PRKCZ
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Official Full Name
PRKCZ protein kinase C, zeta
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Synonyms
PRKCZ; protein kinase C, zeta; protein kinase C zeta type; PKC2; nPKC-zeta; PKC-ZETA;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Insect (sf21)
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Sf21
- Sf9 Insect Cell
- Flag
- GST
- His
- His (Fc)
- Avi
- His|T7
- Myc
- DDK
- N/A
- N
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- PRKCZ Related Research Area
PRKCZ involved in several pathways and played different roles in them. We selected most pathways PRKCZ participated on our site, such as Rap signaling pathway, Chemokine signaling pathway, Sphingolipid signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRKCZ were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Rap signaling pathway | PLCE1;PDGFB;MAP2K3;RHOA;PRKD3;P2RY1;FGF10;INS2;Fgf15 |
| Chemokine signaling pathway | GNG4;WAS;LOC100033925;NFKBIB;RHOA;CCL28;CCR3;SRC;SHC4 |
| Sphingolipid signaling pathway | CERS4;ROCK2;SMPD2;ACER1;AKT2;GNA12;MAPK3;PTEN;AKT1 |
| Endocytosis | ZFYVE16;CAPZA1A;SMAD3;TFRC;RAB11A;RAB5C;STRUMPELLIN;ARF6A;CHMP5 |
| Hippo signaling pathway | YWHAH;GLI2;TEAD4;Fzd4;WNT4;BMP7;WNT8A;PPP2CB;DLG1 |
| Tight junction | MLLT4;TJAP1;ACTN4;MPDZ;PPP2R2CA;PTENA;MYL12.2;VMHC;RAB13 |
| Platelet activation | MYLK4;P2RY1;PIK3R2;FGG;AKT2;SNAP23;GUCY1B3;LYN;PRKACA |
| Insulin signaling pathway | MAPK10;PIK3CB;RAF1B;G6PC;PDPK1B;MAPK8A;MTOR;PHKG1;EIF4E1C |
| Type II diabetes mellitus | PIK3R5;INS;PKM;MAPK8;MAPK1;HKDC1;PIK3CG;PIK3R3;SOCS3 |
| Insulin resistance | AKT1;RPS6KA6;PPP1CB;FOXO1A;PPP1CAA;PRKCB;PRKCBB;GFPT2;PPP1R3A |
PRKCZ has several biochemical functions, for example, 14-3-3 protein binding, ATP binding, insulin receptor substrate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRKCZ itself. We selected most functions PRKCZ had, and list some proteins which have the same functions with PRKCZ. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 14-3-3 protein binding | TSC2;HDAC7A;KCNH1;HDAC7;AANAT;YWHAQ;IRS2;ZFP36;KIF13B |
| ATP binding | SWAP70;NLRC3;CKBB;PFKP;DDX28;AK5L;DNAHC8;TTLL6;LIMK1A |
| insulin receptor substrate binding | PIK3CB;PRKCZ;INSR;INSRA;GRB2;INSRB;JAK2;PIK3R1;IGF1RA |
| metal ion binding | CNBPA;ZSCAN20;NPEPPS;ITPK1A;CNOT4B;ZEB2B;NDUFS2;ZNF670;THOP1 |
| phospholipase binding | WAS;Pla2r1;CALM3;SNCA;CALM1;PRKCZ;NEFL;LMNB1;APOC2 |
| potassium channel regulator activity | SGK2B;KCNMB4;DRD4;DPP6;CHP;KCNMB3;KCNIP3;YWHAE;ANK2 |
| protein binding | RRP8;SDHAF2;PHOSPHO2;KIF6;GRIN1;COL6A5;KCP;WEE1;SSBP3 |
| protein domain specific binding | NR0B2;HIST1H4L;MTOR;CALM;PLAUR;OCLN;RUNX2;ICA1L;YWHAG1 |
| protein kinase C activity | PKN3;PRKCQ;PRKCI;PRKCDA;PRKCH;PRKCG;PRKCE;PRKCB;PKN2 |
| protein kinase activity | PRPF4BB;PRKCD;SBK3;PTK2;GSG2;PLK2B;PRKCI;CHEK1;ACVR1BA |
| protein kinase binding | NCS1;PEBP1;DOK7;KIF20A;SNAP91;MAP2K6;MAP3K5;GOLGA2;CDH2 |
| protein serine/threonine kinase activity | TESK2;PRKY;MAP3K12;PLK4;OBSCN;RIPK1;CDK1;MAPK4;TLK2 |
PRKCZ has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRKCZ here. Most of them are supplied by our site. Hope this information will be useful for your research of PRKCZ.
PARD6A; PARD6B; PRKCI; PARD6G
- Q&As
- Reviews
Q&As (5)
Ask a questionPRKCZ has been shown to promote cell migration and invasion, contributing to the metastatic potential of certain cancer types.
Yes, some trials explore PRKCZ inhibitors as potential treatments for certain cancers and neurological disorders.
PRKCZ is involved in insulin resistance, affecting the body's response to insulin, a key factor in type 2 diabetes.
Several compounds have been identified as potential inhibitors or activators of PRKCZ, although their clinical use is still under investigation.
PRKCZ is involved in immune cell function and the regulation of inflammatory responses, making it a potential target for managing such disorders.
Customer Reviews (3)
Write a reviewThis commitment to staying at the forefront of research translates directly to the quality and performance of the PRKCZ protein in my trials.
They monitor the latest advancements in the field and incorporate new findings into the production and characterization of the protein.
Their commitment to providing technical support is unparalleled, and their expertise can prove invaluable in navigating any challenges or troubleshooting that may arise during my experiments.
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