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PURA

Official Full Name

purine-rich element binding protein A
Overview

This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia. [provided by RefSeq, Jul 2008]
Synonyms

PURA; purine-rich element binding protein A; PUR1; PURALPHA; PUR-ALPHA; transcriptional activator protein Pur-alpha; purine-rich single-stranded DNA-binding protein alpha;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Bacillus subtilis
Human
Mouse
Zebrafish

Source

E. coli or Yeast
E.coli
HEK293
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	PURA-31263TH	Recombinant Human PURA	Wheat Germ	N/A	51 amino acids	Inquiry
Human	PURA-2071H	Recombinant Human PURA, His-tagged	E.coli	His	1-322aa	$319 / 25ug
Human	PURA-31266TH	Recombinant Human PURA	Wheat Germ	N/A	110 amino acids	Inquiry
Human	PURA-30154H	Recombinant Human PURA protein, GST-tagged	E.coli	GST	Met1-Asp322	Inquiry
Human	PURA-6117H	Recombinant Human PURA Protein (Met1-Asp322), N-His tagged	E.coli	N-His	Met1-Asp322	Inquiry
Mouse	PURA-13722M	Recombinant Mouse PURA Protein	Mammalian Cell	His		Inquiry
Mouse	PURA-7301M	Recombinant Mouse PURA Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	PURA-7301M-B	Recombinant Mouse PURA Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Bacillus subtilis	PURA-0357B	Recombinant Bacillus subtilis PURA protein, His-tagged	E. coli or Yeast	His		Inquiry
Zebrafish	PURA-255Z	Recombinant Zebrafish PURA	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
PURA Related Articles

PURA involved in several pathways and played different roles in them. We selected most pathways PURA participated on our site, such as Diurnally regulated genes with circadian orthologs, which may be useful for your reference. Also, other proteins which involved in the same pathway with PURA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Diurnally regulated genes with circadian orthologs	TOB1;QKI;NCKAP1;NR1D2;ERC2;MYF6;PURA;CRY2;GFRA1

PURA has several biochemical functions, for example, SMAD binding, double-stranded telomeric DNA binding, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PURA itself. We selected most functions PURA had, and list some proteins which have the same functions with PURA. You can find most of the proteins on our site.

Function	Related Protein
SMAD binding	HMGA2;BMPR1B;ACVR1;SKOR1A;BMP2;SMURF2;SMAD2;SKILB;PURA
double-stranded telomeric DNA binding	TERF1;PURA;TERFA;TERF2
poly(A) RNA binding	EIF4E2;DHX35;CELF1;RTN4;RPSA;MRPS21;LARP2;RBMS1;RBM25
protein binding	DKK1B;NRIP2;NKG7;STXBP3;SPAG5;KMT2E;NEK1;FAM9B;RERG
purine-rich negative regulatory element binding	PURA;ELK3
single-stranded DNA binding	HNRNPK;TSN;HNRPDL;OBFC2B;DMC1;HMGB1;MCM10;RAD51L1;SSBP1
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	ZFHX3;PURA;MEIS1;HNF1B;PROX1;HIF1A;GATA5;SOX10;SOX7
transcription factor binding	STAT3;MLXIPL;FLNA;SUMO1;IRF4;TP53;KCNA3;LCOR;IGHMBP2
translation repressor activity, nucleic acid binding	PURA;CPEB1;CPEB4;CPEB2;CELF4;CELF1;CPEB3;CPEB1B;PPP1R2P9

PURA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PURA here. Most of them are supplied by our site. Hope this information will be useful for your research of PURA.

lt_sv40; lt_povjc; RB1; rb_cerae_protein; CNBP; EIF2AK2; GABARAPL2; SNW1; q8te30_human; ESR2

Li, J; Mo, ZL; et al. Generation and evaluation of virulence attenuated mutants of Edwardsiella tarda as vaccine candidates to combat edwardsiellosis in flounder (Paralichthys olivaceus). FISH & SHELLFISH IMMUNOLOGY 43:175-180(2015).

Kobayashi, Y; Suzuki, K; et al. C9orf10 protein, a novel protein component of Pur alpha-containing mRNA-protein particles (Pur alpha-mRNPs): Characterization of developmental and regional expressions in the mouse brain. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 56:723-731(2008).