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PFAS

  • Official Full Name

    phosphoribosylformylglycinamidine synthase

  • Overview

    Purines are necessary for many cellular processes, including DNA replication, transcription, and energy metabolism. Ten enzymatic steps are required to synthesize inosine monophosphate (IMP) in the de novo pathway of purine biosynthesis. The enzyme encoded by this gene catalyzes the fourth step of IMP biosynthesis.
  • Synonyms

    PFAS; phosphoribosylformylglycinamidine synthase; FGAR amidotransferase; FGARAT; KIAA0361; PURL; FGAM synthase; formylglycinamide ribotide synthetase; formylglycinamide ribotide amidotransferase; FGAMS;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • His
  • His (Fc)
  • Avi
  • His|SUMO|Myc
  • Myc
  • DDK
  • Myc|DDK
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PFAS-576H Recombinant Human PFAS Mammalian Cell His
Human PFAS-5088H Recombinant Human PFAS Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PFAS-2335H Recombinant Human PFAS Protein (1064-1302 aa), His-SUMO-Myc-tagged E.coli His/SUMO/Myc 1064-1302 aa
Human PFAS-1651H Recombinant Human PFAS Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human PFAS-919H Recombinant Human PFAS Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human PFAS-2579H Recombinant Human PFAS Protein, His-tagged E.coli N-His Arg1064-Val1302
Human PFAS-1651H-B Recombinant Human PFAS Protein Pre-coupled Magnetic Beads HEK293
Human PFAS-27HFL Recombinant Full Length Human PFAS Protein, C-Flag-tagged Mammalian cells Flag
Mouse Pfas-4805M Recombinant Mouse Pfas Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Pfas-1934M Recombinant Mouse Pfas Protein, His-tagged E.coli N-His Arg1063-Val1301
Zebrafish PFAS-4224Z Recombinant Zebrafish PFAS Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PFAS Related Articles

PFAS involved in several pathways and played different roles in them. We selected most pathways PFAS participated on our site, such as Purine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PFAS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Purine metabolismPDE3A;NUDT2;AK4;Adcy4;POLR2EB;NT5C2B;POLE3;AK2;PDE8B
Metabolic pathwaysCHPT1;CYCSB;GNSB;DEGS1;PIGO;PLA2G1B;UCK1;PLD2;PCYT2

PFAS has several biochemical functions, for example, ATP binding, metal ion binding, phosphoribosylformylglycinamidine synthase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PFAS itself. We selected most functions PFAS had, and list some proteins which have the same functions with PFAS. You can find most of the proteins on our site.

Function Related Protein
ATP bindingGRK7B;MERTK;PANK2;KCNJ10;GM711;ATP1A1A.4;CCC2;KALRN;KCNJ1
metal ion bindingZNF444;ZNF710;FGD;PFKMA;LMAN1;PAPD7;NUDT17;ITGB1;CYP2K17
phosphoribosylformylglycinamidine synthase activity

PFAS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PFAS here. Most of them are supplied by our site. Hope this information will be useful for your research of PFAS.

Webster, GM; Venners, SA; et al. Associations between Perfluoroalkyl acids (PFASs) and maternal thyroid hormones in early pregnancy: A population-based cohort study. ENVIRONMENTAL RESEARCH 133:338-347(2014).
Granum, B; Haug, LS; et al. Pre-natal exposure to perfluoroalkyl substances may be associated with altered vaccine antibody levels and immune-related health outcomes in early childhood. JOURNAL OF IMMUNOTOXICOLOGY 10:373-379(2013).
  • Q&As
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