Recombinant Human PLK4 Protein (G581-G808), His tagged
Cat.No. : | PLK4-1167H |
Product Overview : | Recombinant Human 6His-TEV-PLK4(G581-G808) Protein was expressed in E. coli. |
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Description : | Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2. Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification. Phosphorylates CEP131 at 'Ser-78' and PCM1 at 'Ser-372' which is essential for proper organization and integrity of centriolar satellites. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Liquid |
Protein length : | G581-G808 |
Endotoxin : | < 0.01 EU per μg of the protein |
Purity : | 90% |
Stability : | Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade. |
Storage : | Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Storage Buffer : | Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol |
Shipping : | It is shipped out with blue ice. |
Gene Name : | PLK4 polo-like kinase 4 [ Homo sapiens (human) ] |
Official Symbol : | PLK4 |
Synonyms : | PLK4; polo-like kinase 4; polo like kinase 4 (Drosophila), serine/threonine kinase 18, STK18; serine/threonine-protein kinase PLK4; Sak; PLK-4; Snk akin kinase; serine/threonine kinase 18; serine/threonine-protein kinase 18; serine/threonine protein kinase SAK; serine/threonine-protein kinase Sak; SAK; STK18; |
Gene ID : | 10733 |
mRNA Refseq : | NM_001190799 |
Protein Refseq : | NP_001177728 |
MIM : | 605031 |
UniProt ID : | O00444 |
Products Types
◆ Recombinant Protein | ||
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PLK4-6854M | Recombinant Mouse PLK4 Protein, His (Fc)-Avi-tagged | +Inquiry |
PLK4-1166H | Recombinant Human PLK4 Protein (G581-G808), Tag Free | +Inquiry |
PLK41217H | Recombinant Human PLK4 (1-271) Protein | +Inquiry |
◆ Lysates | ||
PLK4-3102HCL | Recombinant Human PLK4 293 Cell Lysate | +Inquiry |
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Customer Reviews (3)
Write a reviewWith PLK4, the sensitivity of the experiment was significantly improved.
Strong anti-pollution ability, not easy to pollute, to ensure the accuracy of the experiment.
The method is very simple, and it is easy to obtain accurate experimental results.
Q&As (6)
Ask a questionThere is an interaction between PLK4 protein and other proteins. For example, it interacts with certain proteins on spindle fibers to regulate chromosome segregation, and with other proteins in signal transduction pathways to regulate cell proliferation and differentiation.
PLK4 protein is mainly responsible for regulating the process of chromosome segregation and cytoplasmic division in cell division. It is associated with the assembly and function of spindle fibers, affecting the accuracy of chromosome segregation and cell division.
Certain biomolecules can be used as molecular markers of PLK4 protein, such as mRNA or protein of PLK4 protein detected in biological samples such as blood and urine. These markers can be used for early diagnosis of disease, prognostic judgment, or monitoring of treatment efficacy.
Therapeutics targeting the PLK4 protein are still in the early stages of research. A number of small molecule inhibitors and antibody drugs have been developed and initially evaluated in laboratories and clinical trials. However, further research and clinical validation of these treatments are needed to determine their safety and efficacy.
Therapeutic strategies for PLK4 protein include inhibition of its activity, regulation of its expression, and gene therapy. For example, the development of small molecule inhibitors or antibody drugs against the PLK4 protein to inhibit its aberrant activity in tumors, or the regulation of PLK4 protein expression through gene knockout or overexpression techniques.
Studies have shown that the abnormal expression of PLK4 protein is associated with the occurrence of a variety of tumors, including but not limited to brain cancer, lung cancer, breast cancer, pancreatic cancer, etc. It may be related to aspects such as proliferation, metastasis, and drug resistance of tumor cells.
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