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PLAG1

Official Full Name

pleiomorphic adenoma gene 1
Overview

Pleomorphic adenoma gene 1 encodes a zinc finger protein with 2 putative nuclear localization signals. PLAG1, which is developmentally regulated, has been shown to be consistently rearranged in pleomorphic adenomas of the salivary glands. PLAG1 is activated by the reciprocal chromosomal translocations involving 8q12 in a subset of salivary gland pleomorphic adenomas. Three transcript variants encoding two different isoforms have been found for this gene.
Synonyms

PLAG1; pleiomorphic adenoma gene 1; zinc finger protein PLAG1; ZNF912; FGFR1/PLAG1 fusion variant 3; PLAG1_HUMAN; Pleiomorphic adenoma gene 1 protein; PSA; SGPA; OTTHUMP00000226422; OTTHUMP00000226423; OTTHUMP00000226424; COL1A2/PLAG1 fusion;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rat
Zebrafish

Source

E.coli
HEK293
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	PLAG1-1762H	Recombinant Human PLAG1, His-tagged	E.coli	His	151-500aa	$319 / 25ug
Human	PLAG1-31026TH	Recombinant Human PLAG1	Wheat Germ	N/A	98 amino acids	Inquiry
Human	PLAG1-3134HCL	Recombinant Human PLAG1 293 Cell Lysate	HEK293	N/A		Inquiry
Human	PLAG1-301522H	Recombinant Human PLAG1 protein, GST-tagged	E.coli	GST	Met1-Ser75	Inquiry
Human	PLAG1-2781H	Recombinant Human PLAG1 protein, His-tagged	E.coli	His	1-75 aa	$319 / 25ug
Mouse	PLAG1-12909M	Recombinant Mouse PLAG1 Protein	Mammalian Cell	His		Inquiry
Mouse	PLAG1-6810M	Recombinant Mouse PLAG1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	PLAG1-6810M-B	Recombinant Mouse PLAG1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	PLAG1-4493R	Recombinant Rat PLAG1 Protein	Mammalian Cell	His		Inquiry
Rat	PLAG1-4153R-B	Recombinant Rat PLAG1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	PLAG1-4153R	Recombinant Rat PLAG1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Zebrafish	PLAG1-3657Z	Recombinant Zebrafish PLAG1	Mammalian Cell	His		Inquiry
Chicken	PLAG1-3218C	Recombinant Chicken PLAG1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
PLAG1 Related Articles

PLAG1 involved in several pathways and played different roles in them. We selected most pathways PLAG1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PLAG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

PLAG1 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II transcription factor activity, sequence-specific DNA binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PLAG1 itself. We selected most functions PLAG1 had, and list some proteins which have the same functions with PLAG1. You can find most of the proteins on our site.

Function	Related Protein
RNA polymerase II core promoter proximal region sequence-specific DNA binding	PGR;NR2C1;STAT3;GZF1;ARNT2;JUND;GCFC2;GMEB1;NKX2-5
RNA polymerase II transcription factor activity, sequence-specific DNA binding	LYL1;GATA6;FEV;FOXE1;MITFA;SIM2;SPI1A;ELF5;SP3
metal ion binding	ZNF148;TP73;PFKL;ZFP804A;ZFP12;GALNTL2;NT5DC3;ZNF584;APEX1
transcription factor activity, sequence-specific DNA binding	HOXC6;MAFBB;ZNF445;NFYB;FOXJ1B;POU2F2;NR2F6B;ZKSCAN14;ZNF41
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	BCL11B;TFE3B;ELK3;MEF2A;CEBPG;EPAS1;TFAP2A;EBF3A;TP63

PLAG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLAG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PLAG1.

SMAD3; q8czt4_yerpe; ALB

Matsuyama, A; Hisaoka, M; et al. Aberrant PLAG1 expression in pleomorphic adenomas of the salivary gland: a molecular genetic and immunohistochemical study. VIRCHOWS ARCHIV 458:583-592(2011).

Uro-Coste, E; et al. 2009 update in salivary gland tumoral pathology. ANNALES DE PATHOLOGIE 29:274-285(2009).