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PKD1

  • Official Full Name

    polycystic kidney disease 1 (autosomal dominant)

  • Overview

    This gene encodes a member of the polycystin protein family. The encoded glycoprotein contains a large N-terminal extracellular region, multiple transmembrane domains and a cytoplasmic C-tail. It is an integral membrane protein that functions as a regulator of calcium permeable cation channels and intracellular calcium homoeostasis. It is also involved in cell-cell/matrix interactions and may modulate G-protein-coupled signal-transduction pathways. It plays a role in renal tubular development, and mutations in this gene cause autosomal dominant polycystic kidney disease type 1 (ADPKD1). ADPKD1 is characterized by the growth of fluid-filled cysts that replace normal renal tissue and result in end-stage renal failure. Splice variants encoding different isoforms have been noted for this gene. Also, six pseudogenes, closely linked in a known duplicated region on chromosome 16p, have been described.
  • Synonyms

    PKD1; polycystic kidney disease 1 (autosomal dominant); polycystin-1; PBP; Pc 1; polycystin 1; transient receptor potential cation channel; subfamily P; member 1; TRPP1; Autosomal dominant polycystic kidney disease 1 protein; Autosomal dominant polycystic kidney disease protein 1; OTTHUMP00000208669; OTTHUMP00000208670; Pc-1; PKD; PKD1_HUMAN; Polycystic Kidney Disease 1; polycystic kidney disease-associated protein; Polycystin 1 Precursor; transient receptor potential cation channel, subfamily P, member 1;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PKD1-4469H Recombinant Human PKD1 protein, His&His-tagged E.coli His&His 25-636aa
Human PKD1-4470H Recombinant Human PKD1 protein, His-tagged E.coli His 25-636aa
Mouse PKD1-12857M Recombinant Mouse PKD1 Protein Mammalian Cell His
Mouse PKD1-6777M Recombinant Mouse PKD1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse PKD1-6777M-B Recombinant Mouse PKD1 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PKD1 Related Articles

PKD1 involved in several pathways and played different roles in them. We selected most pathways PKD1 participated on our site, such as Assembly of the primary cilium, Cargo trafficking to the periciliary membrane, Organelle biogenesis and maintenance, which may be useful for your reference. Also, other proteins which involved in the same pathway with PKD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Assembly of the primary ciliumIFT88;KIF3C;TCTN3;CCDC41;CETN2;CKAP5;SSTR3;DCTN3;NPHP1
Cargo trafficking to the periciliary membraneUNC119B;EXOC1;RHOL;CNGA5;PKD2;TCP1;TTC8;RP2;LZTFL1
Organelle biogenesis and maintenanceIFT172;ARF4A;WDR19;TFB1M;DYNLRB1;TTC21B;IFT22;KIF3CB;IFT27
VxPx cargo-targeting to ciliumARF4;PKD2;CNGA2;ARF4A;RAB3IP;CNGA5;PKD1
XPodNet - protein-protein interactions in the podocyte expanded by STRINGCMIP;OASL2;O3far1;FRAS1;ZFP423;Siglece;ATP9A;Ighg;FLII

PKD1 has several biochemical functions, for example, calcium channel activity, carbohydrate binding, cation channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PKD1 itself. We selected most functions PKD1 had, and list some proteins which have the same functions with PKD1. You can find most of the proteins on our site.

Function Related Protein
calcium channel activityTRPM4;CACFD1;CACNA1DA;MCU;CACNA1SA;TRPM8;TRPC5;CACNG8A;SLC24A5
carbohydrate bindingCLEC2H;PKD1L3;FCN1;GALNT14;FCNA;KLRC4-KLRK1;LGALSLB;GALNT18A;GALNT10
cation channel activityPKD2L1;TRPC1;ASIC3;GAR1;FAM38A;PKD1;GRIN2A;GRIN3B;P2RX1
ion channel bindingTRAPPC2;TRPC1;BAK1;RNF207;CAV3;KCND3;SRI;CALM3;SRC
protein bindingBORA;CCL28;PPM1G;ZFYVE27;FNIP1;RAB11A;KATNBL1;BMF;DCD
protein domain specific bindingABCC2;YWHAE2;MYO7A;GABRR1;SNCA;YWHAB;CASP2;YWHAE1;CALM
protein kinase bindingTOM1L1;CDC25B;EMP2;PPP1CB;MAP3K1;TPRKB;PARP1;AKAP5;CCND2

PKD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PKD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PKD1.

SF1; Pkd2; Id2; ACTB; PDK2; Actb; CTTN

Lian, PW; Li, A; et al. Loss of Polycystin-1 Inhibits Bicc1 Expression during Mouse Development. PLOS ONE 9:-(2014).
Vijayakumar, S; Dang, S; et al. Aberrant expression of laminin-332 promotes cell proliferation and cyst growth in ARPKD. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 306:F640-F654(2014).
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