PPM1A

  • Official Full Name

    protein phosphatase, Mg2+/Mn2+ dependent, 1A

  • Overview

    The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
  • Synonyms

    PPM1A; protein phosphatase, Mg2+/Mn2+ dependent, 1A; protein phosphatase 1A (formerly 2C), magnesium dependent, alpha isoform; protein phosphatase 1A; MGC9201; phosphatase 2C alpha; PP2CA; PP2Calpha; protein phosphatase 2C; alpha isoform; protein phosphat;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PPM1A-862H Active Recombinant Human PPM1A Protein, His-tagged E.coli His Gly2-Lys324
Human PPM1A-66H Recombinant Human PPM1A, His-tagged E.coli His
Human PPM1A-2543H Recombinant Human PPM1A protein, His-tagged E.coli His Met1-Trp382
Human PPM1A-1893H Recombinant Human PPM1A, GST-tagged E.coli GST C-term-334aa
Human PPM1A-31047TH Recombinant Human PPM1A, His-tagged E.coli His
Human PPM1A-2964HCL Recombinant Human PPM1A 293 Cell Lysate HEK293 N/A
Human PPM1A-5955H Recombinant Human PPM1A Protein (Gly2-Trp382), C-His tagged E.coli C-His Gly2-Trp382
Human PPM1A-4860H Recombinant Human PPM1A Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PPM1A-725H Recombinant Human PPM1A Protein, His-tagged E.coli His Gly2~Try382
Human PPM1A-3364H Recombinant Human PPM1A protein, GST-tagged E.coli GST 1-382aa
Mouse PPM1A-13195M Recombinant Mouse PPM1A Protein Mammalian Cell His
Mouse Ppm1a-766M Recombinant Mouse PPM1A protein(Met1-Trp382), His-tagged E.coli C-His Met1-Trp382
Mouse Ppm1a-5045M Recombinant Mouse Ppm1a Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse PPM1A-6990M-B Recombinant Mouse PPM1A Protein Pre-coupled Magnetic Beads HEK293
Mouse PPM1A-6990M Recombinant Mouse PPM1A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PPM1A-4606R Recombinant Rat PPM1A Protein Mammalian Cell His
Rat PPM1A-4265R Recombinant Rat PPM1A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PPM1A-4265R-B Recombinant Rat PPM1A Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

PPM1A involved in several pathways and played different roles in them. We selected most pathways PPM1A participated on our site, such as MAPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPM1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayTMEM37;RASA1;Fasl;PPP3CA;MAP3K13;TAOK2;MAPK8;RAC1A;HSPA8

PPM1A has several biochemical functions, for example, R-SMAD binding, calmodulin-dependent protein phosphatase activity, magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PPM1A itself. We selected most functions PPM1A had, and list some proteins which have the same functions with PPM1A. You can find most of the proteins on our site.

Function Related Protein
R-SMAD bindingJUN;FOS;MYOCD;SMAD4;CTNNB1;RANBP3;TRIM33;PPM1A;ZEB2
calmodulin-dependent protein phosphatase activityPPP3CA;PPM1A;PPP3CB;PPM1F
magnesium ion bindingRPS6KA1;ENO2;ZNF143B;PTEN;NUDT3;COMT;ERN2;RPS6KA5;PPM1AA
manganese ion bindingTDP2B;B4GALT7;PPEF1;ME1;PPM1B;TDP2;MTPAP;B4GALT1;XPNPEP3
protein C-terminus bindingERCC3;PPP1R9B;HIC2;ATXN2;PICK1;SHANK3;VPS4A;ITPR1;SDCBP
protein bindingTTC17;TRIP10;CACNB4;SOST;CISH;SORCS1;MMP14;SLC30A8;STAT5A
protein serine/threonine phosphatase activityPPM1DA;PPP1CC;PPM1BA;PHLPP2;PPM1E;PPM1LB;DULLARD;MTMR4;CDC14AA
signal transducer activityMRGPRB3;AVPR2L;OLFR15;CC2D1A;EEF1D;TAS2R113;GNGT2A;OLFR480;PLCB4

PPM1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPM1A here. Most of them are supplied by our site. Hope this information will be useful for your research of PPM1A.

MAPK1; RANBP3

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