Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953 Learn More

PRICKLE1

Official Full Name

prickle homolog 1 (Drosophila)
Overview

This gene encodes a nuclear receptor that may be a negative regulator of the Wnt/beta-catenin signaling pathway. The encoded protein localizes to the nuclear membrane and has been implicated in the nuclear trafficking of the transcription repressors REST/NRSF and REST4. Mutations in this gene have been linked to progressive myoclonus epilepsy. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 3.
Synonyms

PRICKLE1; prickle homolog 1 (Drosophila); prickle like 1 (Drosophila); prickle-like protein 1; EPM1B; FLJ31937; FLJ31627; MGC138902; MGC138903; Prickle 1; Prickle like protein 1; Prickle-like 1; REST-Interacting LIM Domain Protein; REST/NRSF interacting LIM domain protein 1; RILP; REST/NRSF-interacting LIM domain protein 1; REST (RE-1 silencing transcription factor)/NRSF (neuron-restrictive silencer factor)-interacting LIM domain protein;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	PRICKLE1-1943H	Recombinant Human PRICKLE1, GST-tagged	E.coli	GST	321-580aa	$319 / 25ug
Human	PRICKLE1-2871HCL	Recombinant Human PRICKLE1 293 Cell Lysate	HEK293	N/A		Inquiry
Mouse	PRICKLE1-13342M	Recombinant Mouse PRICKLE1 Protein	Mammalian Cell	His		Inquiry
Mouse	PRICKLE1-7081M	Recombinant Mouse PRICKLE1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	PRICKLE1-7081M-B	Recombinant Mouse PRICKLE1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein

PRICKLE1 involved in several pathways and played different roles in them. We selected most pathways PRICKLE1 participated on our site, such as Asymmetric localization of PCP proteins, Beta-catenin independent WNT signaling, PCP/CE pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRICKLE1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Asymmetric localization of PCP proteins	DVL2;PRICKLE1;PRICKLE1B
Beta-catenin independent WNT signaling	PRICKLE1;GNB5;AGO3;AP2B1;AP2A2;DVL1;ROR2;AGO1;CLTC
PCP/CE pathway	ROR1;ROR2;PRICKLE1;RYK;PRICKLE1B
Signal Transduction	USP34;EVC;FSTL3;OR2AP1;TAC3;AKAP13;RDH14;RGS18;RHOJ
Signaling by Wnt	ZNRF3;TNKS;SOX9A;RYK;AES;LGR6;WNT8-2;SOX6;SOX4A
Wnt signaling pathway	PRKCB;FBXW2;PRICKLE1A;ROCK2A;WNT2BB;RHOAC;WNT3;PRKACA;WNT6

PRICKLE1 has several biochemical functions, for example, protein binding, transcription factor binding, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRICKLE1 itself. We selected most functions PRICKLE1 had, and list some proteins which have the same functions with PRICKLE1. You can find most of the proteins on our site.

Function	Related Protein
protein binding	PGR;RAB6A;GPAA1;PRKD3;RTN4RL1;FAM96B;MANBAL;CHMP1B;DNAJC5B
transcription factor binding	GPX3;CEBPA;SOX8;HDAC4;DIP2B;ZBTB49;NR0B1;Ar;PPRC1
zinc ion binding	RABGGTA;NR1D4B;ZRANB1B;TRIM63;RPH3A;ADAM2;KAT6B;TRIM2;MLLT10

PRICKLE1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRICKLE1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRICKLE1.

Rest; PRPF31; UTP14C; Smurf2; DVL2; DVL3; Pard6a; RASSF10