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PTGIS

  • Official Full Name

    prostaglandin I2 (prostacyclin) synthase

  • Overview

    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are;monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and;other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence;similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of;prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An;imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial;infarction, stroke, and atherosclerosis.
  • Synonyms

    PTGIS; prostaglandin I2 (prostacyclin) synthase; prostacyclin synthase; Cyp8; Pgis; Cyp8a1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PTGIS-830H Recombinant Human PTGIS protein, His-tagged E.coli His Met1~Pro500
Human PTGIS-30324TH Recombinant Human PTGIS Wheat Germ N/A 110 amino acids
Human PTGIS-30325TH Recombinant Human PTGIS Wheat Germ N/A 500 amino acids
Human PTGIS-2709HCL Recombinant Human PTGIS 293 Cell Lysate HEK293 N/A
Human PTGIS-2970H Recombinant Human PTGIS protein, His-tagged E.coli His 100-285 aa
Human PTGIS-412HF Recombinant Full Length Human PTGIS Protein In Vitro Cell Free System 500 amino acids
Human PTGIS-1793H-B Recombinant Human PTGIS Protein Pre-coupled Magnetic Beads HEK293
Human PTGIS-2002H Recombinant Human PTGIS Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PTGIS-1793H Recombinant Human PTGIS Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human PTGIS-717HFL Active Recombinant Full Length Human PTGIS Protein, C-Flag-tagged Mammalian cells Flag
Human PTGIS-6066H Recombinant Human PTGIS Protein (Thr24-Pro500), N-His tagged E.coli N-His Thr24-Pro500
Mouse Ptgis-5222M Recombinant Mouse Ptgis Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat PTGIS-4813R Recombinant Rat PTGIS Protein Mammalian Cell His
Rat PTGIS-4472R Recombinant Rat PTGIS Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PTGIS-4472R-B Recombinant Rat PTGIS Protein Pre-coupled Magnetic Beads HEK293
Mus musculus (Mouse) RFL22087MF Recombinant Full Length Mouse Prostacyclin Synthase(Ptgis) Protein, His-Tagged E.coli expression system His Full Length (1-501)
Zebrafish PTGIS-6229Z Recombinant Zebrafish PTGIS Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PTGIS Related Research Area

PTGIS involved in several pathways and played different roles in them. We selected most pathways PTGIS participated on our site, such as Arachidonic acid metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTGIS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Arachidonic acid metabolismCYP4F2;CBR3;PTGDS;CYP1A2;CYP4F3;CYP2U1;CYP2E1;CYP2P10;GGT5
Metabolic pathwaysCYP4A14;SUCLG1;ALDH3A2;HLCS;CES1;RDH10A;CKM;PIGQ;AK9

PTGIS has several biochemical functions, for example, heme binding, iron ion binding, monooxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PTGIS itself. We selected most functions PTGIS had, and list some proteins which have the same functions with PTGIS. You can find most of the proteins on our site.

Function Related Protein
heme bindingNOS3;CYP3A4;PTGIS;CYP2D26;CYB5B;FA2H;CYP2Y3;CYP2F1;CYP2AD2
iron ion bindingCYP1D1;FBXL5;P4HA3;NOS2A;CYP2K16;HBD;ALKBH8;AOX4;CYP2C50
monooxygenase activityCYP2X8;CYP2C39;CYP8B1;CYP2C70;COQ7;MICAL2;CYP39A1;FOXRED2;CYP2P7
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygenCYP27C1;CYP1C2;CYP2X8;CYP19A1A;CYP2P8;CYP1C1;CYP2AA3;CYP3C4;CYP39A1
prostaglandin-I synthase activity
protein bindingCALR;FIP1L1;BTBD1;FAM32A;SVIL;NVL;RASAL2;FAM46A;GTF2A2

PTGIS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTGIS here. Most of them are supplied by our site. Hope this information will be useful for your research of PTGIS.

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