PRPF8
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Official Full Name
pre-mRNA processing factor 8 -
Overview
Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this gene is a component of both U2- and U12-dependent spliceosomes, and found to be essential for the catalytic step II in pre-mRNA splicing process. It contains several WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp8 protein. This gene is a candidate gene for autosomal dominant retinitis pigmentosa. [provided by RefSeq, Jul 2008] -
Synonyms
PRPF8;pre-mRNA processing factor 8;PRP8;RP13;HPRP8;PRPC8;SNRNP220;pre-mRNA-processing-splicing factor 8;p220;PRP8 homolog;splicing factor Prp8;apoptosis-regulated protein 1;apoptosis-regulated protein 2;220 kDa U5 snRNP-specific protein;precursor mRNA processing protein;PRP8 pre-mRNA processing factor 8 homolog;U5 snRNP-specific protein (220 kD), ortholog of S. cerevisiae Prp8p
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PRPF8-1979H | Recombinant Human PRPF8, GST-tagged | E.coli | Human | GST | C-term-300aa | |
| PRPF8-11211Z | Recombinant Zebrafish PRPF8 | Mammalian Cells | Zebrafish | His |
|
Involved Pathway
PRPF8 involved in several pathways and played different roles in them. We selected most pathways PRPF8 participated on our site, such as Gene Expression,Processing of Capped Intron-Containing Pre-mRNA,Spliceosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRPF8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Gene Expression | POLR3GLA,TAF1B,TET2,PPARAA,MTF2,ZNF839,ZNF547,SURF1,ZNF710,U2AF2 |
| Processing of Capped Intron-Containing Pre-mRNA | HNRNPL2,HNRNPL,HNRNPA0L,ZCRB1,HNRNPA0A,HNRNPH1L,SUGP1,RNPC3,METTL3,THOC4 |
| mRNA Splicing | SUGP1,HNRPL,HNRNPL,HNRNPH2,HNRNPA0B,SFRS3A,CD2BP2,SNRNP35,HNRNPA0,SF3A1 |
| mRNA Splicing - Minor Pathway | SF3B4,YBX1,SNRNP25,PDCD7,ZCRB1,ZMAT5,RNPC3,TXNL4A,SNRNP35,SF3B2 |
| mRNA Splicing - Major Pathway | HNRNPH1,YBX1,PTBP1,CCAR1,HNRNPA0,PCBP2,HNRNPH2,DNAJC8,TXNL4A,CD2BP2 |
| mRNA processing | RBM39A,CLK1,ZFML,PRMT2,TXNL4A,SNRPN,PRPF4BB,CELF1,HNRNPH2,LSMD1 |
| Spliceosome | PRPF31,CCDC12,HNRPKL,SRSF1B,XAB2,SRSF4,SF3A2,SF3B4,PRPF40B,PRP19 |
Protein Function
PRPF8 has several biochemical functions, for example, K63-linked polyubiquitin binding,U1 snRNA binding,U2 snRNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRPF8 itself. We selected most functions PRPF8 had, and list some proteins which have the same functions with PRPF8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | PLUNC,HMGB3,ZBTB4,PID1,MDM4,CLASP1,LIN37,GLYCTK,TRIM39,CDC7 |
| U2 snRNA binding | SNRPA1,TROVE2,ISG20 |
| U6 snRNA binding | LSM8,LSM7,LSM4,LSM2,EIF5A,SART3,RBM22,DDX39B,PRPF4 |
| U1 snRNA binding | SNRNP70,SNRPA,ISG20 |
| pre-mRNA intronic binding | RNPC3,HNRNPA2B1,EP300,RBM41,RBM4,SOX9 |
| K63-linked polyubiquitin binding | TAB2,RNF169,OTUD7B,ZRANB3,SPRTN,TNFAIP3,SQSTM1,RNF168,ZRANB1B,IKBKG |
| poly(A) RNA binding | AGO2,ZFP36L1,TRIP6,AHNAK,ELAC2,UTP15,SERBP1,SRSF12,HNRPLL,RPL17 |
| second spliceosomal transesterification activity | SLU7 |
Interacting Protein
PRPF8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRPF8 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRPF8.
SNRNP40;PRPF4;Snw1;SNW1;EFTUD2;BCAS2;SLU7;SF3B2;PCBP1
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