Recombinant Active Human PLK4 (G95L) Mutant Protein, GST-tagged
Cat.No. : | PLK4-39H |
Product Overview : | Recombinant human PLK4 (G95L) (1-836) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
- Specification
- Gene Information
- Related Products
- Download
Description : | This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. Three alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. |
Source : | Insect cell |
Species : | Human |
Tag : | GST |
Molecular Mass : | Approx 120 kDa |
Protein length : | 1-836 |
Purity : | > 90% |
Stability : | One year at -70 centigrade from data of shipment. |
Storage : | Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Concentration : | 0.05 μg/μL |
Storage Buffer : | Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 25% glycerol. |
Shipping : | Dry ice |
Gene Name : | PLK4 polo like kinase 4 [ Homo sapiens (human) ] |
Official Symbol : | PLK4 |
Synonyms : | PLK4; polo like kinase 4; SAK; STK18; MCCRP2; serine/threonine-protein kinase PLK4; Snk akin kinase; serine/threonine-protein kinase 18; serine/threonine-protein kinase Sak; EC 2.7.11.21 |
Gene ID : | 10733 |
mRNA Refseq : | NM_014264 |
Protein Refseq : | NP_055079 |
MIM : | 605031 |
UniProt ID : | O00444 |
Products Types
◆ Recombinant Protein | ||
PLK4-1166H | Recombinant Human PLK4 Protein (G581-G808), Tag Free | +Inquiry |
PLK4-01H | Recombinant Human PLK4 (G95L) Protein, GST-tagged | +Inquiry |
PLK4-1167H | Recombinant Human PLK4 Protein (G581-G808), His tagged | +Inquiry |
PLK4-6854M | Recombinant Mouse PLK4 Protein, His (Fc)-Avi-tagged | +Inquiry |
PLK41217H | Recombinant Human PLK4 (1-271) Protein | +Inquiry |
◆ Lysates | ||
PLK4-3102HCL | Recombinant Human PLK4 293 Cell Lysate | +Inquiry |
Related Gene
Not For Human Consumption!
Inquiry
- Reviews
- Q&As
Customer Reviews (3)
Write a reviewWith PLK4, the sensitivity of the experiment was significantly improved.
Strong anti-pollution ability, not easy to pollute, to ensure the accuracy of the experiment.
The method is very simple, and it is easy to obtain accurate experimental results.
Q&As (6)
Ask a questionThere is an interaction between PLK4 protein and other proteins. For example, it interacts with certain proteins on spindle fibers to regulate chromosome segregation, and with other proteins in signal transduction pathways to regulate cell proliferation and differentiation.
PLK4 protein is mainly responsible for regulating the process of chromosome segregation and cytoplasmic division in cell division. It is associated with the assembly and function of spindle fibers, affecting the accuracy of chromosome segregation and cell division.
Certain biomolecules can be used as molecular markers of PLK4 protein, such as mRNA or protein of PLK4 protein detected in biological samples such as blood and urine. These markers can be used for early diagnosis of disease, prognostic judgment, or monitoring of treatment efficacy.
Therapeutics targeting the PLK4 protein are still in the early stages of research. A number of small molecule inhibitors and antibody drugs have been developed and initially evaluated in laboratories and clinical trials. However, further research and clinical validation of these treatments are needed to determine their safety and efficacy.
Therapeutic strategies for PLK4 protein include inhibition of its activity, regulation of its expression, and gene therapy. For example, the development of small molecule inhibitors or antibody drugs against the PLK4 protein to inhibit its aberrant activity in tumors, or the regulation of PLK4 protein expression through gene knockout or overexpression techniques.
Studies have shown that the abnormal expression of PLK4 protein is associated with the occurrence of a variety of tumors, including but not limited to brain cancer, lung cancer, breast cancer, pancreatic cancer, etc. It may be related to aspects such as proliferation, metastasis, and drug resistance of tumor cells.
Ask a Question for All PLK4 Products
Required fields are marked with *
My Review for All PLK4 Products
Required fields are marked with *
Inquiry Basket