant Mouse PHF2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| PHF2-6689M-B | Recombinant Mouse PHF2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
PHF2 involved in several pathways and played different roles in them. We selected most pathways PHF2 participated on our site, such as Chromatin modifying enzymes,Chromatin organization,HDMs demethylate histones, which may be useful for your reference. Also, other proteins which involved in the same pathway with PHF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chromatin organization | SAP130,SMARCC1,SMARCD3,ELP3,ING5,PHF17,SMARCB1A,MSL1A,KDM2A,MBIP |
| Chromatin modifying enzymes | CHD4,KDM5C,WDR77,SMARCE1,SMYD2,SUZ12,GATAD2AB,C20orf20,MBD3,AEBP2 |
| HDMs demethylate histones | KDM6AL,KDM3B,KDM3A,JHDM1D,KDM4D,KDM5C,PHF8,KDM5BA,KDM2A,KDM5A |
Protein Function
PHF2 has several biochemical functions, for example, 2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity,C-19 gibberellin 2-beta-dioxygenase activity,C-20 gibberellin 2-beta-dioxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PHF2 itself. We selected most functions PHF2 had, and list some proteins which have the same functions with PHF2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| histone demethylase activity (H3-K9 specific) | KDM4D,PHF8,JHDM1D,KDM1A,KDM7AB,KDM4C |
| metal ion binding | MBLAC1,ZNF785,NANOS1,SMAD1,TRIM26,GATA5,FOXP1,TERT,HBBE2,ABO |
| zinc ion binding | TRIM67,KCMF1,POLE,FHL2,BAZ2B,TRIM6,G2E3,DNPEP,PRKCA,CAR6 |
| oxidoreductase activity | GPD1C,GMPR2,SCD5,CRYM,LDHBB,CYP2X7,RTN4IP1,DHRS11A,MICAL2,PYCR1B |
| sulfonate dioxygenase activity | JMJD1C,KDM5D,KDM5BB |
| methylated histone binding | RBBP5,ING5,PHF1,LOXL2,MSH6,CBX5,ING3,PHF13,GLYR1,PHF8 |
| C-20 gibberellin 2-beta-dioxygenase activity | JMJD1C,KDM5D,KDM5BB |
| DNA-N1-methyladenine dioxygenase activity | JMJD1C,ALKBH3,FTO,KDM5BB,ALKBH2,KDM5D |
| C-19 gibberellin 2-beta-dioxygenase activity | KDM5D,JMJD1C,KDM5BB |
Interacting Protein
PHF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PHF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PHF2.
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References
- Shi, G; Wu, M; et al. PHD Finger Protein 2 (PHF2) Represses Ribosomal RNA Gene Transcription by Antagonizing PHF Finger Protein 8 (PHF8) and Recruiting Methyltransferase SUV39H1. JOURNAL OF BIOLOGICAL CHEMISTRY 289:29691-29700(2014).
- Lee, KH; Ju, UI; et al. The Histone Demethylase PHF2 Promotes Fat Cell Differentiation as an Epigenetic Activator of Both C/EBP alpha and C/EBP delta. MOLECULES AND CELLS 37:734-741(2014).
