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PLK4

  • Official Full Name

    polo-like kinase 4

  • Overview

    This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. Three alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
  • Synonyms

    PLK4; polo-like kinase 4; SAK; STK18; serine/threonine-protein kinase PLK4; PLK-4; Snk akin kinase; serine/threonine kinase 18; serine/threonine-protein kinase 18; serine/threonine protein kinase SAK; serine/threonine-protein kinase Sak;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • Insect Cell
  • Mammalian Cell
  • Sf9 Insect Cell
  • C
  • His
  • GST
  • Fc
  • Avi
  • Non
  • N
  • Twin strep
  • Flag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PLK4-705H Recombinant Human Polo-like Kinase 4, GST-His Sf9 Insect Cell GST M1-H970
Human PLK4-1789H Recombinant Human PLK4, GST-tagged E.coli GST 1-263aa
Human PLK4-3102HCL Recombinant Human PLK4 293 Cell Lysate HEK293 Non
Human PLK4-01H Recombinant Human PLK4 (G95L) Protein, GST-tagged Insect Cell GST 1-836
Human PLK4-39H Recombinant Active Human PLK4 (G95L) Mutant Protein, GST-tagged Insect Cell GST 1-836
Human PLK4-2618H Recombinant Human PLK4 protein, His-tagged E.coli His 1-263 aa
Human PLK4-1167H Recombinant Human PLK4 Protein (G581-G808), His tagged E.coli His G581-G808
Human PLK4-1166H Recombinant Human PLK4 Protein (G581-G808), Tag Free E.coli Non G581-G808
Human PLK4-103H Recombinant Human polo-like kinase 4 Protein, His&Flag&StrepII tagged E. coli N-Twin strep and C-His&Flag 581-812aa
Human PLK428748H Recombinant Human PLK4 (1-271) (T170D) Protein
Human PLK41217H Recombinant Human PLK4 (1-271) Protein
Human PLK49452H Recombinant Human PLK4 (6-271), T170D Protein
Human PLK4-3926H Recombinant Human PLK4 Protein (Met1-Pro263), N-His tagged E.coli His Met1-Pro263
Human PLK4-203H Recombinant Human polo-like kinase 4 Protein, His tagged E. coli C-His 581-812aa
Mouse PLK4-12980M Recombinant Mouse PLK4 Protein Mammalian Cell His
Mouse PLK4-6854M Recombinant Mouse PLK4 Protein, His (Fc)-Avi-tagged HEK293 His&Fc&Avi
Mouse PLK4-6854M-B Recombinant Mouse PLK4 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish PLK4-6558Z Recombinant Zebrafish PLK4 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

PLK4 involved in several pathways and played different roles in them. We selected most pathways PLK4 participated on our site, such as Anchoring of the basal body to the plasma membrane, Assembly of the primary cilium, Cell Cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLK4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Anchoring of the basal body to the plasma membraneCEP72;RAB3IP;CLASP1A;B9D1;DCTN1A;AKAP9;SCLT1;TMEM216;PLK4
Assembly of the primary ciliumKIFAP3;CSNK1E;DYNLRB1;IFT74;DYNLRB2;UNC119B;HDAC6;BBS2;IFT172
Cell CycleBORA;CDK11B;YWHAG;CDKN2B;YWHAZ;SMARCA5;ORC1L;SKP2;NEK2
Cell Cycle, MitoticCENPE;KIF2B;MYCA;CDT1;ENSAA;SETA;NCAPD2;PDS5A;CP110
Centrosome maturationMAPRE1;CEP290;TUBG1;CDK11B;CEP78;DCTN2;OFD1;SSNA1;CEP135
FoxO signaling pathwayTGFB3;BNIP3;GADD45AB;SIRT1;AKT1;STK11;HRASB;NLK1;FOXO4
G2/M TransitionCEP63;NINL;DCTN1A;NUMA1;MAPRE1;NDE1;SSNA1;TSGA14;BORA
Loss of Nlp from mitotic centrosomesCEP290;CEP152;CCP110;CEP72;DCTN1A;SDCCAG8;CKAP5;MAPRE1B;CEP63

PLK4 has several biochemical functions, for example, ATP binding, identical protein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PLK4 itself. We selected most functions PLK4 had, and list some proteins which have the same functions with PLK4. You can find most of the proteins on our site.

Function Related Protein
ATP bindingDAPK1;TESK1;MAP2K2A;DHX16;KLHL8;HSP70L;ERBB2;SYK;NME7
identical protein bindingSTAT2;TRIM21;PCBD1;SAFB2;VIL1;AMELX;CALCA;CTSC;MUL1A
protein bindingC17orf81;CCL4;THAP8;KCNE2;ELK4;PEX1;COMTD1;RAB6A;B9D2
protein serine/threonine kinase activityCHEK2;MAP2K4;DAPK3;PDK3;RPS6KA3;MKNK1;CHEK1;HUNK;TSSK3

PLK4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLK4 here. Most of them are supplied by our site. Hope this information will be useful for your research of PLK4.

ARR3; TCEB3; C1orf109; SFN; CENPJ; xmd8-92; TAX1BP3; CHD3; MTUS2; FAM46C; czc8004

  • Reviews
  • Q&As

Customer Reviews (3)

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Reviews
06/17/2023

    With PLK4, the sensitivity of the experiment was significantly improved.

    04/08/2022

      Strong anti-pollution ability, not easy to pollute, to ensure the accuracy of the experiment.

      11/07/2020

        The method is very simple, and it is easy to obtain accurate experimental results.

        Q&As (6)

        Ask a question
        Is the interaction between PLK4 protein and other proteins? 05/21/2023

        There is an interaction between PLK4 protein and other proteins. For example, it interacts with certain proteins on spindle fibers to regulate chromosome segregation, and with other proteins in signal transduction pathways to regulate cell proliferation and differentiation.

        What is the function of PLK4 protein in cell division? 12/04/2020

        PLK4 protein is mainly responsible for regulating the process of chromosome segregation and cytoplasmic division in cell division. It is associated with the assembly and function of spindle fibers, affecting the accuracy of chromosome segregation and cell division.

        Which biological molecules can be used as molecular markers of PLK4 protein? 11/30/2020

        Certain biomolecules can be used as molecular markers of PLK4 protein, such as mRNA or protein of PLK4 protein detected in biological samples such as blood and urine. These markers can be used for early diagnosis of disease, prognostic judgment, or monitoring of treatment efficacy.

        What is the current stage of research for the treatment of PLK4 protein? 08/11/2020

        Therapeutics targeting the PLK4 protein are still in the early stages of research. A number of small molecule inhibitors and antibody drugs have been developed and initially evaluated in laboratories and clinical trials. However, further research and clinical validation of these treatments are needed to determine their safety and efficacy.

        What are the therapeutic strategies for PLK4 protein? 08/04/2020

        Therapeutic strategies for PLK4 protein include inhibition of its activity, regulation of its expression, and gene therapy. For example, the development of small molecule inhibitors or antibody drugs against the PLK4 protein to inhibit its aberrant activity in tumors, or the regulation of PLK4 protein expression through gene knockout or overexpression techniques.

        Does abnormal PLK4 protein expression cause disease? 06/07/2020

        Studies have shown that the abnormal expression of PLK4 protein is associated with the occurrence of a variety of tumors, including but not limited to brain cancer, lung cancer, breast cancer, pancreatic cancer, etc. It may be related to aspects such as proliferation, metastasis, and drug resistance of tumor cells.

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