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POLE2

  • Official Full Name

    polymerase (DNA directed), epsilon 2 (p59 subunit)

  • Overview

    DNA polymerase epsilon subunit 2?is an?enzyme?that in humans is encoded by the?POLE2?gene.
  • Synonyms

    POLE2; polymerase (DNA directed), epsilon 2 (p59 subunit); DNA polymerase epsilon subunit 2; DPE2; DNA polymerase II subunit 2; DNA polymerase epsilon subunit B;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Zebrafish
  • HEK293
  • HEK293T
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human POLE2-2454H Recombinant Human POLE2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human POLE2-2637H Recombinant Human POLE2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse POLE2-13075M Recombinant Mouse POLE2 Protein Mammalian Cell His
Mouse POLE2-6907M-B Recombinant Mouse POLE2 Protein Pre-coupled Magnetic Beads HEK293
Mouse POLE2-6907M Recombinant Mouse POLE2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish POLE2-9520Z Recombinant Zebrafish POLE2 Mammalian Cell His
Chicken POLE2-1632C Recombinant Chicken POLE2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • POLE2 Related Articles

POLE2 involved in several pathways and played different roles in them. We selected most pathways POLE2 participated on our site, such as Purine metabolism, Pyrimidine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with POLE2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Purine metabolismPOLR3B;GUCY1A3;PAPSS2A;POLE4;PKM2;PDE3B;ADAL;POLR3A;PDE5A
Pyrimidine metabolismTXNRD2;POLA2;PRIM2;DTYMK;UPP1;TK1;DUT;UCK2;NME5
Metabolic pathwaysNT5M;MAN1A2;FDFT1;POLE4;MMAB;ME1;PCK2;OCRL;FUT4
DNA replicationFEN1;POLE;LIG1;POLE3;POLA1;DNA2;MCM7;RNASEH2B;GMNN
Base excision repairTDG.1;APEX1;NTHL1;PNKP;POLD3;MUTYH;HMGB1A;TDG;NEIL3
Nucleotide excision repairKIAA1530;INO80C;INO80E;RFC1;GTF2H2C;LIG1;RAD23B;XPC;GTF2H5
HTLV-I infectionSLC25A6;DVL2;GM-CSF;PIK3CG;SRF;APC2;WNT8A;HLA-DMA;HLA-DOA

POLE2 has several biochemical functions, for example, DNA binding, contributes_to DNA-directed DNA polymerase activity, nucleotidyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by POLE2 itself. We selected most functions POLE2 had, and list some proteins which have the same functions with POLE2. You can find most of the proteins on our site.

Function Related Protein
DNA bindingNR5A1;LIG3;HIST1H2AI;MAFGB;POLE2;DNMT3A;TMPOA;ZFAND5;HOXA4A
contributes_to DNA-directed DNA polymerase activity
nucleotidyltransferase activityTERT;CMASB;POLN;GMPPAB;POLE2;GMPPAA;CMASA;MOCS3;GDPGP1
transferase activityANKK1;ACLYA;ILVBL;PNP4B;MAPKAPK2B;SULT3ST3;CML5;EHMT1A;NUCKS1A

POLE2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POLE2 here. Most of them are supplied by our site. Hope this information will be useful for your research of POLE2.

Chao, YH; Wu, KH; et al. Downregulated CXCL12 expression in mesenchymal stem cells associated with severe aplastic anemia in children. ANNALS OF HEMATOLOGY 94:13-22(2015).
Liu, D; Zhang, XX; et al. Sine oculis homeobox homolog 1 promotes DNA replication and cell proliferation in cervical cancer. INTERNATIONAL JOURNAL OF ONCOLOGY 45:1232-1240(2014).
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