PLK4
-
Official Full Name
polo-like kinase 4
-
Overview
This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. Three alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jun 2010] -
Synonyms
PLK4; polo-like kinase 4; SAK; STK18; serine/threonine-protein kinase PLK4; PLK-4; Snk akin kinase; serine/threonine kinase 18; serine/threonine-protein kinase 18; serine/threonine protein kinase SAK; serine/threonine-protein kinase Sak;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- Insect Cell
- Mammalian Cell
- Sf9 Insect Cell
- GST
- His
- His (Fc)
- Avi
- N/A
- N
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
PLK4 involved in several pathways and played different roles in them. We selected most pathways PLK4 participated on our site, such as Anchoring of the basal body to the plasma membrane, Assembly of the primary cilium, Cell Cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLK4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Anchoring of the basal body to the plasma membrane | TSGA14;MAPRE1A;SCLT1;CCDC123;ODF2;MARK4;CEP135;MAPRE1;CP110 |
| Assembly of the primary cilium | NPHP3;SSNA1;TTBK2;TRAF3IP1;BBS13;ARL3;CCP110;RHOL;SCLT1 |
| Cell Cycle | RBL2;PRKDC;PIANP;CHEK1;MCM9;USO1;NUPL2;CDKN2C;PANE1 |
| Cell Cycle, Mitotic | PANE1;BLZF1;MLF1IP;GORASP1;NUDC;CSNK2B;TUBGCP4;CKAP5;NUP50 |
| Centrosome maturation | NUMA1;DCTN1;CEP72;HAUS2;CEP76;NINL;TUBGCP5;DCTN2;CETN2 |
| FoxO signaling pathway | NLK1;GRM1;BRAF;RBL2;EP300;CAT;PTENB;NLK;INSB |
| G2/M Transition | NDE1;NINL;CEP78;CENPJ;CEP72;LIN9;MYBL2;CEP135;DCTN3 |
| Loss of Nlp from mitotic centrosomes | CEP70;MAPRE1B;CKAP5;MAPRE1A;MAPRE1;NEDD1;CEP72;CEP290;CP110 |
PLK4 has several biochemical functions, for example, ATP binding, identical protein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PLK4 itself. We selected most functions PLK4 had, and list some proteins which have the same functions with PLK4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | GLUL;TCP1;CDK10;DQX1;HSPA12B;DDX58;GUCY2F;SIK3;PANK1B |
| identical protein binding | GRB2;SMN2;MAP1S;NISCH;GNPNAT1;KHDC1B;IFIT3;DPY30;DHX8 |
| protein binding | FAM156A;MRPL12;LCORL;NFE2L2;TLDC2;ABCG8;NHP2;AGRN;HOMER2 |
| protein serine/threonine kinase activity | CAMK1DA;CDK11A;NIM1;DAPK1;TTN;PAK6;RIOK2;ZAK;PASK |
PLK4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLK4 here. Most of them are supplied by our site. Hope this information will be useful for your research of PLK4.
ARR3; TCEB3; C1orf109; SFN; CENPJ; xmd8-92; TAX1BP3; CHD3; MTUS2; FAM46C; czc8004
- Q&As
- Reviews
Q&As (6)
Ask a questionThere is an interaction between PLK4 protein and other proteins. For example, it interacts with certain proteins on spindle fibers to regulate chromosome segregation, and with other proteins in signal transduction pathways to regulate cell proliferation and differentiation.
PLK4 protein is mainly responsible for regulating the process of chromosome segregation and cytoplasmic division in cell division. It is associated with the assembly and function of spindle fibers, affecting the accuracy of chromosome segregation and cell division.
Certain biomolecules can be used as molecular markers of PLK4 protein, such as mRNA or protein of PLK4 protein detected in biological samples such as blood and urine. These markers can be used for early diagnosis of disease, prognostic judgment, or monitoring of treatment efficacy.
Therapeutics targeting the PLK4 protein are still in the early stages of research. A number of small molecule inhibitors and antibody drugs have been developed and initially evaluated in laboratories and clinical trials. However, further research and clinical validation of these treatments are needed to determine their safety and efficacy.
Therapeutic strategies for PLK4 protein include inhibition of its activity, regulation of its expression, and gene therapy. For example, the development of small molecule inhibitors or antibody drugs against the PLK4 protein to inhibit its aberrant activity in tumors, or the regulation of PLK4 protein expression through gene knockout or overexpression techniques.
Studies have shown that the abnormal expression of PLK4 protein is associated with the occurrence of a variety of tumors, including but not limited to brain cancer, lung cancer, breast cancer, pancreatic cancer, etc. It may be related to aspects such as proliferation, metastasis, and drug resistance of tumor cells.
Customer Reviews (3)
Write a reviewWith PLK4, the sensitivity of the experiment was significantly improved.
Strong anti-pollution ability, not easy to pollute, to ensure the accuracy of the experiment.
The method is very simple, and it is easy to obtain accurate experimental results.
Ask a Question for All PLK4 Products
Required fields are marked with *
My Review for All PLK4 Products
Required fields are marked with *
