PPP3CA
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Official Full Name
protein phosphatase 3, catalytic subunit, alpha isozyme -
Overview
Calcineurin (CN) is a protein phosphatase also known as protein phosphatase 3, PPP3CA, and calcium-dependent serine-threonine phosphatase, and formerly known as protein phosphatase 2B (PP2B).It activates the T cells of the immune system and can be blo -
Synonyms
PPP3CA;protein phosphatase 3, catalytic subunit, alpha isozyme;CALN, CALNA, protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform , protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform (calcineurin A alpha);serine/thr
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Zebrafish
- CHO
- E.coli
- Mammalian Cells
- Insect Cells
- HEK293
- Fc
- GST
- His
- Non
- Avi
Involved Pathway
PPP3CA involved in several pathways and played different roles in them. We selected most pathways PPP3CA participated on our site, such as MAPK signaling pathway,Calcium signaling pathway,cGMP-PKG signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPP3CA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Osteoclast differentiation | FOSL2,FCGR2A,FCGR1,AKT2,PPP3R1,LILRA3,LILRB2,STAT2,FCGR1A,IL1B |
| cGMP-PKG signaling pathway | ATP1A4,NPR1,GNAI1,MYLK4,PIK3R5,GTF2I,KCNMB3,ATP1B4,SLC25A31,AGTR1B |
| HTLV-I infection | XPO1,CD3E,CALR,HLA-DRB3,FOS,CDC20,ANAPC7,RANBP1,VAC14,XIAP |
| Alzheimers disease | EIF2AK3,MT-ATP6,PPP3CB,COX6B1,CASP12,COX5B,BACE1,NDUFS7,NDUFC2,LPL |
| Tuberculosis | EP300,HLA-DQA2,BID,FCGR4,RAB5C,IFNA12,FCGR3,IFNA17,ATP6V0A4,Il23a; Il12b |
| Oocyte meiosis | CAMK2B,PPP2R5C,CALM2B,MAD2L1,IGF1R,PPP3CC,CUL1A,RPS6KA1,PLCZ1,YWHAH |
| Natural killer cell mediated cytotoxicity | ITGB2L,ICAM1,RAF1,RAC1,KIR2DL3,BRAF,KLRK1,ULBP2,IFNA7,TNFRSF10D |
| Apoptosis | GZMC,LMNB1,PPP3R1B,PRKAR1AB,PRKAR2AA,NTRK1,Casp3,IL1RAP,IL1R1,STK26 |
| Dopaminergic synapse | CALM3,GRIA2,GNAS,CALML3,GSK3A,AKT2,GRIA3,DRD3,TH,GNAI3 |
Protein Function
PPP3CA has several biochemical functions, for example, calcium ion binding,calmodulin binding,calmodulin-dependent protein phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPP3CA itself. We selected most functions PPP3CA had, and list some proteins which have the same functions with PPP3CA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| enzyme binding | ZFHX3,PTEN,CASP2,CD4,TARBP2,USF1,PLSCR4,HIF1A,ZNF346,PRKCE |
| protein heterodimerization activity | APOA2,HIST1H4A,SCUBE1,PRSS28,GRIN2A,BNIP3L,MAFG,PAFAH1B2,TIRAP,IKBKB |
| protein binding | TEKT4,ACAN,CABLES1,IL7,KRTAP10-7,PRAC,CATSPER1,TP53,SPARC,TMPRSS4 |
| calcium ion binding | TESC,PCDHGC3,ANXA11A,NID2,MBL2,SYT1B,PCDHB1,STIM2,NOTCH1A,FAT4 |
| calmodulin-dependent protein phosphatase activity | PPM1A,PPP3CB,PPM1F |
| protein serine/threonine phosphatase activity | MTMR6,PPM1NB,PPP1CC,PPM1E,PHLPP2,DULLARD,DUSP23,PPM1L,PPM1DA,PPEF1 |
| protein dimerization activity | CREB3,LDB1A,MYCLB,AIFM1,ATOH7,PIP,NEUROG3,TWIST1B,WWOX,GGN |
| calmodulin binding | MYO1A,PHKG1,MKNK1,KCNN3,TRPV6,MYH3,SPATA17,MAPKAPK2,PPP3CB,KCNN1 |
| drug binding | TYMS,CHRNB3,SMO,PDXK,PIGC,CHRNA7,SIGMAR1,MT3,PDE4C,P2RX1 |
Interacting Protein
PPP3CA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPP3CA here. Most of them are supplied by our site. Hope this information will be useful for your research of PPP3CA.
PPP3R1;GRB2;C16orf74;Cacng8;USP14;LASP1;Kcnj8;Nfatc1;ABL1
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