POU2F1
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Official Full Name
POU class 2 homeobox 1 -
Overview
The OCT1 transcription factor was among the first identified members of the POU transcription factor family (summarized by Sturm et al., 1993 (PubMed 8314572)). Members of this family contain the POU domain, a 160-amino acid region necessary for DNA binding to the octameric sequence ATGCAAAT. -
Synonyms
POU2F1;POU class 2 homeobox 1;OTF1, POU domain class 2, transcription factor 1;POU domain, class 2, transcription factor 1;OCT1;NF-A1;OTF-1;oct-1;octamer-binding protein 1;Octamer-binding transcription factor-1;octamer-binding transcription factor 1;OTF1;oct-1B;FLJ42836
Recombinant Proteins
- Mouse
- Rat
- Chicken
- Human
- Mammalian Cells
- E.coli
- HEK293
- His
- T7
- GST
- Non
- DDK
- Myc
- Avi
- Fc
Involved Pathway
POU2F1 involved in several pathways and played different roles in them. We selected most pathways POU2F1 participated on our site, such as ATF-2 transcription factor network,Calcineurin-regulated NFAT-dependent transcription in lymphocytes,Calcium signaling in the CD4+ TCR pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with POU2F1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RNA Polymerase III Abortive And Retractive Initiation | SNAPC5,GTF3C4,CRCP,GTF3C2,GTF3C5,NFIB,ZNF143,GTF3C3,SNAPC2,BRF2 |
| ATF-2 transcription factor network | CSRP2,DUSP1,JUN,GADD45A,DDIT3,JUNB,RUVBL2,DUSP10,KCNA3,MAPK14 |
| Glucocorticoid receptor regulatory network | CSN2,KRT5,SMARCA4,BGLAP,KRT14,SMARCC2,KRT17,SMARCD1,NR1I3,EGR1 |
| Calcium signaling in the CD4+ TCR pathway | FKBP1A,CSF2,CHP,RCAN1,AKAP5,RCAN2,JUNB,BATF3 |
| Gene Expression | NR5A1,POU2F1B,POLR3C,MED25,ZNF776,THG1L,CDKAL1,MED6,C14orf166,ZNF556 |
| RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription | MTA3,ZNF143,GTF3C2,BRF1B,GTF3AA,GTF3C4,NFIA,SNAPC1,SNAPC3,SNAPC1B |
| Calcineurin-regulated NFAT-dependent transcription in lymphocytes | IRF4,DGKA,CSF2,CTLA4,IKZF1,JUNB,BATF3,EGR4,EGR1,EGR2 |
| FOXA1 transcription factor network | NRIP1,CC10,FOXA1,DSCAM,NFIB,NR2F2,NFIA,CYP2C18,AP1B1,CEBPB |
Protein Function
POU2F1 has several biochemical functions, for example, chromatin binding,protein binding,receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by POU2F1 itself. We selected most functions POU2F1 had, and list some proteins which have the same functions with POU2F1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | PIP5K1C,RBM10,KRAS,PARK7,DLX2,NTHL1,KLHL6,UBXN6,H2AFZ,PFDN5 |
| chromatin binding | HDAC7,PHF21A,ATOH1A,NSD1,TRP63,MEN1,TAL1,MECP2,NUPR1,ASF1A |
| sequence-specific DNA binding | DBPA,LHX2,IRF4,FOXH1,HOXD9A,IRX4A,ESRRA,HOXC4A,FEV,ENG1B |
| transcription factor activity, sequence-specific DNA binding | XBP1,RXRA,ZNF256,KLF12,KLF10,RARA,ZNF436,ZFP354C,ZKSCAN6,ELF2 |
| receptor binding | FGF12B,CNPY4,IDE,DDX54,PTK2BB,TDGF1,WNT5B,RND1,NCR3,CADM1 |
| transcription regulatory region sequence-specific DNA binding | NR5A1A,CRY2,NFE2L2A,CREB3L3,MEF2CA,SOX4,NFE2L1B,KCNA3,NFE2,TBX18 |
Interacting Protein
POU2F1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POU2F1 here. Most of them are supplied by our site. Hope this information will be useful for your research of POU2F1.
SP1;SP4;POGZ;PLK3;TEAD1;rta_ebvb9
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References
- Vieweg, M; Dvorakova-Hortova, K; et al. Methylation analysis of histone H4K12ac-associated promoters in sperm of healthy donors and subfertile patients. CLINICAL EPIGENETICS 7:-(2015).
- Balint, BL; Gabor, P; et al. Genome-wide localization of histone 4 arginine 3 methylation in a differentiation primed myeloid leukemia cell line. IMMUNOBIOLOGY 210:141-152(2005).
