POLE
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Official Full Name
polymerase (DNA directed), epsilon -
Overview
Participates in DNA repair and in chromosomal DNA replication. -
Synonyms
POLE;polymerase (DNA directed), epsilon;DNA polymerase epsilon catalytic subunit A;POLE1;DNA polymerase II subunit A;DPOE1_HUMAN;EC 2.7.7.7;Polymerase (DNA directed) epsilon;OTTHUMP00000237674;OTTHUMP00000237676
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| POLE-1522H | Recombinant Human POLE protein | E.coli | Human | Non |
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| POLE-6913Z | Recombinant Zebrafish POLE | Mammalian Cells | Zebrafish | His |
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| POLE-1390HCL | Recombinant Human POLE cell lysate | Human | Non |
|
Involved Pathway
POLE involved in several pathways and played different roles in them. We selected most pathways POLE participated on our site, such as Purine metabolism,Pyrimidine metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with POLE were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| DNA Replication | GMNN,RFC5,GINS4,DBF4,MCM10,MCM4,PRIM1,MCM6L,SSBP1,RNASEH2B |
| Pyrimidine metabolism | CTPS1A,DPYD,ITPA,AK9,PNP6,POLR2G,DPYS,POLR2EB,NT5M,CANT1 |
| Base excision repair | NEIL3,UNGA,PARP3,POLE4,PARP2,OGG1,UNG,PARP1,TDG,NEIL1 |
| HTLV-I infection | FZD8,LTBR,NFATC1,WNT10B,HLA-DPB1,MSX1,IL2RG,TP53INP1,NFATC3,VDAC1 |
| Purine metabolism | POLR2B,ENTPD3,ENTPD4,PGM2,PDE4D,NT5C1BA,NT5M,IMPDH2,NPR1A,NME2B.2 |
| Metabolic pathways | HMBSA,LDHB,CYP2C54,MAN1A2,ALG2,NME3,PTGDS,PGAM1,CYP2C37,POLR3GLB |
| Nucleotide Excision Repair | COPS6,RPA4,PCNA,CCNH,RPA3,POLE4,ACTR5,INO80,POLE3,RFC2 |
Protein Function
POLE has several biochemical functions, for example, 3-5 exonuclease activity,4 iron, 4 sulfur cluster binding,DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by POLE itself. We selected most functions POLE had, and list some proteins which have the same functions with POLE. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | POU3F2A,ZFP593,CIC,ZFP110,HSF5,HIST1H47,TRIM21,ZNF131,RBM5,HIST1H2BH |
| nucleotide binding | MAP4K6,WRNIP1,BMPR1BA,FLJ11011L,RBM39A,MKNK2B,SRSF10,RALY,EPHA4B,SSB |
| chromatin binding | BRD3,MSL1,TOX3,HIST2H3C1,RNF2,FABP1,CREB3,RNF20,SIRT7,NFATC3 |
| 3-5 exonuclease activity | RAD9A,APEX1,APLF,RAD1,EXOSC10,POLG,TREX1,EXD1,REXO2,RAD9 |
| zinc ion binding | MT1F,MIB1,JADE1,NR1H4,PHRF1,SIAH1,Npepo,ZDHHC7,ZMYM4,TRIM21 |
| DNA-directed DNA polymerase activity | POLD2,POLE4,POLG2,CCDC111,POLI,CHRAC1,POLL,PRIMPOL,POLM,POLD4 |
| 4 iron, 4 sulfur cluster binding | TYW1,IREB2,TYW1B,ISCU,EXO5,RTEL1,SDHB,NDUFS7,RSAD1,DDX11 |
Interacting Protein
POLE has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POLE here. Most of them are supplied by our site. Hope this information will be useful for your research of POLE.
MYC;POLE3;ORF;LRRK2;STK19;KDM4A;POLE2;SNW1;POLE4
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References
- Shrivastava, A; Lele, PP; et al. A Rotary Motor Drives Flavobacterium Gliding. CURRENT BIOLOGY 25:338-341(2015).
- Russo, DM; Abdian, PL; et al. Lipopolysaccharide O-Chain Core Region Required for Cellular Cohesion and Compaction of In Vitro and Root Biofilms Developed by Rhizobium leguminosarum. APPLIED AND ENVIRONMENTAL MICROBIOLOGY 81:1013-1023(2015).
