POLE

  • Official Full Name

    polymerase (DNA directed), epsilon
  • Overview

    Participates in DNA repair and in chromosomal DNA replication.
  • Synonyms

    POLE;polymerase (DNA directed), epsilon;DNA polymerase epsilon catalytic subunit A;POLE1;DNA polymerase II subunit A;DPOE1_HUMAN;EC 2.7.7.7;Polymerase (DNA directed) epsilon;OTTHUMP00000237674;OTTHUMP00000237676
Cat.# Product name Source (Host) Species Tag Protein Length Price
POLE-1522H Recombinant Human POLE protein E.coli Human Non
POLE-6913Z Recombinant Zebrafish POLE Mammalian Cells Zebrafish His
POLE-1390HCL Recombinant Human POLE cell lysate Human Non

    Involved Pathway

    POLE involved in several pathways and played different roles in them. We selected most pathways POLE participated on our site, such as Purine metabolism,Pyrimidine metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with POLE were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Base excision repair PARP2,POLD3,OGG1,HMGB1A,APEX2,PNKP,NEIL3,TDG,POLE3,MPG
    Nucleotide Excision Repair GTF2H5,LIG1,RPA2,POLE3,ZFP830,RFC2,MNAT1,ERCC5,COPS6,INO80
    Purine metabolism GART,NT5C3B,PDE7B,AMPD3B,AK2,POLR2J2,XDH,CECR1,NUDT5,PDE6A
    Pyrimidine metabolism POLR2H,ENTPD6,NT5C1A,POLE3,DPYDA.1,POLR2J2,UMPS,DCK,UCKL1,CANT1A
    DNA Replication SSBP1,rnhA,DBF4,RFC5,GINS3,RFC1,MCM6L,POLD1,RPA1,POLD2
    HTLV-I infection TP53INP1,WNT8A,VDAC3,TCF3,WNT1,MAP2K4,SMAD2,FOS,HLA-DPB1,WNT7B
    Metabolic pathways ARG2,B3GNT5A,NANP,CSAD,PIGX,IMPA1,GLCE,GPT,GPT2,G6PC

    Protein Function

    POLE has several biochemical functions, for example, 3-5 exonuclease activity,4 iron, 4 sulfur cluster binding,DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by POLE itself. We selected most functions POLE had, and list some proteins which have the same functions with POLE. You can find most of the proteins on our site.

    Function Related Protein
    3-5 exonuclease activity RAD9B,RAD9A,APEX1,POLG,WRN,EXD2,RAD1,REXO2,RAD9,REV3L
    DNA-directed DNA polymerase activity POLK,POLN,POLB,MYBBP1A,POLM,POLD2,POLE3,POLA1,CHRAC1,POLE4
    chromatin binding SMC3,POLR2B,JMJD5,POLA1,SIRT2,NSBP1,TCF7L1A,SP140,TCF7L2,ATAD2B
    nucleotide binding DHX37,SIK2A,HSP70L,SNRKB,ARL3L1,RALYL,RBM12B2,CCC2,TSSK5,STK30
    4 iron, 4 sulfur cluster binding NUBP2,ISCA2,DNA2,POLA1,NDUFV1,NUBP1,ACO2,EXO5,MUTYH,ISCA1
    zinc ion binding RNF34B,PCGF5B,TRAF4A,NR1H2,TP53I3,BPTF,MICALL2A,TAF15,ASTL,TLL2
    DNA binding DACH2,ZNF653,ACD,CENPA,ZFP39,HOXC13,YBX1,MEIS1B,RORA,ZNF558

    Interacting Protein

    POLE has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POLE here. Most of them are supplied by our site. Hope this information will be useful for your research of POLE.

    MYC;POLE3;ORF;LRRK2;STK19;KDM4A;POLE2;SNW1;POLE4

    Resources

    References

    • Shrivastava, A; Lele, PP; et al. A Rotary Motor Drives Flavobacterium Gliding. CURRENT BIOLOGY 25:338-341(2015).
    • Russo, DM; Abdian, PL; et al. Lipopolysaccharide O-Chain Core Region Required for Cellular Cohesion and Compaction of In Vitro and Root Biofilms Developed by Rhizobium leguminosarum. APPLIED AND ENVIRONMENTAL MICROBIOLOGY 81:1013-1023(2015).

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