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Official Full Name poliovirus receptor-related 4
Background This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.
Synonyms PVRL4; poliovirus receptor-related 4; poliovirus receptor-related protein 4; LNIR; nectin 4; PRR4; Ig superfamily receptor LNIR; Nectin-4; Processed poliovirus receptor-related protein 4; PVRL4_HUMAN; OTTHUMP00000029698; EDSS1
    • Species :
    • Cynomolgus
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Mammalian cells
    • Tag :
    • Fc
    • GST
    • His
    • His-Avi
    • mFc
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse PVRL4-12M Recombinant Mouse PVRL4(Gly31-Ile349) Protein, C-Fc-tagged HEK293 Fc
    Mouse PVRL4-13M Recombinant Mouse PVRL4(Gly31-Ile349) Protein, C-6*His-tagged HEK293 His
    Human PVRL4-199H Recombinant Human PVRL4(Gly32-Val351) Protein, C-mFc-tagged HEK293 mFc
    Human PVRL4-200H Recombinant Human PVRL4(Gly32-Val351) Protein, C-Fc-tagged HEK293 Fc
    Cynomolgus PVRL4-202C Recombinant Cynomolgus PVRL4(Gly32-Ser349) Protein, C-Fc-tagged HEK293 Fc
    Cynomolgus PVRL4-73C Recombinant Cynomolgus PVRL4(Gly32-Ser349) Protein, C-6*His-tagged HEK293 His
    Human PVRL4-201H Recombinant Human PVRL4 protein, His-Avi-tagged HEK293 His-Avi
    Human PVRL4-2081H Recombinant Human PVRL4, GST-tagged E.coli GST
    Human PVRL4-2657HCL Recombinant Human PVRL4 293 Cell Lysate HEK293 N/A
    Human PVRL4-776H Recombinant Human PVRL4 Protein, His-tagged Mammalian cells His
    Mouse PVRL4-13734M Recombinant Mouse PVRL4 Protein Mammalian Cell His
    Mouse Pvrl4-764M Recombinant Mouse Pvrl4 Protein, His-tagged Mammalian cells His

    PVRL4 involved in several pathways and played different roles in them. We selected most pathways PVRL4 participated on our site, such as Adherens junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with PVRL4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Adherens junction RAC1B; WASLA; Fert2; MLLT4; INSRA; AASS; WASLB; BAIAP2; RHOAB; CTNND1

    PVRL4 has several biochemical functions, for example, cell adhesion molecule binding, protein binding, protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PVRL4 itself. We selected most functions PVRL4 had, and list some proteins which have the same functions with PVRL4. You can find most of the proteins on our site.

    Function Related Protein
    cell adhesion molecule binding GRIN2A; LILRB2; ITGB7; NRXN3; NRXN1; PVRL2L; SMAGP; CD226; CRTAM; CAML
    protein binding CCDC146; GTF3C4; RDM1; DKK1; RAB1; MSN; ARHGAP26; VSIG4; DIAP1; MDM4
    protein homodimerization activity RRAGA; TPR; PON3; SNF8; SEPT12; TARS; ADRB2; TRIM9; TERF2; GRIK2
    receptor activity TNFRSF13B; RET; RAMP3; EPHB6; SELS; BTLA; PLXNA1; NLGN4X; VMN1R54; CD200R4
    receptor binding CRAT; UFD1L; HCST; TNFSF10; NXPH1; CAPRIN2; PLG; HFE2; ANXA1; FKBP1B
    virus receptor activity PVRL4; SERPINB4; CD86; PVRL1; ITGB3; IDE; MRC1; ITGB7; CCR5; ITGB5

    PVRL4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PVRL4 here. Most of them are supplied by our site. Hope this information will be useful for your research of PVRL4.

    PVRL1; H; TIGIT; PVRL2; MLLT4; Pick1

    Melia, MM; Earle, JP; et al. Use of SLAM and PVRL4 and Identification of Pro-HB-EGF as Cell Entry Receptors for Wild Type Phocine Distemper Virus. PLOS ONE 9:-(2014).
    Abdullah, H; Brankin, B; et al. Wild-type Measles Virus Infection Upregulates Poliovirus Receptor-Related 4 and Causes Apoptosis in Brain Endothelial Cells by Induction of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 72:681-696(2013).

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