Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

PRPF8

  • Official Full Name

    pre-mRNA processing factor 8

  • Overview

    Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this gene is a component of both U2- and U12-dependent spliceosomes, and found to be essential for the catalytic step II in pre-mRNA splicing process. It contains several WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp8 protein. This gene is a candidate gene for autosomal dominant retinitis pigmentosa. [provided by RefSeq, Jul 2008]
  • Synonyms

    PRPF8; pre-mRNA processing factor 8; PRP8; RP13; HPRP8; PRPC8; SNRNP220; pre-mRNA-processing-splicing factor 8; p220; PRP8 homolog; splicing factor Prp8; apoptosis-regulated protein 1; apoptosis-regulated protein 2; 220 kDa U5 snRNP-specific protein; precursor mRNA processing protein; PRP8 pre-mRNA processing factor 8 homolog; U5 snRNP-specific protein (220 kD), ortholog of S. cerevisiae Prp8p;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PRPF8-1979H Recombinant Human PRPF8, GST-tagged E.coli GST C-term-300aa
Zebrafish PRPF8-11211Z Recombinant Zebrafish PRPF8 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

PRPF8 involved in several pathways and played different roles in them. We selected most pathways PRPF8 participated on our site, such as Gene Expression, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRPF8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Gene ExpressionFKBP6;MAPKAPK2B;EEF1A2;ZNF543;ZNF34;ZNF302;ZIK1;RRP8;ZNF729
Processing of Capped Intron-Containing Pre-mRNANXF1;PRPF8;SF3B4;SLBP;SRSF11;HNRNPL2;ZMAT5;DNAJC8;CLP1
SpliceosomeXAB2;PRPF40B;SRSF2B;WBP11;LSM8;PRPF4;HSPA1A;SR140;SF3B6
mRNA SplicingPDCD7;SNRNP25;DNAJC8;HNRNPA0B;HNRNPUL1;SF3B2;SUGP1;HNRNPH2;SF3A3
mRNA Splicing - Major PathwayCCAR1;HNRPL;PTBP1A;HNRNPA0B;HNRNPH1L;PRPF8;HNRNPL2;HNRNPUL1;HNRNPA0A
mRNA Splicing - Minor PathwayTXNL4A;PRPF8;SNRNP35;SNRNP48;PDCD7;RNPC3;ZMAT5;YBX1;ZCRB1
mRNA processingMCTS2;EIF4E3;SRSF10;HNRNPH2;BICC1;LOC100862398;SF3A3;PTBP1A;Akap17b

PRPF8 has several biochemical functions, for example, K63-linked polyubiquitin binding, U1 snRNA binding, U2 snRNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRPF8 itself. We selected most functions PRPF8 had, and list some proteins which have the same functions with PRPF8. You can find most of the proteins on our site.

Function Related Protein
K63-linked polyubiquitin bindingIKBKG;TAB2;ZRANB1B;ATRIP;SPRTN;OTUD7B;PRPF8;RNF168;RNF169
U1 snRNA bindingISG20;SNRPA;PRPF8;SNRNP70
U2 snRNA bindingISG20;PRPF8;TROVE2;SNRPA1
U5 snRNA binding
U6 snRNA bindingLSM2;LSM8;PRPF4;EIF5A;RBM22;LSM4;LSM7;DDX39B;PRPF8
poly(A) RNA bindingSUGP1;DHX9;C14orf93;CAST;ALDH6A1;RPUSD4;DUT;MYO18A;CCT4
pre-mRNA intronic bindingSOX9;RBM4;PRPF8;HNRNPA2B1;RNPC3;RBM41;EP300
protein bindingHTR3E;FAM113B;FERD3L;PBX1;POP4;CHN2;HLCS;CD1B;TBC1D9B
second spliceosomal transesterification activitySLU7;PRPF8

PRPF8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRPF8 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRPF8.

SNRNP40; PRPF4; Snw1; SNW1; EFTUD2; BCAS2; SLU7; SF3B2; PCBP1

  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (0)

Write a review

Ask a Question for All PRPF8 Products

Required fields are marked with *

My Review for All PRPF8 Products

Required fields are marked with *

logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /

Stay Updated on the Latest Bioscience Trends