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PYGO2

  • Official Full Name

    pygopus homolog 2 (Drosophila)

  • Overview

    Pygopus homolog 2 is a protein that in humans is encoded by the PYGO2 gene.
  • Synonyms

    PYGO2; pygopus homolog 2 (Drosophila); pygopus homolog 2; 1190004M21Rik; FLJ33226; Pygo2 protein; PYGO2_HUMAN; pygopus 2; OTTHUMP00000035488;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PYGO2-1451HCL Recombinant Human PYGO2 cell lysate N/A
Human PYGO2-1932H Recombinant Human PYGO2 protein, His & GST-tagged E.coli His/GST Leu171~Gly406 (Accession # Q9BRQ0)
Human PYGO2-6686H Recombinant Human PYGO2 Protein (Leu171-Gly406), N-His tagged E.coli N-His Leu171-Gly406
Zebrafish PYGO2-3396Z Recombinant Zebrafish PYGO2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

PYGO2 involved in several pathways and played different roles in them. We selected most pathways PYGO2 participated on our site, such as Deactivation of the beta-catenin transactivating complex, Formation of the beta-catenin:TCF transactivating complex, Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with PYGO2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Deactivation of the beta-catenin transactivating complexSRY;SOX4B;TLE3;SOX6;PYGO2;SOX4A;SOX7;ASH2L;BCL9
Formation of the beta-catenin:TCF transactivating complexTLE3B;TLE1;LEO1;CDC73;TLE3;BCL9L;SMARCA4;PYGO2;TLE4
Signal TransductionRTKN;TNKS2;EMR2;CALML4;GPR77;IFT122;MDKA;FAM13B;TRH
Signaling by WntKREMEN2;KLHL12;HECW1;RSPO4;SOX4B;SOX6;ZNRF3;CSNK1G2;PRICKLE1B
TCF dependent signaling in response to WNTRYK;SOX9B;CCDC88C;C;TNKS;SOX4A;LGR6;SOX32;SOX9A

PYGO2 has several biochemical functions, for example, chromatin binding, histone acetyltransferase regulator activity, histone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PYGO2 itself. We selected most functions PYGO2 had, and list some proteins which have the same functions with PYGO2. You can find most of the proteins on our site.

Function Related Protein
chromatin bindingHMGB3A;NKX6;ZFP354B;PPARG;REL;TOX4;TP53;MTA3;TLE1
histone acetyltransferase regulator activityPYGO2;EID1
histone bindingPIH1D1;HIST1H4N;L3MBTL2;BAZ2A;UHRF2;HINFP;BRDT;HIST1H3D;CHD8
protein bindingMOB3C;IL1RAPL1;HUWE1;CX3CL1;FNTA;RPS6KA1;GCA;PSMA1;TYROBP
zinc ion bindingMT1;BRF1;KDM2A;ZDHHC18A;S100A8;PGR;CAR3;MLL1;RBM4.2

PYGO2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PYGO2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PYGO2.

BCL9; JRK; Bcl9l; CDC73

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