PRIM2
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Official Full Name
primase, DNA, polypeptide 2 (58kDa) -
Overview
The replication of DNA in eukaryotic cells is carried out by a complex chromosomal replication apparatus, in which DNA polymerase alpha and primase are two key enzymatic components. Primase, which is a heterodimer of a small subunit and a large subunit, synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. The protein encoded by this gene is the large, 58 kDa primase subunit. -
Synonyms
PRIM2;primase, DNA, polypeptide 2 (58kDa);PRIM2A, primase, polypeptide 2A (58kD) , primase, polypeptide 2A, 58kDa;DNA primase large subunit;DNA primase 58kDa subunit;DNA primase p58;DNA primase subunit p58;p58;Polypeptide 2A p58;PRIM2A;Primase DNA polypeptide 2 (58kDa);Primase polpeptide 2A (58kD);Primase polpeptide 2A 58kDa;dJ422B11.1.1;DNA primase 58 kDa subunit;primase polypeptide 2A, 58kDa
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Chicken
- Rhesus macaque
- E.coli
- Mammalian Cells
- HEK293
- His
- DDK
- Myc
- Avi
- Fc
Involved Pathway
PRIM2 involved in several pathways and played different roles in them. We selected most pathways PRIM2 participated on our site, such as Purine metabolism,Pyrimidine metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRIM2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| DNA Replication | MCM6L,CDT1,POLD4,LIG1,POLE2,RFC4,SSBP1,MCM10,FEN1,MCM2 |
| Pyrimidine metabolism | NT5C3B,CTPS2,POLR3D,NT5C2A,POLR1E,DPYS,POLR3GL,POLR1A,ENTPD8,PNP |
| Purine metabolism | IMPDH1A,POLA2,NME7,POLR1E,PDE7A,GDA,GART,POLR3B,IMPDH1B,UOX |
| Metabolic pathways | UGT8A,PYGB,CHIA,UGDH,GAA,PI4K2A,ACAT1,ST6GALNAC3,ACLY,HSD3B4 |
Protein Function
PRIM2 has several biochemical functions, for example, 4 iron, 4 sulfur cluster binding,ATP:coenzyme F420 adenylyltransferase activity,CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRIM2 itself. We selected most functions PRIM2 had, and list some proteins which have the same functions with PRIM2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA primase activity | PRIMPOL,CTU1,PRIM1,CCDC111,UAP1L1 |
| sulfate adenylyltransferase activity | CCDC111,CTU1,UAP1L1 |
| tRNA guanylyltransferase activity | CTU1,UAP1L1,CCDC111,USP14,THG1L |
| 4 iron, 4 sulfur cluster binding | NUBP2,BRIP1,ERCC2,EXO5,NFU1,NTHL1,ISCA1,RSAD2,NDUFS8B,NUBP1 |
| nucleotidyltransferase activity | OASL2,PAPSS1,POLE2,CCDC111,POLR3B,GMPPAA,GMPPA,GKUP,CMASB,CMASA |
| DNA/RNA helicase activity | CTU1,CCDC111,UAP1L1 |
| RNA guanylyltransferase activity | RNGTT,CCDC111,UAP1L1,CTU1 |
| CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase activity | UAP1L1,CCDC111,CTU1 |
| metal ion binding | ZNF280B,MGAT4B,SP9,TRIM35-35,KEX2,COL27A1A,ANKMY2,DNAJA1,TANK,SAR1B |
Interacting Protein
PRIM2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRIM2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRIM2.
Pola2;Iqcb1;Prim1;Pola1
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References
- Liu, D; Zhang, XX; et al. Sine oculis homeobox homolog 1 promotes DNA replication and cell proliferation in cervical cancer. INTERNATIONAL JOURNAL OF ONCOLOGY 45:1232-1240(2014).
- Chung, J; Tsai, S; et al. Lack of genomic imprinting of DNA primase, polypeptide 2 (PRIM2) in human term placenta and white blood cells. EPIGENETICS 7:429-431(2012).
