PPAP2C
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Official Full Name
phosphatidic acid phosphatase type 2C -
Overview
The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is similar to phosphatidic acid phosphatase type 2A (PPAP2A) and type 2B (PPAP2B). All three proteins contain 6 transmembrane regions, and a consensus N-glycosylation site. This protein has been shown to possess membrane associated PAP activity. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. -
Synonyms
PPAP2C;phosphatidic acid phosphatase type 2C;lipid phosphate phosphohydrolase 2;LPP2;PAP 2c;EC 3.1.3.4;PAP2 G;PAP2 gamma;PAP2c;PAP2G;Phosphatidate phosphohydrolase type 2c;Phosphatidic acid phosphatase 2c;Phosphatidic acid phosphohydrolase type 2c;Type 2 phosphatidic acid phosphatase gamma;PAP2-gamma;type-2 phosphatidic acid phosphatase-gamma;PAP-2c;PAP2-g
Recombinant Proteins
- Mouse
- Rat
- Human
- Mammalian Cells
- E.coli
- HEK293
- His
- GST
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PPAP2C-13156M | Recombinant Mouse PPAP2C Protein | Mammalian Cells | Mouse | His |
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| PPAP2C-4589R | Recombinant Rat PPAP2C Protein | Mammalian Cells | Rat | His |
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| PPAP2C-1959H | Recombinant Human PPAP2C Protein, His&GST-tagged | E.coli | Human | GST&His | Met1-Leu162 |
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| PPAP2C-4249R | Recombinant Rat PPAP2C Protein, His (Fc)-Avi-tagged | HEK293 | Rat | Avi&Fc&His |
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| PPAP2C-4249R-B | Recombinant Rat PPAP2C Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| PPAP2C-6964M | Recombinant Mouse PPAP2C Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| PPAP2C-6964M-B | Recombinant Mouse PPAP2C Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
PPAP2C involved in several pathways and played different roles in them. We selected most pathways PPAP2C participated on our site, such as Glycerolipid metabolism,Glycerophospholipid metabolism,Ether lipid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPAP2C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Choline metabolism in cancer | SLC22A3,RAC3,MAPK9,DGKD,PLA2G4B,WASF1,WASF3,PRKCG,FOS,RPS6KB1 |
| Metabolic pathways | CNDP1,PNP,LASS4,GBE1,AMY2A2,TPI1,G6PCA.1,AOX4,TPH1A,PDXKA |
| Glycerophospholipid metabolism | ACHE,MBOAT2B,MBOAT2,PHYKPL,PMT,TESCA,PLA2G3,LPGAT1,GPD2,PPAP2D |
| Phospholipase D signaling pathway | NRAS,RALGDS,DGKE,PLCB1,LPAR6,MS4A2,FCER1A,PLCB3,SOS1,Pdgfa&Pdgfb |
| Glycerolipid metabolism | AKR1B1,ALDH7A1,GK,STIL,AKR1B1L,DGAT1A,DGKB,PPAP2A,CELL,DGKZ |
| Fc gamma R-mediated phagocytosis | INPP5D,MARCKSL1,PLA2G6,INPPL1,SYK,WAS,PIK3R2,PRKCG,FCGR2A,PLCG1 |
| Sphingolipid metabolism | CERS2A,GALC,SPTLC2,SMPD3,DEGS1,ACER3,SMPD2,SGMS2,GALCB,GBA |
| Ether lipid metabolism | AGPS,EPT1,ENPP6,LPCAT4,PLA2G6,PLA2G16,PLA2G2D,PLD2,PLA2G4F,PPAP2A |
| Fat digestion and absorption | PPAP2A,ABCA1,PPAP2B,SLC27A4,PLA2G2F,GOT2,APOA4,PLA2G5,PLA2G10,MOGAT3 |
Protein Function
PPAP2C has several biochemical functions, for example, hydrolase activity,lipid phosphatase activity,phosphatidate phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPAP2C itself. We selected most functions PPAP2C had, and list some proteins which have the same functions with PPAP2C. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| lipid phosphatase activity | INPP5K,PPAP2D,PPAP2A,PPAP2B,PTENB,LPPR3,LPPR1,LPPR5B,PTENA,PPAP2CB |
| hydrolase activity | SSH2B,UFSP2,EAR2,CES3A,RNASEL4,HTRA1B,ANG4,ATP13A3,DUSP23B,IRGM |
| phosphatidate phosphatase activity | PPAP2A,LPPR3,PPAP2CB,LPIN1,STIL,LPIN2,LPIN3,PPAPDC1B,PPAP2B,PPAPDC1A |
Interacting Protein
PPAP2C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPAP2C here. Most of them are supplied by our site. Hope this information will be useful for your research of PPAP2C.
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References
- Qu, YN; An, ZF; et al. Copper amine oxidase and phospholipase D act independently in abscisic acid (ABA)-induced stomatal closure in Vicia faba and Arabidopsis. JOURNAL OF PLANT RESEARCH 127:533-544(2014).
- Zhang, YY; Zhu, HY; et al. Phospholipase D alpha 1 and Phosphatidic Acid Regulate NADPH Oxidase Activity and Production of Reactive Oxygen Species in ABA-Mediated Stomatal Closure in Arabidopsis. PLANT CELL 21:2357-2377(2009).
