PLOD2

  • Official Full Name

    procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2

  • Overview

    The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of this gene are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.
  • Synonyms

    PLOD2; procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2; procollagen lysine, 2 oxoglutarate 5 dioxygenase (lysine hydroxylase) 2; procollagen-lysine,2-oxoglutarate 5-dioxygenase 2; LH2; lysyl hydroxlase 2; 2-oxoglutarate 5-dioxygenase 2; Lysine hydroxylase 2; Lysyl hydroxylase 2; OTTHUMP00000215204; OTTHUMP00000215205; OTTHUMP00000215206; PLOD 2; PLOD2_HUMAN; Procollagen lysine 2 oxoglutarate 5 dioxygenase 2; Procollagen-lysine; Telopeptide lysyl hydroxylase; TLH;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • Myc
  • His|T7
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PLOD2-31030TH Recombinant Human PLOD2 Wheat Germ N/A 732 amino acids
Human PLOD2-1181H Recombinant Human PLOD2 protein, His & T7-tagged E.coli His/T7 Lys644~Pro737 (Accession # O00469)
Human PLOD2-1793H Recombinant Human PLOD2, GST-tagged E.coli GST 459-540aa
Human PLOD2-3100HCL Recombinant Human PLOD2 293 Cell Lysate HEK293 N/A
Human PLOD2-35H Recombinant Human PLOD2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Human PLOD2-657H Recombinant Human PLOD2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PLOD2-377HF Recombinant Full Length Human PLOD2 Protein In Vitro Cell Free System 732 amino acids
Mouse Plod2-4939M Recombinant Mouse Plod2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Plod2-2343M Recombinant Mouse Plod2 protein, His-Myc-tagged Insect Cell His/Myc 26-737aa
Mouse Plod2-4907M Recombinant Mouse Plod2 protein, His-Myc-tagged E.coli His/Myc 26-737aa
Zebrafish PLOD2-5573Z Recombinant Zebrafish PLOD2 Mammalian Cell His
Zebrafish PLOD2-1763Z Recombinant Zebrafish PLOD2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

PLOD2 involved in several pathways and played different roles in them. We selected most pathways PLOD2 participated on our site, such as Lysine degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLOD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Lysine degradationPLOD1A;SUV39H2;PIPOX;GCDHB;HADHAA;ALDH9A1;C2orf34;TMLHE;ACAT2

PLOD2 has several biochemical functions, for example, L-ascorbic acid binding, iron ion binding, procollagen-lysine 5-dioxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PLOD2 itself. We selected most functions PLOD2 had, and list some proteins which have the same functions with PLOD2. You can find most of the proteins on our site.

Function Related Protein
L-ascorbic acid bindingOGFOD3;EGLN3;EGLN1B;P4HTM;OGFOD1;P3H2;OGFOD2;EGLN1;PHYH
iron ion bindingCYP3A25;CYP1A1;ALOX12;HBAA1;CYP2C55;LEPREL1;PLOD1A;P4HA1;CYP2C18
procollagen-lysine 5-dioxygenase activityPLOD2;FAM125B;PLOD1A;PLOD1;PLOD3

PLOD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLOD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PLOD2.

Fam107b; RUVBL2; MYC; cona_canen; Anxa2; HNRNPH2; q76353_9hiv1; ATG5; ITGB1BP2

Research Area

Related articles

Valverde-Franco, G; Hum, D; et al. The in Vivo Effect of Prophylactic Subchondral Bone Protection of Osteoarthritic Synovial Membrane in Bone-Specific Ephb4-Overexpressing Mice. AMERICAN JOURNAL OF PATHOLOGY 185:335-346(2015).
Monthoux, C; de Brot, S; et al. Skin malformations in a neonatal foal tested homozygous positive for Warmblood Fragile Foal Syndrome. BMC VETERINARY RESEARCH 11:-(2015).
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