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PLCH1

Official Full Name

phospholipase C, eta 1
Overview

PLCH1 is a member of the PLC-eta family of the phosphoinositide-specific phospholipase C (PLC) superfamily of enzymes;that cleave phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) to generate second messengers inositol;1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) (Hwang et al., 2005 (PubMed 15702972)).
Synonyms

PLCH1; phospholipase C, eta 1; phospholipase C like 3 , PLCL3; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase eta-1; DKFZp434C1372; KIAA1069; MGC117152; PLCeta1; PLC-L3; PLC eta 1; PLC-eta-1; phospholipase C-eta-1; phospholipase C-eta1a; phosph;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	PLCH1-1023H	Recombinant Human PLCH1 protein, His & T7-tagged	E.coli	His/T7	Met1~Ala237 (Accession # Q4KWH8)	Inquiry
Human	PLCH1-1766H	Recombinant Human PLCH1, GST-tagged	E.coli	GST	1273-1655aa	$319 / 25ug
Mouse	PLCH1-12926M	Recombinant Mouse PLCH1 Protein	Mammalian Cell	His		Inquiry
Mouse	PLCH1-6819M	Recombinant Mouse PLCH1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	PLCH1-6819M-B	Recombinant Mouse PLCH1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein
PLCH1 Related Articles

PLCH1 involved in several pathways and played different roles in them. We selected most pathways PLCH1 participated on our site, such as Inositol phosphate metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLCH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Inositol phosphate metabolism	MTMR8;PLCB1;PLCD1;MTMR4;MINPP1A;PLCE1;ITPK1A;PIK3C2B;MINPP1
Metabolic pathways	PPAP2A;GAD1B;PPT1;NAT;POLR3F;ACADM;TYR;GBA3;UCKL1

PLCH1 has several biochemical functions, for example, calcium ion binding, calcium-dependent phospholipase C activity, phosphatidylinositol phospholipase C activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PLCH1 itself. We selected most functions PLCH1 had, and list some proteins which have the same functions with PLCH1. You can find most of the proteins on our site.

Function	Related Protein
calcium ion binding	DHH;S100P;MMP30;CABP2;ATP2A1;NID2;SPATA21;ANXA8;TNNC1A
calcium-dependent phospholipase C activity
phosphatidylinositol phospholipase C activity	PLCD1A;CASR;PLCH1;PLCE1;CCR1;PLCG2;CCL5;PLCB4;PLCL2
signal transducer activity	EDNRAB;FAS;GPR149;GNAS;GNAIA;OLFR508;GNGT2A;VMN1R44;GPR21

PLCH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLCH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PLCH1.

EGFR

Saleh, SN; Albert, AP; et al. Activation of native TRPC1/C5/C6 channels by endothelin-1 is mediated by both PIP3 and PIP2 in rabbit coronary artery myocytes. JOURNAL OF PHYSIOLOGY-LONDON 587:5361-5375(2009).

Peppiatt-Wildman, CM; Albert, AP; et al. Endothelin-1 activates a Ca2+-permeable cation channel with TRPC3 and TRPC7 properties in rabbit coronary artery myocytes. JOURNAL OF PHYSIOLOGY-LONDON 580:755-764(2007).