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PPEF2

Official Full Name

protein phosphatase, EF-hand calcium binding domain 2
Overview

This gene encodes a member of the serine/threonine protein phosphatase with EF-hand motif family. The protein contains a protein phosphatase catalytic domain, and at least two EF-hand calcium-binding motifs in its C terminus. Although its substrate(s) is unknown, the encoded protein, which is expressed specifically in photoreceptors and the pineal, has been suggested to play a role in the visual system. This gene shares high sequence similarity with the Drosophila retinal degeneration C (rdgC) gene.
Synonyms

PPEF2; protein phosphatase, EF-hand calcium binding domain 2; serine/threonine-protein phosphatase with EF-hands 2; PPP7CB; protein phosphatase 7; catalytic subunit; beta isozyme; protein phosphatase with EF hands 2; protein phosphatase, EF hand calcium-b;

Species	Cat.#	Product name	Source (Host)	Tag	Price
Mouse	PPEF2-13171M	Recombinant Mouse PPEF2 Protein	Mammalian Cell	His	Inquiry
Mouse	PPEF2-6975M-B	Recombinant Mouse PPEF2 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Mouse	PPEF2-6975M	Recombinant Mouse PPEF2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry

Involved Pathway
Protein Function
Interacting Protein
PPEF2 Related Articles

PPEF2 involved in several pathways and played different roles in them. We selected most pathways PPEF2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PPEF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

PPEF2 has several biochemical functions, for example, Hsp70 protein binding, Hsp90 protein binding, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PPEF2 itself. We selected most functions PPEF2 had, and list some proteins which have the same functions with PPEF2. You can find most of the proteins on our site.

Function	Related Protein
Hsp70 protein binding	STIP1;FAM119A;ST13;DNAJB2;METTL21A;TSACC;CDKN1B;C11orf73;CDK1
Hsp90 protein binding	NASP;CSNK2A1;PACRG;EIF2AK3;PPEF2;HDAC6;STUB1;USP19;CHORDC1
calcium ion binding	CSN2;PPEF1;NKD1;SLC24A2;ICN2;THBS3;EFCAB4B;STIM1;FKBP10
hydrolase activity	TDRD9;GNPDA2;ATP2B3A;SPO11;PGAM1;CPSF3L;METAP2A;EAR5;AGBL1
iron ion binding	CYP2D10;NDOR1;CYP2J2;IRGM1;ALOX5;CYP2AA6;CYP7B1;CYP1A;Scd1
manganese ion binding	FEN1;PPM1BB;GYLTL1B;SLC11A2;PPM1N;PPM1AB;NUDT7;PAPOLA;B4GALT7
metal ion binding	ZNF521;PHF2;RNF220A;NEK8;ZNF45;MTMR4;DDAH1;ZSWIM4;FAH
mitogen-activated protein kinase kinase kinase binding	CDC42;MAP3K11;MAPK1;TCF3;MAPK8IP3;DUSP19;MAP4K2;STK38;CDC37
phosphoprotein phosphatase activity	DUSP22B;DLGAP5;CTDSPL2;PPAP2B;PPP3CC;CTDNEP1A;PPM1AA;DUSP26;PTPRQ
protein serine/threonine phosphatase activity	PPA2;DUSP23B;PPP2R2A;PDP2;CDC14AA;DUSP23;CDC14B;PTEN;PPP2R1A

PPEF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPEF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PPEF2.

Dovega, R; Tsutakawa, S; et al. Structural and Biochemical Characterization of Human PR70 in Isolation and in Complex with the Scaffolding Subunit of Protein Phosphatase 2A. PLOS ONE 9:-(2014).

Yamaguchi, M; et al. The anti-apoptotic effect of regucalcin is mediated through multisignaling pathways. APOPTOSIS 18:1145-1153(2013).