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PLEKHB1

Official Full Name

pleckstrin homology domain containing, family B (evectins) member 1
Overview

This gene encodes a pleckstrin homology domain-containing adapter protein. The encoded protein is localized to the plasma membrane where it specifically binds phosphatidylinositol 3,4-bisphosphate. This protein may be involved in the formation of signaling complexes in the plasma membrane. Polymorphisms in this gene are associated with age-related macular degeneration. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 5.
Synonyms

PLEKHB1; pleckstrin homology domain containing, family B (evectins) member 1; KPL1; PHR1; PHRET1;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rat

Source

E.coli
HEK293
HEK293T
Mammalian Cell

Tag

GST
His
His (Fc)
Avi
Myc
DDK
Myc|DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	PLEKHB1-1780H	Recombinant Human PLEKHB1, GST-tagged	E.coli	GST	17-189	$319 / 25ug
Human	PLEKHB1-485HCL	Recombinant Human PLEKHB1 lysate	HEK293	N/A		Inquiry
Human	PLEKHB1-2105H	Recombinant Human PLEKHB1 Protein, MYC/DDK-tagged	HEK293	Myc/DDK		Inquiry
Mouse	PLEKHB1-12949M	Recombinant Mouse PLEKHB1 Protein	Mammalian Cell	His		Inquiry
Mouse	Plekhb1-4927M	Recombinant Mouse Plekhb1 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Mouse	PLEKHB1-6831M-B	Recombinant Mouse PLEKHB1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	PLEKHB1-6831M	Recombinant Mouse PLEKHB1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	PLEKHB1-4515R	Recombinant Rat PLEKHB1 Protein	Mammalian Cell	His		Inquiry
Rat	PLEKHB1-4175R	Recombinant Rat PLEKHB1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	PLEKHB1-4175R-B	Recombinant Rat PLEKHB1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Chicken	PLEKHB1-1920C	Recombinant Chicken PLEKHB1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

PLEKHB1 involved in several pathways and played different roles in them. We selected most pathways PLEKHB1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PLEKHB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

PLEKHB1 has several biochemical functions, for example, protein C-terminus binding, protein binding, protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PLEKHB1 itself. We selected most functions PLEKHB1 had, and list some proteins which have the same functions with PLEKHB1. You can find most of the proteins on our site.

Function	Related Protein
protein C-terminus binding	PXK;LIG4;CD2AP;VTA1;KPNA3;SIAH1A;KCNJ11;TAX1BP3;RAD51
protein binding	C4BPB;FAM72A;TEAD4;TREX1;TRIM43;ZC3H18;NAT2;PTGES2;FSTL5
protein homodimerization activity	FLT3LG;PCYT1A;DMRT2A;AOC3;SLC22A1;MYO7A;GSTM3;BAXB;PON1
signal transducer activity	ASZ1;OLFCG1;TMTOPSA;PPM1A;PTK2BB;OPN1MW4;CXCR4B;TAS2R123;TAAR12F

PLEKHB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLEKHB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PLEKHB1.

RAP1GDS1; ATXN1