PROKR2

  • Official Full Name

    prokineticin receptor 2

  • Overview

    Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor for prokineticins. The encoded protein is similar in sequence to GPR73, another G protein-coupled receptor for prokineticins.

  • Synonyms

    PROKR2;prokineticin receptor 2;G protein coupled receptor 73 like 1 , GPR73L1, KAL3, Kallmann syndrome 3 (autosomal dominant);dJ680N4.3;GPR73b;GPRg2;PKR2;PK-R2;G protein-coupled receptor 73-like 1;KAL3;GPR73L1

Recombinant Proteins

  • Mouse
  • Chicken
  • Rat
  • Human
  • Bovine
  • Mammalian Cells
  • HEK293
  • E.coli
  • His
  • Non
  • Avi
  • Fc
  • DDK
  • Myc

    Involved Pathway

    PROKR2 involved in several pathways and played different roles in them. We selected most pathways PROKR2 participated on our site, such as Class A/1 (Rhodopsin-like receptors),G alpha (q) signalling events,GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with PROKR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    GPCR ligand binding CXCL13,GNB5B,DRD5,EDN1,NMBB,LTB4R,HRH3,GPR17,GPR31B,GPR39
    Gastrin-CREB signalling pathway via PKC and MAPK NMU,DGKQ,OXTRL,CCK,LTB4R,FFAR3,ABHD12,FPR-RS3,OPN4,NMB
    GPCR downstream signaling TAS2R16,CCL19A.2,CXCR6,MGLL,MLN,CCK,TAC1,ABHD6B,CNR2,GHRH
    G alpha (q) signalling events CASR,FFAR3,RGS21,NTS,TRPC7,LPAR2B,FPR-RS3,RGS19,PMCH,EDNRA
    GPCRs, Other VMN1R40,SETD6,ADORA3,CELSR1,CELSR2,LGR6,OR10A5,GPR77,VMN1R45,MRGPRH
    Class A/1 (Rhodopsin-like receptors) ADORA2A,SAA1,ADORA3,GPR17,CHRM2,APLN,OXER1,OPN4A,GPR55A,LPAR5A
    Signal Transduction RBP1,BCO2L,GPR37B,NPSR1,NOG,PTPRK,OPN4B,DZIP1,EVC,SPOPL
    Peptide ligand-binding receptors CXCR7B,CXCL11.8,CX3CR1,CCL19A.2,NMS,TAC2,GPR37L1,GPR37B,HCRT,ACKR4

    Protein Function

    PROKR2 has several biochemical functions, for example, G-protein coupled receptor activity,neuropeptide Y receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PROKR2 itself. We selected most functions PROKR2 had, and list some proteins which have the same functions with PROKR2. You can find most of the proteins on our site.

    Function Related Protein
    neuropeptide Y receptor activity PRLHR2B,NPY5R,NPY8AR,PROKR1,NPY2R,PRLHR2A,PRLHR,QRFPR,NPY8BR,NPY1R
    G-protein coupled receptor activity OLFR5,VMN1R49,NPFFR1,FZD9B,GPRC5B,CALCRLA,TAS2R123,CCR10,CXCR7B,OLFR149

    Interacting Protein

    PROKR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PROKR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PROKR2.

    Resources

    Research Area

    References

    • Brouillet, S; Hoffmann, P; et al. Molecular Characterization of EG-VEGF-mediated Angiogenesis: Differential Effects on Microvascular and Macrovascular Endothelial Cells. MOLECULAR BIOLOGY OF THE CELL 21:2832-2843(2010).
    • Garcia, S; Forteza, J; et al. Matrix metalloproteinase-8 deficiency increases joint inflammation and bone erosion in the K/BxN serum-transfer arthritis model. ARTHRITIS RESEARCH & THERAPY 12:-(2010).

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